Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Locoregional"”.
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Optimizing Locoregional Anesthesia for Fast Track Orthopedic Surgery
Contains fulltext : 209501.pdf (Publisher’s version ) (Open Access)
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
Locoregional treatment is the specific delivery of therapeutics to their desired sites of action with minimized systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in …
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LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
Tumor cell growth, even in advanced stages of ovarian cancer, is nearly always restricted to the peritoneal cavity, therefore repeated intraperitoneal injections of CpG-ODN recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell …
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Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
… has been considered the primary method of locoregional therapy for dogs undergoing TPLO, the development of peripheral nerve blocks has been a rapidly growing area of veterinary research. An in-depth knowledge of the pain cycle and ways to intervene in nociception is an immense area of …
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Population-based outcomes in pancreatic cancer: Improvements in survival, underutilization of surgical resection for early stage disease, and regionalization of care
… the use of surgical resection in patients with locoregional pancreatic cancer, fewer than one third of patients undergo surgical resection. The reasons for underutilization of surgical resection were further evaluated. In the SEER-Medicare population, only 75% of patients with locoregional …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… are often used to reduce systemic and locoregional recurrence, respectively, after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response …
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Deep Learning and Radiomics Based Outcome Prediction for Cancer Patients
… head and neck cancer (HNC) patients for locoregional recurrence (LRR) before radiotherapy using clinical data and PET/CT imaging. In addition, we developed a DL segmentation model to guide the extraction of radiomics features for HNC recurrence-free survival (RFS) prediction using data …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
Despite significant improvement in locoregional control in the contemporary era, nasopharyngeal carcinoma (NPC) patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. …
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Engineered Nanomaterials for Targeted Imaging and Therapy
… polymeric nanoparticle to deliver drugs for the locoregional treatment of head and neck squamous cell carcinoma (HNSCC). In chapter 4, a HA-pyropheophorbide a (PPa) conjugate was synthesized. The anti-cancer efficacy was improved compared to the intravenously administered PPa molecules, and it …
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Trends in Receipt and Timing of Multimodality Therapy in Early Stage Pancreatic
… and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regards to age and treatment center in the receipt of multimodality therapy. METHODS: We used the National Cancer Data Base to identify patients >18 years old with stage I …
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Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
… and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the receipt of multimodality therapy. Methods We used the National Cancer Data Base to identify patients ≥18 years old with stage I and …
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Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
… and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the receipt of multimodality therapy. Methods We used the National Cancer Data Base to identify patients ≥18 years old with stage I and …
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Hospital and Medical Care Days in Pancreatic Cancer
… of duration of survival. In patients with locoregional disease, resection was associated with a higher number of hospital/medical care days during the first 4 months after diagnosis, but fewer at the end of the first year. For distant disease, hospital days were similar but days in medical …
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Zeta-Ketten Expression bei Patienten mit SCCHN und dendritische Zellen als Stimulatoren für T-Zellen In Vitro
… occurs in early tumor stages. Additionally to locoregional approaches future therapeutic strategies should also focus on systemic immunemodulation.
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… the effectiveness oftreatment. A promising locoregional treatment that can induce tumor necrosis and modify the TME is endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA). However, there is still minimal understanding around its wider impact on stromal remodeling and immunological …
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
… doses of ionizing radiation to achieve locoregional tumour control, while minimizing normal tissue toxicity. A greater therapeutic ratio can be achieved by utilizing radiosensitizing agents designed to enhance the effects of radiation at the tumour. Gold nanoparticles (AuNP) represent a …
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
… in the 5 year survival rates, mainly due to locoregional recurrences and to a lesser extent, distant metastasis.The role of anti-tumour immunity in relation to HNSCC has been intensely studied in the past few years. It is now becoming clear that the complex interaction between HNSCC and …
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Developing an evidence based approach to follow up in breast cancer
… up is provided with a view to early detection of locoregional relapse, detection and amelioration of side effects of therapy and provision of psychosocial support to those requiring it. There is pressure within the United Kingdom from the National Institute for Clinical Excellence (NICE) to reduce …
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Reactive Oxygen Species and P21 Waf1/Cip1 Are Both Essential For
… The efficacy of radiotherapy in controlling locoregional recurrence, the most frequent cause of death from HNSCC, is critically important for patient survival. One potential biomarker to determine radioresistance is <em>TP53</em>, whose alterations are predictive of poor radiation response. …
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