Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Long-term depression (LTD)"”.
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local stimulation approach in combination with intracellular recordings and …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… on synaptogenesis, synaptic pruning, and long-term depression (LTD) remain unclear. To address this gap, this study investigated synaptic weakening via LTD induction, spine development across postnatal stages via Golgi-Cox staining, and proteomic alterations in the hippocampus of Mdga2+/- …
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Effects of Reticular Activation on Long-Term Depression in Primary Visual Cortex of the Long-Evans Rat
Long-term depression (LTD) is a widely studied form of activity-dependent synaptic plasticity, typically induced by prolonged low-frequency stimulation (LFS). LFS is highly effective in eliciting LTD in vitro, but several studies have failed to induce LTD using LFS in vivo, for reasons that remain …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… conditioning (CFC; an animal model of fear). The long-term depression (LTD)-blocking peptide Tat-GluR2 was utilized to investigate whether the expression of cannabinoid-induced LTD (CB-LTD) is required for the cannabinoid impairment of acquisition and consolidation of contextual fear memory. HU210 …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
… correlates of such plasticity measurements, ie long-term potentiation (LTP) and long-term depression (LTD). Complete removal of NMDA receptors abolishes plasticity, while selective removal of NMDA receptors from distinct circuits in the visual system can reveal a more specific requirement and …
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Ethanol priming and its effects on consumption and accumbal plasticity
… N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the D1 MSNs of the NAc shell are seen following chronic intermittent ethanol (CIE) exposure and sustained operant responding. To our knowledge, however, LTD induction has not been extensively studied in volitional …
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Functional role of NMDA receptor subunit composition in metaplasticity
… activation, synapses are strengthened (long-term potentiation; LTP) and below this level, synapses are weakened (long-term depression; LTD). Previous work in visual cortex has suggested that the threshold for synaptic modifications is dependent on the recent history of visual experience, …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… and schizophrenia. We find that NMDAR-dependent long-term depression (LTD) and deprived-eye depression in layer 4 of V1 require metabotropic glutamate receptor 5 (mGluR5) signaling during postnatal development. Additionally, schizophrenia-associated protein neurogranin overexpression in V1 …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
In the cerebellar cortex, forms of both long-term depression (LTD) and long-term potentiation (LTP) can be observed at parallel fibre (PF) - Purkinje cell (PC) synapses. A presynaptic variant of cerebellar LTP can be evoked in PCs by raised frequency stimulation (RFS) of parallel fibre at 4-16Hz …
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TWO TYPES OF ROS ARE DIFFERENTIALLY INVOLVED IN SPINAL SYNAPTIC PLASTICITY AND MECHANICAL HYPERSENSITIVITY IN NEUROPATHIC PAIN
… synapses in the dorsal horn express two forms of long term changes in excitability––long term potentiation (LTP) and long term depression (LTD)––which contribute towards increased pain signaling to higher brain regions. Molecular mechanisms involved in the induction and maintenance of spinal LTP …
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
Synaptic plasticity (long-term potentiation, LTP and long-term depression, LTD) plays an important role in processes of learning and memory formation. In order to provide a link between these neurophysiological and cognitive processes the following experiments were performed using behavioral, …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
… it has been shown that insulin produces long term depression (LTD) in region CA1 of the juvenile and mature rat hippocampus. Using western blot analysis and field potential slice electrophysiology, I performed studies to further investigate the mechanisms underlying insulin-LTD. In …
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Induction and Maintenance of Synaptic Plasticity
Synaptic long-term modifications following neuronal activation are believed to be at the origin of learning and long-term memory. Recent experiments suggest that these long-term synaptic changes are all-or-none switch-like events between discrete states of a single synapse. The biochemical network …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… frequency 10 Hz stimulation protocol produces long-term potentiation (LTP) that is modulated by eCBs in both mice and rats; but surprisingly, the roles played by eCBs differ greatly between species. In rats, 10 Hz LTP requires CB1 receptor activation, as it is completely abolished by the CB1 …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… frequency 10 Hz stimulation protocol produces long-term potentiation (LTP) that is modulated by eCBs in both mice and rats; but surprisingly, the roles played by eCBs differ greatly between species. In rats, 10 Hz LTP requires CB1 receptor activation, as it is completely abolished by the CB1 …
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Generation and Analysis of Gene-Targeted Mouse Models for Oppenheim's Early-Onset Dyt1 Dystonia
… the cause of the elimination of corticostriatal long-term depression (LTD) also detected in KI mice. Further motor learning behavioral testing revealed a severe deficiency of motor skill adaptation in KI mice that may be correlated with the absence of LTD. KD mice that expressed close to 60% of …
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Age-dependent effects of chronic amphetamine on prelimbic-nucleus accumbens circuit function and goal-directed behavior
… the high frequency stimulation (HFS)-induced long-term depression (LTD) in the prelimbic cortex (PL) is likely to be a target influenced by repeated AMPH in an age-of-exposure dependent manner, which results in abnormalities in the reward circuit function and goal-directed behavior. Using a …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… responses rapidly weaken through homosynaptic long-term depression (LTD). As the period of deprivation progresses, the modification threshold determining the boundary between synaptic depression and synaptic potentiation becomes lower via a decrease in the ratio of NR2A to NR2B …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… cortex. We report that NMDA receptor-dependent long-term depression (LTD) is reduced specifically in layer IV of visual cortex in mGluR5 knockout mice, as well as in wild-type mice treated chronically with CTEP. However, LTD induction is normal in the presence of acute mGIuR5 antagonism in …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… modification of synapses, as in long term potentiation (LTP) or long term depression (LTD), is widely believed to be a crucial mechanism for learning and memory. Molecular perturbations in these processes may underlie certain neuropsychiatric conditions. This thesis examines the …
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