Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Long-Evans"”.
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Exploring the cardioprotective effect of synthetic wine in Long Evans rats
[No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, the delineation of the putative cardioprotective …
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Circadian disruption causes deficits in attention and response inhibition in adult Long-Evans rats
… serial reaction time task (5-CSRTT). Adult Long-Evans rats of both sexes were maintained on a 12h:12h light:dark cycle and tested under 3 conditions: 4 h into the dark phase with no exposure to ambient light at the time of testing (control), 4 h into the dark phase with exposure to ambient …
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Characterizing the Development of Reward Evaluation Across Adolescence in Female and Male Long-Evans Rats
… for reward across adolescence in female and male Long-Evans rats. In chapter 2, I used a free-access drinking task to compare how testing conditions (within- group or between-group) influenced intake of diluted sweetened condensed milk and found that previous test experience was necessary to …
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Effects of Reticular Activation on Long-Term Depression in Primary Visual Cortex of the Long-Evans Rat
Long-term depression (LTD) is a widely studied form of activity-dependent synaptic plasticity, typically induced by prolonged low-frequency stimulation (LFS). LFS is highly effective in eliciting LTD in vitro, but several studies have failed to induce LTD using LFS in vivo, for reasons that remain …
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EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS
… than the dorsal hippocampus (DHC). Adult female Long Evans rats underwent a 10-12 day CIE protocol, followed by 24-48 hours of withdrawal. At which point electrophysiological or behavioral testing was conducted. Surprisingly, CIE led to an overall decrease in hippocampal excitability, and this …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have gained popularity as a tool to investigate the neural substrates of behaviour in rodents. When used with spontaneous behavioural tests of memory in rodents, DREADDs allow for a unique opportunity to advance our understanding …
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Devaluation of Sucrose Caused by Social Instability Stress in Adolescent Male Long-Evans Rats in the Presence of an Unfamiliar Peer
… stress-induced devaluation of sucrose was not long-lasting as it was not found in adolescent males tested after a delay. Thus, Social Instability stress produces short-lasting behavioural changes in reward processing only in adolescent male rats.
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Behavioural, Pharmacological, and Immunohistochemical Investigation of 50 kHz USVs as an Expression of Positive Emotional Arousal in the Long Evans Rat
The emission of ultrasonic vocalizations (USVs) in Rattus norvegicus is thought to effectively represent an underlying emotional state within the organism manifested at the behavioural level. The main goal of my thesis was to characterize, at multiple levels of analysis, the 50 kHz USVs of the …
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Soziale Belastung während der Trächtigkeit bei Long-Evans Laborratten (Rattus norvegicus) und ihre Effekte auf die Reproduktion sowie die Physiologie, das Verhalten und die Reproduktion ihrer Nachkommen
… während der Trächtigkeit (maternaler Stress) bei Long-Evans Laborratten auf die Reproduktion der Parentalgeneration (F0-Weibchen) selbst, sowie auf die Reproduktion, das Verhalten und die Physiologie ihrer pränatal gestressten Nachkommen (F1-Generation) auswirkt (pränataler Stress). Hierbei galt …
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Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
… within a 3.5 hour window from stroke onset. A long-term delayed ischemic stroke treatment proposed by this study was a combination of the pharmaceuticals Fluoxetine (SSRI), Simvastatin (statin), and ascorbic acid (Vitamin C). 51 adult rat subjects (10-12 months of age; 44 Sprague Dawley, 7 Long …
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The differential effects of stressors on aversive, novel and appetitive stimuli in rats
… that Sprague-Dawley rats are more "anxious" than Long-Evans rats. The more reactive Sprague-Dawley rats exhibited a behavioral profile similar to that seen in stressed Long-Evans rats in the earlier studies. These studies support the hypothesis that exposure to stressors preferentially enhance the …
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Distribution of sleep structure is maintained, but adjusted in an acute circadian shift: a study by continuous long-term local field potential recording
… prefrontal cortex of freely behaving adult male Long Evans rats. The current analysis indicates that daily quantities of sleep are strongly maintained in an acute circadian shift. Furthermore, hourly sleep distributions are largely maintained during the shift. Contrastingly, an acute circadian …
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The crossed mesostriatal pathway and circling behaviour in rats
… the crossed projection was investigated in male Long-Evans rats using retrograde HRP tract tracing from deposition sites in the striatum.
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Investigating the Role of Dopamine D1 Receptor Activation in Overcoming Boundary Conditions for Object Identity and Object Location Memory Malleability
Consolidated long-term memories can be modified when a reactivation cue enables memory destabilization. Older and strongly encoded memories resist destabilization because of biological boundary conditions. Evidence suggests that a salient novel cue presented at reactivation can trigger …
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The Influence of Sustained CB1 Blockade During Adolescence on Breakpoints in a Progressive-ratio Paradigm
… antagonists. In these experiments, male Long-Evans rats were treated with SR141716A, a cannabinoid antagonist, throughout adolescence and allowed unrestricted access to food. Control groups were treated with vehicle during the same developmental period and allowed either unrestricted …
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Psychological and nutritional factors influencing the dynamics of gonadotrophin secretion in the female rat
… reproductive physiology of the female rat of the Long-Evans strain. Its objective was to determine whether the findings of controlled experiments provided support for existing hypotheses about the aetiology of amenorrhoea in anorexia nervosa. The relationship between alterations in body weight and …
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Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex
… prefrontal cortex was examined in both sexes of Long-Evans rats during five ages from postnatal day 25 to 90. Tyrosine hydroxylase-immunoreactive axon density was found to increase over the course of adolescence, with the most marked increases being prepubertal in both males and females. No sex …
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