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Showing 1 to 20 of 22 for “"Losartan"”.

  1. The Angiotensin Receptor (AT₁) Inhibitor, Losartan, Slows Post-Natal Thickening of the Left Ventricle

    Javadi, FaribaSouthwest Texas State University1994

    … RAS in left ventricular development by giving losartan, an angiotensin IT (AII) AT; receptor antagonist to pregnant rats. Hearts were removed from neonates, fixed and cryosections cut with litter-mates being similarly processed at 24 hour intervals. Micrographs were obtained and morphometric …

    texas-state Repository record

  2. Einfluß von Losartan auf das L-Arginin/NO-System im ischämischen akuten Nierenversagen der Ratte

    Erler, JohannesUniversität Würzburg

    Die vorliegende Arbeit untersucht den Einfluß von Losartan, L-Arginin und L-NMMA auf das akute ischämische Nierenversagen der Ratte. Der zentrale Mechanismus ist das L-Arginin/NO-System, in dem durch die NO-Synthetase aus L-Arginin NO abgespalten wird. NO ist über seine vasodilatatierende Wirkung …

    wurz-thes Repository record

  3. Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model

    Lauren Patricia ForesmanThe University of Texas Medical Branch2008

    … damage in Type II lung epithelial cells. Losartan is an AngII, AT1A specific receptor blocking. Using an ovine model of acute respiratory distress, we hypothesized that blocking AngII receptors with losartan would improve the clinical conditions seen in response to the injury. Chronically …

    utmb Repository record

  4. Effects of the Angiotensin II Antagonist, Losartan, on Circulo-Respiratory Responses to Submaximal Exercise in Hypertensive Women

    Craft, Laura LeeVirginia Tech1997

    The effects of the antihypertensive agent Losartan (Lo), on acute exercise performance was assessed in six sedentary, hypertensive women. The purpose, benefits and potential risks of the study were explained to each subject and their informed consent received. In a double blinded crossover design …

    vt Repository record

  5. Pharmacological characterization of losartan as a CCR2 antagonist and pre-clinical and pharmacodynamic assessment as a potential anti-metastatic therapy

    Regan, Daniel P., author, Dow, Steven, advisor, Schenkel, Alan, committee member, Thamm, Douglas, committee member, Slansky, Jill, committee member, Basaraba, Randall, committee memberColorado State University. Libraries2017

    To view the abstract, please see the full text of the document.

    colostate Repository record

  6. Effets centraux d'antagonistes non-peptidiques sélectifs pour les récepteurs AT1 ou AT2 de l'angiotensine II chez le rat hypertendu spontanément

    Paré, Marie-ChristineUniversité de Sherbrooke1992

    … sélectifs pour les récepteurs AT, Losartan et L158809, induisent une réduction significative (jusqu'à 40 mmHg) de la PA chez le SHR. Cet effet, qui dure plusieurs jours, ne se développe que 18 heures après l'injection icv, laissant supposer qu'un métabolite est formé. Pourtant, …

    sherbrooke Repository record

  7. RETROSPECTIVE DESCRIPTIVE STUDY ON POST-MARKET MEDICINE QUALITY-RELATED COMPLAINTS AND THE APPLICATION OF FIELD-BASED DETECTION OF POORQUALITY MEDICINES USING NEAR-INFRARED AND RAMAN SPECTROSCOPIC SCREENING METHODS

    Toroitich, Anthony MartinDe Montfort University2025

    … essential tablets, including metronidazole, losartan, and a fixed-dose combination antiretroviral tenofovir/lamivudine/dolutegravir. Laboratory studies assessed the performance of handheld Near-Infrared (NIR) and Raman spectrometers on identical medicine samples. A chemometric workflow …

    de-montfort Repository record

  8. Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models

    Peters, Andrew M, <p>http://www.orcid.org/0000-0002-0070-7386</p>2018

    … worsened the aortic phenotype. Treatment with losartan, an ARB, attenuated the aortic dilation, but captopril, an ACEi, did not decrease aortic growth and worsened the disease. Transverse aortic constriction (TAC) was used to study the ascending aorta and aortic root in response to increased …

    uthsc Repository record

  9. Modulating tissue mechanics to increase oxygen delivery to tumors

    Martin, John Daniel, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2015

    … treatment outcomes. First, we demonstrated that losartan, an FDA-approved therapy indicated for hypertension, decreases the activation of fibroblasts and the production and maintenance of collagen and hyaluronan. As a result, losartan decompressed vessels, restored perfusion, decreased hypoxia, …

    mit Repository record

  10. FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS

    Flynn, Colleen A.University of Kansas2011

    … drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome P450 (CYP) activities, a significant decrease in fexofenadine AUC was observed without a change in elimination. Based on this observation, I hypothesized a fexofenadine-probe drug interaction was occurring during …

    ku Repository record

  11. Angiotensin II Modulation of NMDA Receptor Function: Characterization of Mechanisms Attenuating Excitotoxicity in Neurons

    Schelman, William RussellUniversity of Illinois at Urbana-Champaign2015

    … PD 123319, but was not significantly altered by losartan. Taken together, these results suggest that the decrease in Bcl-2 expression induced by NMDA is attenuated by AT2 activation. (Abstract shortened by UMI.).

    uiuc Repository record

  12. Einfluss der beiden endogenen Peptide Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Kardiomyozyten von menschlichem Vorhof- und Ventrikelmyokard

    Rummer, Caroline

    … II, die sich durch den AT1-Rezeptorenblocker Losartan vollständig blockieren ließ. Auch Endothelin-1 bewirkte an Vorhofkardiomyozyten konzentrationsabhängig eine positive Inotropie, die sich durch den spezifischen ETA-Rezeptorenblocker BQ 123 verhindern ließ. <br>Dagegen konnte an Myozyten aus …

    freiburg-diss Repository record

  13. Einfluss des Renin-Angiotensin-Systems auf die menschliche Erythropoetinproduktion unter normoxischen Bedingungen und nach Stimulation durch Fenoterol

    Schenck, Tim2012

    … aus Fenoterol in gleicher Dosierung plus 50mg Losartan einmalig oral als selektivem AT-II1-Rezeptor-Antagonisten (KOMBINATION) in einer offenen placebokontrollierten und randomisierten Studie.Ergebnisse: Wir konnten zeigen, dass 6 Stunden nach der Medikamentengabe die Erythropoetin-Produktion …

    goettingen Repository record

  14. Arterial Wall Hypertrophy and PDGF-A Expression in One-Kidney, One-Clip Hypertension and Angiotensin II Infusion Are Mediated By Elevated Arterial Pressure

    Parker, Sheri Blair2019

    … one-clip (1K1C) hypertension or sham operation. Losartan, an AT1 receptor antagonist, was administered chronically to half of each surgical group beginning one day before the operation and continued until the end of the study. In a second experiment, rats were implanted with osmopumps delivering …

    odu Repository record

  15. Einfluß von Cyclsoporin A auf intrazelluläre Regulationsmechanismen des apikalen Na-H-Austauschers der proximalen Tubuluszelle : ein in vitro Modell

    Hartmann, Kathrin

    … des NHE-3 konnten nicht festgestellt werden. Losartan zeigte ebenfalls keinen Einfluß auf die Cyclosporin A-assozierte NHE-3-Aktivität. Eine Wirkung von Cyclosporin A auf Angiotensin II-vermittelte Effekte am proximalen Tubulus scheint daher unwahrscheinlich. <br>Ebenso konnte ein Einfluß von …

    freiburg-diss Repository record

  16. The role played by angiotensin (1-7) in the regulation of renal haemodynamics and excretory function in anesthetized rats

    O'Neill, JulieUniversity College Cork2013

    … in the presence of the AT 1 receptor antagonist (Losartan) in the presence of the, 'Mas' receptor antagonist (A-779). These data suggest that both AT1 and 'Mas' receptors need to be functional in order to fully mediate the renal responses to intra-renal Ang (1-7) infusion. Importantly, further …

    cork Repository record

  17. Determining stromal evolution in response to immune checkpoint inhibition

    Moody, WilliamUniversity of Cambridge2022

    … to ICI response. Combination of αPD-1 with losartan, a collagen synthesis inhibitor, showed a synergistic effect, increasing T cell infiltration and decreasing tumour growth. Together, these results show that the non-immune stroma plays an important role in determining ICI therapeutic …

    cambridge Repository record

  18. Ocorrência e distribuição de fármacos, cafeína e bisfenol-a em alguns corpos hídricos no Estado do Rio de Janeiro

    Gonçalves, Eline SimõesNiterói2012

    … torasemida, glibenclamida, irbesartan, losartan, valsartan, warfarina, tiabendazol, xilazina, sulfametoxazol, trimetoprim), cafeína e bisfenol-a, empregando a técnica analítica de extração em fase sólida, cromatografia a líquido de alta eficiência e espectrometria de massa tandem. Os …

    brazil-uff Repository record

  19. Proliferationsverhalten kultivierter Mesangialzellen und glatter Gefäßmuskelzellen nach Stimulation mit Angiotensin II und atherogenen Lipoproteinen : Rezeptorbeteiligung

    Wagner, MartinUniversität Würzburg

    … Die spezifische Hemmung des AT1-Rezeptors mit Losartan bewirkte ebenfalls keine signifikanten Änderungen. Auch die Inkubation der Zellen mit Agenzien, die die AT1-Rezeptordichte erhöhen sollten, erbrachte im Western Blot keine Veränderungen. Im Vergleich unterschiedlich alter Zellpopulationen …

    wurz-thes Repository record

  20. Preeclampsia, Autoimmunity and The At1 Receptor

    Irani, Roxanna A2010

    … of AT1-AA with an anti-TNF-alpha antibody, losartan (an AT1 receptor blocker) or an antibody-neutralizing peptide, 7-aa. In order to test the pathophysiologic relationship between AT1-AA and TNF-alpha in vivo, the established adoptive transfer mouse model was employed. Co-injection of AT1-AA …

    uthsc Repository record

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