Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Long-term survivors"”.
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Anti-Insect Defensive Behaviors of Equines after West Nile Virus Infection
… and neurological reflex testing suggest that long-term survivors of WNV do not show a change in the frequency or types of behaviors used compared to uninfected horses, supporting the idea that lasting deficits from WNV infection usually resolve within a year. On the other hand, microhabitat …
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Cure Rate Model with Spline Estimated Components
… analysis of medical studies, there are often long term survivors who can be considered as permanently cured. The goals in these studies are to estimate the cure probability of the whole population and the hazard rate of the noncured subpopulation. The existing methods for cure rate models have …
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Cure Rate Models with Nonparametric Form of Covariate Effects
… Such data can be found in survival studies with long term survivors. Consequently, the population consists of the susceptible and non-susceptible sub-populations with the latter termed as "cured". The modeling of both the cure probability and the hazard function of the susceptible sub-population …
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Long-Term Neuropsychological Effects in Survivors of Pediatric Low-Grade Gliomas
… have improved resulting in a population of long-term survivors, albeit with limited knowledge of their neurocognitive function, quality of life, and adaptive function. Methods: Patients treated at The Childrens Hospital at Westmead, Sydney, Australia during childhood (ages 6-18), and a …
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Infrastructure Development For Personalized Risk Prediction to Reduce Cardiovascular Disease In Childhood Cancer Survivors
<p>Although childhood cancer survivors have lengthy life expectancies, they run the risk of experiencing long-term health issues as a result of their treatment. The most frequent non-cancerous cause of morbidity and mortality for these survivors is cardiac disease. Radiation therapy (RT) has been …
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Comparison of quality of life and health behaviors between melanoma survivors and controls
… captures the specific issues faced by melanoma survivors. Studies of long-term melanoma survivors are lacking, and the survivorship research to date has been limited by the inability to make comparisons with a population control group. The goal of this dissertation was to document the long-term …
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Second cancers following treatment for retinoblastoma
… to these questions, a large cohort of 1852 long-term survivors of retinoblastoma was assembled to evaluate systematically the risk of second cancers. The work described in this thesis, which comprises six major studies, that have used this cohort to identify a higher risk than previously …
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Improving Mixture Cure Modelling of Multiple Molecular Factors in Cancer Prognosis
… data in which the study sample includes long-term survivors, the mixture cure (MC) model is more appropriate than a conventional proportional hazards model. In samples with few events, standard maximum likelihood (ML) estimates can be biased and Wald-type confidence intervals may not be …
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Extending Sample Size Calculation for the Cox Proportional Hazards Model
… proportion of patients being cured (or long-term survivors), such as trials for the non-Hodgkin's lymphoma disease. The popularly used sample size formula derived under the Cox proportional hazards (PH) model may not be proper to design a survival trial with a cure fraction, since the PH …
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Pulse electric field effect on cervical cancer cell: a plant based anti-cancer study
… treatment have resulted in high number of long- term survivors who are left to deal with the aftereffect of their therapy. Drug delivery is a challenging aspect in medical community as the plasma membrane is non-permeable to external molecules. From this context, a study was proposed to use …
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An Interpretive Phenomenological Exploration of Quality of Life Issues in Autologous Blood Cell Transplant Recipients
… solid tumours. The number of patients who are long term survivors and free of disease following this treatment is growing rapidly. To enable nurses and health care workers to provide optimal supportive care for these patients, an understanding of how the transplant has affected their quality of …
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Studies of Prognosis and Nutritional Intervention in Liver Cirrhosis and Liver Transplantation
… and whether PEM returns to normal in the long term, following successful OLT. To assist with these aims, accurate assessment of PEM is required. The body composition laboratory (BCL) offers state of the art methods to assess nutritional status. Dual-energy x-ray absorptiometry (DXA) and in …
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Characterisation of the mechanisms of tumour-induced dysfunction of clonal T cell expansions in multiple myeloma
… required to remove residual disease and maintain long term survival. Expanded clones of cytotoxic T cells have been detected in myeloma and their presence is associated with improved survival, suggesting a role in anti-tumour immunity. However, these cells are dysfunctional as they do not …
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… H3K27me3 level in patients displaying short-term survival (< 2 years after diagnosis) and associated with an increased tumour resistance to chemotherapy, compared to Long-Term Survivors (LTS) (> 10 years after diagnosis), with an improved sensitivity to the platinum-based treatment. By …
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Acute Pain Prediction in Oral Cavity and Oropharyngeal Cancer Patients Receiving Radiation Therapy
… acute iatrogenic pain. Moreover, about 45% of long-term survivors report chronic pain, with more than 10% exhibiting severe chronic pain. Pain control is challenging due to the multifactorial clinical, molecular, and cellular etiology of cancer/therapy pain, as well as variation in pain …
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The development and course of heart failure after a myocardial infarction
… may be declining, this may be offset by greater longevity in the general population. The incidence of acute coronary syndromes (ACS) is much higher. The incidence and outcome of both ACS and of MI will depend greatly on how data are collected.The cumulative incidence, persistence and resolution …
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Experiences of pregnancy with major fetal anomalies
… there is no universally agreed definition, the term fatal fetal anomaly (FFA) is widely used to describe a condition likely to lead to death of the fetus in utero or within 28 days of birth. Delivering a diagnosis of a FFA is usually unexpected and is an unwanted and traumatic event for parents. …