Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"Long-Term Depression"”.
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… responses rapidly weaken through homosynaptic long-term depression (LTD). As the period of deprivation progresses, the modification threshold determining the boundary between synaptic depression and synaptic potentiation becomes lower via a decrease in the ratio of NR2A to NR2B …
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Effect of chemically induced mGluR-dependent long-term depression on dendritic spine volume
… synapses that express any form of LTP and LTD (long-term potentiation and depression, respectively) are tagged in a protein synthesis-independent manner, the induction of LLTP/ L-LTD leads to protein synthesis, and all tagged synapses can use the resulting plasticity-related products to express …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… on synaptogenesis, synaptic pruning, and long-term depression (LTD) remain unclear. To address this gap, this study investigated synaptic weakening via LTD induction, spine development across postnatal stages via Golgi-Cox staining, and proteomic alterations in the hippocampus of Mdga2+/- …
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Effects of Reticular Activation on Long-Term Depression in Primary Visual Cortex of the Long-Evans Rat
Long-term depression (LTD) is a widely studied form of activity-dependent synaptic plasticity, typically induced by prolonged low-frequency stimulation (LFS). LFS is highly effective in eliciting LTD in vitro, but several studies have failed to induce LTD using LFS in vivo, for reasons that remain …
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… glutamate receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent LTD is enhanced and …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local stimulation approach in combination with intracellular recordings and …
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CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE
… water maze, electrophysiological recordings of long-term potentiation (LTP) and long-term depression (LTD) in anesthetized rats, and immunoblot analyses of learning- and memory-related signaling and AD-related molecules. Chronic psychosocial stress was induced using a rat intruder model. The …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… conditioning (CFC; an animal model of fear). The long-term depression (LTD)-blocking peptide Tat-GluR2 was utilized to investigate whether the expression of cannabinoid-induced LTD (CB-LTD) is required for the cannabinoid impairment of acquisition and consolidation of contextual fear memory. HU210 …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
… correlates of such plasticity measurements, ie long-term potentiation (LTP) and long-term depression (LTD). Complete removal of NMDA receptors abolishes plasticity, while selective removal of NMDA receptors from distinct circuits in the visual system can reveal a more specific requirement and …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… microscopy, and electrophysiologic tools, we determined that late Pten loss does not affect hippocampal development, neuronal or synaptic structure or basic synaptic transmission. However, it does cause deficits in both major forms of synaptic plasticity, long-term potentiation and long-term …
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Impaired and enhanced spatial representation of the PSD-95 knockout mouse
… dramatic enhancement of synaptic strengthening. Long Term Potentiation is enhanced at all frequencies of stimulation (1-100Hz), while Long Term Depression is absent in the mutants. This study explores CA1 pyramidal cell spatial representations in the PSD-95 mutant mice. Mutants are not …
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Ethanol priming and its effects on consumption and accumbal plasticity
… N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the D1 MSNs of the NAc shell are seen following chronic intermittent ethanol (CIE) exposure and sustained operant responding. To our knowledge, however, LTD induction has not been extensively studied in volitional …
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Functional role of NMDA receptor subunit composition in metaplasticity
… activation, synapses are strengthened (long-term potentiation; LTP) and below this level, synapses are weakened (long-term depression; LTD). Previous work in visual cortex has suggested that the threshold for synaptic modifications is dependent on the recent history of visual experience, …
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Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… changes can be disrupted or consolidated into a long-term memory. In this thesis we describe novel results that show that consolidation of the VOR can take place rapidly, within 1 hour after learning has stopped. Furthermore, we demonstrated that unlike learning, which has been shown to have …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… and schizophrenia. We find that NMDAR-dependent long-term depression (LTD) and deprived-eye depression in layer 4 of V1 require metabotropic glutamate receptor 5 (mGluR5) signaling during postnatal development. Additionally, schizophrenia-associated protein neurogranin overexpression in V1 …
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SEX DIFFERENCES IN THE ROLE OF PKMζ IN DRUG SELF-ADMINISTRATION AND PREFRONTAL CORTEX SYNAPTIC PLASTICITY
… The goal of these experiments was to determine the role of protein kinase M zeta (PKMζ), a protein involved in the trafficking of AMPA receptors (AMPARs), in drug taking behaviors and synaptic plasticity. PKMζ belongs to the protein kinase C family and is exclusively in the central …
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Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
… in modulating synaptic plasticity in the form of long-term potentiation and long-term depression. The mechanisms by which Panx1 contributes to synaptic physiology are largely unknown. Its high expression in many brain regions (including the hippocampus), postsynaptic localization, ability to …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
In the cerebellar cortex, forms of both long-term depression (LTD) and long-term potentiation (LTP) can be observed at parallel fibre (PF) - Purkinje cell (PC) synapses. A presynaptic variant of cerebellar LTP can be evoked in PCs by raised frequency stimulation (RFS) of parallel fibre at 4-16Hz …
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Long Term Plasticity Induced by Intracellular Tetanization in the Rat Auditory Cortex
… asked if intracellular tetanization can induce long-term plasticity in auditory cortex. We recorded evoked excitatory postsynaptic potentials (EPSPs) in layer 2/3 pyramidal cells in slices from rat auditory cortex. Two types of inputs were observed. Regular inputs (observed at 68 of 90 inputs, …
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TWO TYPES OF ROS ARE DIFFERENTIALLY INVOLVED IN SPINAL SYNAPTIC PLASTICITY AND MECHANICAL HYPERSENSITIVITY IN NEUROPATHIC PAIN
… synapses in the dorsal horn express two forms of long term changes in excitability––long term potentiation (LTP) and long term depression (LTD)––which contribute towards increased pain signaling to higher brain regions. Molecular mechanisms involved in the induction and maintenance of spinal LTP …
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