Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Lomustine"”.
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Metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites and O6-methylguanine-DNA methyltransferase expression in canine cells
The nitrosourea drug lomustine is used clinically for treating a wide variety of malignancies, most commonly brain tumors and lymphoma. Lomustine undergoes hydrolysis in vivo to form isomeric metabolites, primarily trans-4-hydroxylomustine (trans-4) and cis-4- hydroxylomustine (cis-4) in various …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… used chemotherapy drugs (vinca alkaloids and lomustine) together to determine their effectiveness at killing canine histiocytic cells in culture. The results obtained in the first cell line studied did not show a difference in the effectiveness of these drugs when combined compared to when …
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Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells
… [(l-(2-chloroethyl)-3-cyclohexyl-lnitrosourea,Lomustine]. This is a well established clinically used lipophilic anticancerdrug. This drug crosses the blood brain barrier and is used routinely for the treatment ofcertain types of brain tumours, in particular in childhood malignancies e.g. …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… with the conventional GBM drugs such as TMZ, Lomustine (CCNU) and Carmustine (BCNU), showed synergistic cytotoxicity and sensitized the GBM cell lines to first line drugs tested in this study. This study further explored the possible mechanisms of action of DMSA+Cu such as generation of …
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The impact of cytotoxic chemotherapy on somatic mutation in normal human cells
… SBS signatures associated with mitomycin C, lomustine/carmustine, busulfan and thiotepa, alongside a DBS signature of mitomycin C and an indel signature associated with a broad range of platinum-based and alkylating agents. Additionally, indel signatures of topoisomerase II inhibitors and …