Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"Long-Acting"”.
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Self-assembled peptide as a long-acting drug formulation
… Here I propose self-assembled peptides as a prolonged-activity, self-mediated drug delivery system for subcutaneous injection of pharmaceutically active drugs. Oxyntomodulin is used as a model peptide due to previously futile attempts at finding long-acting analogues, and Oxyntomodulin’s so far …
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Creating Recommendations for Long Acting Reversible Contraceptive Use for Adolescents
… for contraceptive counseling to include long acting reversible contraceptive (LARC) recommendations for the adolescent population. LARCs, which include intrauterine devices and implants, are the top-tier contraceptive for nulliparous women yet they are only used in less than 6% of women …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
In vitro release testing is pivotal in supporting various stages of pharmaceutical development, from formulation design to routine quality control. Its implementation ensures the consistent quality, performance, and regulatory compliance of medicinal products. For orally administered small-molecule …
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L'impatto degli antipsicotici long-acting sui marker della neuroinfiammazione associati alla schizofrenia
Diverse ricerche hanno suggerito una relazione tra schizofrenia e alterazioni del sistema immunitario, e in particolare nei livelli di citochine e chemochine. Le chemo-citochine sono proteine di segnalazione intercellulare, che svolgono un ruolo cruciale nella regolazione della risposta immunitaria …
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National Practices, Attitudes, and Training Surrounding Long-Acting Reversible Contraception Procedures for Adolescents
… counseling and lack training to administer long-acting reversible contraception (LARC), a highly effective form of contraception. Medically- and socially- complex patients access to contraception is additionally limited, as they often receive much of their medical care in the hospital …
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Evaluation of Long-Acting Eprinomectin Compared to Conventional Anthelmintics in Cow/Calf Production
… pour-on moxidectin and oxfendazole (MO); and 3) long-acting eprinomectin (LAE). Two preplanned orthogonal contrast statements were used: 1) to compare CON to treated cattle; and 2) to compare OXF to LAE. Heifer BW and BCS were greater (P≤0.02) from MO and LAE on d 112, 140, 154, 168, 182 compared …
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Depot medroxyprogesterone acetate versus norethisterone oenanthate for long-acting progestogenic contraception : a systematic review
[Background] Two injectable progestogen-only contraceptives (IPCs) depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-EN) continue to be extensively used in some countries, forming a large proportion of the health system's expenditure on contraception. Both these highly …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… skin and remain in the skin in a high level and long-acting way. Microneedles are a novel drug delivery technology that increase skin permeability by creating microscopic pores within the skin, thereby reducing the barrier to drug permeation. This thesis focuses on developing the novel polymeric …
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A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions
… on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare the duration and number of hospitalisation episodes 12 and 24 months before and …
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
… Mixed effects linear regression was used for longitudinal analysis and multinomial logistic regression was used to adjust for potential confounders that were assessed at baseline. Concentrations of IL-6 and MIP-3α were significantly higher in women enrolled at the Setshaba Research Centre …
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Improving Women’s Health Services by Adding Long-Acting Reversible Contraceptive Methods into Primary Care-Focused Student Health
… continues to be an issue in the United States. Long-acting reversible contraceptives, including intrauterine contraceptives and the subdermal contraceptive implant, are safe, effective, long-acting, easily reversible, and non-user dependent contraceptive methods, yet currently are greatly …
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Factors influencing the uptake of long acting reversible contraceptives among women at primary health clinics in eThekwini District
Submitted in fulfillment of the requirements for the Master of Health Sciences in Nursing, Durban University of Technology, Durban, South Africa, 2017.
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Biodegradable Polymeric Biomaterials in Different Forms for Long-acting Contraception and Drug Delivery to the Eye and Brain
… such as, injectable systems that can achieve long-term contraception (five months or longer) at low cost, and drug delivery systems that can enhance the permeability of drugs across ocular/blood-brain barriers and sustain release as well for treating chronic diseases such as diabetic …
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The Effect of Phosphodiesterase Inhibitors on the Induction of Gene Expression by Long-Acting beta2-Adrenoceptor Agonists and Glucocorticoids
… disease (COPD) patients who are already taking long-acting β2-agonists (LABA)/inhaled corticosteroid (ICS) combination therapy. However, this benefit is seen only in patients of the severe, bronchitic, frequent exacerbator phenotype. Several strategies have been proposed to enhance the clinical …
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
… *in vivo* up to few days. Despite to the prolong bioactivity of Oxm fibrils in subcutaneous (s.c.) space, the plasma half-life of Oxm peptide, upon release from the fibril, was short in serum due to the proteolytic degradation by DPP4, which limits the Oxm biological role. Furthermore, …
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A cost-utility and budget impact analysis of long-acting insulin analogues, (determir, glargine and degludec) for the treatment of adults with T1DM in South Africa
… with administered insulin. Intermediate- to long-acting insulin represents the basal insulin constituent of the total insulin used in treating T1DM and has received much research and development over the years. In South Africa, intermediate-acting Neutral Protamine Hagedorn (NPH) insulin has …
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Local Anesthetics in Post-Operative Endodontic Pain
… in patients with either an intermediate-acting local anesthetic (2% lidocaine with 1:100,000 epinephrine) or a long-acting local anesthetic (0.5% bupivacaine with 1:200,000 epinephrine). Twenty-one patients in need of emergency non-surgical endodontic treatment were included in this …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… strategies, including dual cART regimens and long-acting injectable treatments, on immune regulation and T-cell homeostasis. The research is structured around three key objectives: (1) investigating the HIV reservoir, circulating Th1/Th2 cytokines, gut integrity, and microbial translocation in …
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Injectable Systems for Long-Lasting Insulin Therapy
… 4-6 min which poses significant challenge in prolonging duration of action of insulin. Nevertheless, the advances in recombinant DNA technology and protein engineering have enabled the development of several long-acting insulin analogue products which show duration of action up to 42 h. However, …
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