Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Long non-coding RNAs"”.
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Role of long non-coding RNAs in breast cancer progression
… that the majority of genome is transcribed into non-protein coding RNAs (ncRNAs), including thousands of long ncRNAs (lncRNAs). At present, we do not know the biological function of majority of these lncRNAs. MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a lncRNA which its …
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… regulation with the discoveries of functional non-coding ribonucleic acids (RNAs). In recent years, the number of studies in the field of long non-coding RNA (lncRNA) biology has increased dramatically. Transcriptomic analyses of the eukaryotic genome revealed that the genome is pervasively …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
Mammalian genomes comprise thousands of non-protein-coding genes. These can produce small non-coding RNAs (such as rRNAs and tRNAs), as well as long non-coding RNAs (lncRNAs), which are >200nt and resemble mRNAs in their biogenesis. Although the functions of the vast majority of lncRNAs remain …
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Caracterització estructural i funcional de long non-coding RNAs (lncRNAs) en nematodes
… l'expressió genètica i que tots els gens dels lncRNAs amb els quals interaccionen es troben en coordenades allunyades.
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Investigating the Role of Viral Long Non-Coding RNAs During Human Cytomegalovirus Latency
… is never cleared and can go on to establish lifelong latency in cells of the early myeloid lineage. During latency, the virus reduces its gene expression programme and produces no infectious progeny virus, but maintains the ability to reactivate and cause a full lytic infection. In vivo, sporadic …
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Conservation and synteny of long non-coding RNAs invertebrate genomes and their identification in novel transcriptomes
Long non-coding RNAs (IncRNAs) are a biological entity defined by <i>what they are not</i>, rather than by <i>what they are</i>. This indicates that our knowledge about them is sensibly limited. The aim of my PhD is to gain insights into the evolution and the functions of IncRNAs through …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… (HDT) has recently gained attention, with long non-coding RNAs (lncRNAs) as potential targets due to their emerging roles in pathogenic immune responses. We previously performed cap analysis gene expression (CAGE) transcriptomics on IFN-γ stimulated (classically activated) and IL-4/IL-13 …
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The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
… UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of …
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Role of lncRNA in cancer development and progression
PART1, TITLE: A p53-inducible long non-coding RNA PICART1 mediating cancer cell proliferation and migration. Long non-coding RNAs (lncRNAs) function in the development and progression of cancer, but only a small portion of lncRNAs are characterized thus far. A novel lncRNA transcript with 2.53 kb …
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LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
… regulated by various modulators including long non-coding RNAs (lncRNAs), which influence gene expression and cardiac cell fate. This thesis focuses on verifying and characterizing of one key lncRNA, VENTHEART (VHRT), which was identified as one of the top upregulated markers in …
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The impact of the Human papillomavirus type 16 on non-coding RNAs in Head and Neck cancer
… is the cause for 90% of all HPV related OPCs. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been shown to have dysregulated expression in OPC. The dysregulated expression on ncRNAs can lead to tumour development. The aim of this study was to …
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From genotype to phenotype: novel methodologies for the discovery of new pathological biomarkers in human
… analysis techniques related to microRNAs in Papillary Thyroid Carcinoma and to long non-coding RNAs in Diffuse Large B-cell Lymphoma. Chapter 3 explains the debated competing endogenous RNA mechanism of post-transcriptional regulation and presents CERNIA, a machine learning framework …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… Thousands of these transcripts are classified as long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides, but very few have been functionally characterized. Here, I detail a journey of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… In addition, an investigation of long non-coding RNAs reveals that CYTOR contributes to these stiffness-driven changes in gene abundance. Knockdown of CYTOR using antisense oligonucleotides enhances the expression of numerous mechanoresponsive cytokines and chemokines to levels …
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Investigating the role of HOTTIP, HOXA13 and PSIP1 in cancer.
… and progression, and therapy resistance. Long non-coding RNAs (lncRNAs) have gained attention in recent years as potential therapeutic targets for cancer. HOTTIP is one such lncRNA that has previously been implicated in CRC and PCa. HOTTIP is located on the 5’ end of the HOXA locus and …
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IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis
… resistance to current antimicrobials. Non-coding RNAs are emerging as important regulators of numerous biological processes and avenues for exploitation in host-directed therapeutics. Although long non-coding RNAs (lncRNAs) are abundantly expressed in immune cells, their functional role …
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Molecular and systems-level analyses reveal the emerging role of non-coding RNAs in liver diseases
… body. Thus, the liver is prone to many diseases. Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, is an umbrella term for a range of conditions compromising hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis without alcohol consumption, which …
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Preparation, Characterization, and Delivery of Antibodies Binding to a Model Oncogenic RNA, Human Initiator tRNA
<p>Non-coding RNAs (ncRNAs) account for a higher percent of the genome than coding mRNAs, and are implicated in human disease such as cancer, neurological, cardiac and many others. While the majority of ncRNAs involved in disease were originally attributed to a class of RNAs called micro RNAs …
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