Global ETD Search
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Showing 1 to 2 of 2 for “"Locus control region"”.
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs). The region encompassing HSI and HSII contains the predominant pituitary somatotrope-specific hGH-N activation function of the LCR. This activity was …
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Genomic Characterization of Sickle Cell Mouse Models for Therapeutic Genome Editing Applications
… of a TGACC nucleotide motif within this region by Cas9-mediated non-homologous end joining in human erythroid cells or their progenitors caused induction of HbF by interfering with recruitment of the transcriptional repressor, BCL11A. This strategy results in potent HbF induction in human …