Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Local field potentials"”.
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Investigation of Spatio-Spectral Dynamics of Local Field Potentials in Parkinson’s Disease
… cannot be controlled with medications. Accurate localization of STN is an important factor defining the efficacy of DBS. The most common targeting method in DBS surgery is the microelectrode single unit activity recording, which is performed by listening to bursting firing patterns of individual …
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Time-varying phase relationship between spiking neuronal responses and local field potentials in olfactory processing in manduca sexta
… on the coincidence of their spiking relative to local field potential (LFP) oscillation phase. Using the sphinx moth, Manduca sexta, as a model system, we tested the predictions of the TOM with regard to the trial-to-trial consistency of odor driven oscillations, the phase-locking of action …
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Adaptive Detection of Beta Bursts of Local Field Potentials Recorded from Subthalamic Nucleus in Patients with Parkinson’s Disease
… expected to increase within the following years. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) leads placed into the motor territory of the subthalamic nucleus (STN) can be used to investigate the mechanism of PD and allows for further development of new therapeutic …
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Simultaneous Behavior Onset Detection and Task Classification for Patients with Parkinson Disease Using Subthalamic Nucleus Local Field Potentials
… PD patient. The detection is based on recorded Local Field Potentials (LFP) of the Subthalamic nucleus (STN), captured through Deep Brain Stimulation (DBS) process.</p> <p>One main part of this work is dedicated to the research of various properties and features of the STN LFP signals of several …
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Large-scale neural recordings and biophysical models for inferring network mechanisms of ketamine anesthesia
… to support unconsciousness. First, I analyze local field potentials and single unit activity from ketamine anesthesia in non-human primates to show that the neocortex under ketamine is hyperactive based on all common measures of neural activity. Furthermore, I demonstrate that spiking …
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Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease
… pathways, and reduced ATP production. Local field potentials recorded from three regions of the ascending visual pathway showed complex changes in the beta- and gamma-band power and in the coherence between these regions. MPTP treatment produced significantly impaired movements which …
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Design of High-Resolution SAR ADC for Detection of Sub-Cortical Neuron Action Potentials for BMI Applications
… of resolving both fast, low-amplitude action potentials (APs) and slow, higher-amplitude local field potentials (LFPs) under stringent power and area constraints. This thesis presents the design and simulation of a high-resolution, low-power successive approximation register (SAR) …
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Dynamics of dopamine signaling and network activity in the striatum during learning and motivated pursuit of goals
… revealed training dependent dynamics in striatum local field potentials and coordinated neural firing that may differentially support both network rigidity and flexibility during pursuit of goals. Electrochemical measurements of real-time dopamine signaling during maze running revealed prolonged …
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Understanding Autonomic Control via Human Deep Brain Stimulation
… as well as measurement of electrical activity (local field potentials (LFPs)) to assess whether a nucleus is integral to a specific change in autonomic output. The sum of my work outlined in this thesis demonstrates that common DBS targets such as subthalamic nucleus (STN) and pedunculopontine …
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An ultra-low-power neural recording amplifier and its use in adaptively-biased multi-amplifier arrays
… adjusted for recording either neural spikes or local field potentials (LFP). When configured for recording neural spikes, the amplifier yielded a midband gain of 40.8 dB and -3 dB bandwidth from 45 Hz to 5.32 kHz; the amplifier's input-referred noise was measured to be 3.06 [mu]Vrms, while …
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The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes
… I first examined their effects on hippocampal local field potentials in urethane-anaesthetised mice. I demonstrated that optogenetic cholinergic activation suppressed slow oscillations, shifting brain activity to a state dominated by theta and gamma oscillations. In contrast, dopaminergic …
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Beta oscillations in frontal cortex and striatum represent post-processing of successful behavior
… role of beta activity in the brain, we recorded local field potentials in the frontal cortex and striatum of monkeys as they performed single and sequential arm movement tasks. To facilitate these experiments, we developed novel methods for recording simultaneously from independently moveable …
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Investigation of the multiple-demand network at multiple spatial scales
… at the voxel level. MD regions were equally well localised in single-subjects using any of three task demands. Voxels localised by all three tasks also captured the underlying neural representations to a similar level in a separate criterion task. Chapter 4 investigated if task representations, as …
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Neural dynamics of the anesthetized brain and the control of conscious states
… consciousness, we measured spiking activity and local field potentials (LFPs) from multiple cortical and thalamic regions while monkeys were pharmacologically rendered unconscious. In Chapter 2, we examine effects of the GABAergic anesthetic propofol across prefrontal cortices (PFC), parietal …
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Spiking and oscillatory correlates of visual short-term memory for multiple items
… Here, we measured neural activity in a change localization task, in which monkeys viewed two displays of multiple colored squares separated by a brief delay, and made a saccade to the square that changed color between displays. In chapter 2, we examine local field potentials in the lateral …
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Phenotypic And Electrophysiologic Characterization of a Mouse Model of Fragile X Syndrome
… mice. Single and multi unit spike activities and local field potentials (LFPs) were recorded in the whisker barrel cortex of awake mice. Baseline spike activity was significantly lower in cortical neurons of Fmr1 KO mice. Synchronous activity at the LFP was strongly reduced in Fmr1 KO mice. …
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The Role of the Dorsal Premotor and Superior Parietal Cortices in Decoupled Visuomotor Transformations
… recorded the neural activity (single units and local field potentials) within each region while the animals performed each condition. We found that two separate networks emerged each contributing in a distinct ways to the performance of coupled versus decoupled eye-hand reaches. While PMdr and …
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Employing Intracranial EEG Data to Decipher Sleep Neural Dynamics
… and to detect single unit activity and local field potentials, thus providing a level of physiological detail normally available only in animal studies. In this thesis we employ intracranial data to advance our understanding of sleep neural dynamics in humans, and to this end its focus …
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Simultaneous activation of multiple memory systems during learning : insights from electrophysiology and modeling
… brain regions. In a second set of experiments, local field potentials (LFPs) were recorded simultaneously from the dorsal striatum and the CAl field of the hippocampus, as rats engaged in spontaneous and instructed behaviors in the T-maze. Two major findings are reported. First, striatal LFPs …
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Dynamics and precursor signs for phase transitions in neural systems
… spiking neurons, a network of these, and a mean-field continuum limit) and in vitro experiments to address this question. Dynamically realistic equations of motion for thalamic relay neuron, reticular nuclei, cortical pyramidal and cortical interneuron in different vigilance states are developed, …
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