Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Long noncoding RNA"”.
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The Regulation and Evolution of long, noncoding RNA Transcription
… leading to the production of thousands of long, noncoding RNAs (lncRNAs, > 200 basepairs), which are distinct from more traditional noncoding RNAs such as transfer RNAs or ribosomal RNAs. This striking finding is observed across all eukaryotes, from humans to budding yeast. It was once …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… extensively transcribed and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
… this study, I experimentally validated the novel long noncoding RNA up-stream of MYCN (lncUSMycN), which was originally annotated by bioinformatics analyses, within the 130 kb amplicon. Using rapid amplification of cDNA ends PCR, 140 extra nucleotides at the 5’-end of lncUSMycN were identified. …
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Functional Analysis of Risk Single Nucleotide Polymorphism and Long Noncoding RNA in Prostate Cancer
… element to dysregulate two gene isoforms of a long noncoding RNA (lncRNA) PCAT19. Furthermore, I validated the oncogenic properties of the lncRNA PCAT19, and revealed its function in prostate cancer progression through the upregulation of a subset of cell cycle genes with the RNA binding …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… cells initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular homeostasis and regulate stress responses. Previous work in the laboratory identified several microRNAs involved in regulating thymocyte responses to stress. …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… the AR) and Hox Transcript Antisense Intergenic RNA (HOTAIR) (a long noncoding RNA) can interact with the AR and are found to be elevated in CRPC. To investigate their effect on AR activity, luciferase reporter assays were performed. Results demonstrated that both factors can repress AR activity. …
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Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
… EZH2 and reciprocal action by the long noncoding RNA NKILA determine cellular response to therapeutic inhibition of NF-κB and EZH2. Thus, this knowledge critically informs the delivery of NF-κB-modulating adjuvants in breast cancer treatment. Finally, these findings and their …
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Improving multiplexed RNA detection assays by interfacing enzymatic amplification strategies with silicon photonic microring resonators
… 2 gives an exhaustive review of current microRNA (miRNA) detection platforms, both clinical gold standards and emerging technologies. Given the unique detection challenges of microRNAs, this class of RNA molecule was used to develop a detection platform which could then be translated to other …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… hormones and signalling factors that adapt maternal metabolism to support fetal growth. In mice, these functions are performed in two distinct placental regions, the transport labyrinth zone (Lz) and the endocrine junctional zone (Jz). Insulin like growth factor 2 (Igf2) is a growth-promoting …
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Development of Oligonucleotide-directed proximity-interactome MAPping (O-MAP), for characterizing RNA-protein interactions and higher order subnuclear architecture in situ
RNA-protein interactions underscore a broad array of regulatory mechanisms throughout biology, and dysregulation of these interactions contributes to a broad range of human pathologies such as neurodegenerative disorders and many cancers. Recent studies have discovered thousands of RNA-binding …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… Thousands of these transcripts are classified as long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides, but very few have been functionally characterized. Here, I detail a journey of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… <p>The first centers on how obesity-driven noncoding RNA dysregulation suppresses NK cell fitness and renders cellular immunotherapy ineffective. To identify circulating mediators of obesity-associated immune suppression, snoRNA expression was profiled in human serum across a range of BMI …
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Transcript Regulation within the Kcnq1 Domain
… as DNA methylation and histone modifications along with stable expression of non- coding RNAs. Within the realm of epigenetics is a phenomenon known as genomic imprinting. Imprints are marks that distinguish the maternal from the paternal chromosomes in the form of methylation. Methylation …