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Showing 1 to 1 of 1 for “"Lometrexol"”.
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Single Nucleotide Polymorphisms in the Folypoly-gamma-glutamate synthetase Gene
… of cancer chemotherapy, antifolates, such as Lometrexol and Tomudex are retained in cells through the activity of FPGS. Consequently, any single nucleotide polymorphisms (SNPs) that exist in the fpgs gene may decrease or increase the cytotoxicity of antifolates and, ultimately, the clinical …