Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Local drug delivery"”.
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Local drug delivery for treatment of brain tumor associated edema
… for normal physiological functions. A miniature drug delivery device was developed for local drug delivery in rodents. It comprises of a drug reservoir and a cap with orifice(s) through which drug is released. Drug release kinetics is dependent on the payload, the drug solubility, and the surface …
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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A biocompatible, local drug delivery platform for the chronic treatment of neurological disorders of the brain
… deliver nanoliter scale volumes (10-1000 n1) of drug to targeted brain structures over the course of an eight week implantation period. Muscimol was delivered to deep brain structures to demonstrate effective modulation of neural activity and behavior. These findings highlight the utility of a …
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Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs
Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for studying skeletal muscle biomechanics typically use: mounting techniques that …
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Development of Novel Thermosensitive Polymers for Bioresponsive Drug Delivery
… promise in controlled and self-regulated drug delivery. Successful construction of responsive polymers requires amalgamation of chemical, physical and biological principles. For careful therapy, a great deal of advantages offered by stimuli-responsive polymers is essential. A small or …
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Evaluation & design of a novel drug delivery device for treating tumor-related cerebral edema
… and the latter is an ineffective option. Local drug delivery to the desired site of therapy helps to circumvent the side effects of DXM. In this paper, the design of a novel, local drug delivery device was explored as a means to treat tumor-related cerebral edema. The novel device was then …
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Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery
Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases that plague the inner ear. The real-time controlled linear Lorentz-force …
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Development of porous delivery systems for oral drug and vaccine administration
… implants for structural purposes as well as for local drug delivery. Several manufacturing techniques for porous ceramics are reviewed and the drug release from these porous devices is described. Chapter 1 also summarizes the most important aspects of the manufacturing and formulation of …
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Reservoir-based devices for the monitoring and treatment of disease
… despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid tumors and their response to …
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Packaging for a drug delivery microelectromechanical system
Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. A silicon microelectromechanical drug delivery device was fabricated for …
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The role of cell division during tissue morphogenesis
… in a PLK1- and PLK4-dependent manner. Lastly, a local drug delivery system was developed in zebrafish embryos to target a PLK1 inhibitor to the centrosome. Through this system, it was revealed that centrosomal PLK1 is responsible for spindle organization and mitotic progression in zebrafish …
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Polymer Based Delivery Of Doxycycline Hyclate For The Prevention Of Peri-Implant Mucositis Infection
… debridement with or without the use of local drug delivery systems. However, these treatments do not solve the problem of implant rejection as peri-mucositis progresses to per-implantitis which causes severe bone loss and ultimately leading to implant rejection thus causing a great …
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A materials-based approach for localized delivery of cancer immunotherapy
… a safe, tumor-agnostic approach to improve local and systemic anti-cancer immunity. This thesis also contains abundant discussion about the potential disadvantages of persistently-retained IL-12 along with solutions to circumvent the obstacles while maintaining the high therapeutic-index …
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Quantification of myocardial macromolecular transport
The needs and impacts of drug administration have evolved from a systemic to a local focus. Local drug delivery would allow a higher local drug concentration at lower systemic toxicity than what can be achieved if delivered systemically. One of the tissues of interest for local delivery is the …
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Thermal spray of a drug delivery system onto femoral orthopaedic implant
… (infections) behaviour. It is thought that local drug delivery would be useful to prevent implant failures that could be treated with therapeutic agents (drug/growth factor). It is hypothesised in this work that polymers proven in drug delivery for other applications could be successfully …
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Engineering translational vaccine delivery systems with the polyphenol tannic acid
… interactions, represent an exciting frontier in drug delivery due to their ease of formulation and modularity. Tannic acid (TA) is a naturally-occurring compound that has a demonstrated ability to engage in supramolecular interactions with biological cargo, including proteins, nucleic acids, and …
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Novel Diagnostics and Therapeutic Approaches for Supratentorial Ependymoma
… preclinical testing. Screens of FDA-approved drugs produced candidate drugs for repurposing. As these compounds display unfavourable blood-brain barrier penetrability, they were combined with a local delivery system. For this, a biodegradable hydrogel system was optimised and implemented into …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
<p>Current advances in the drug delivery have improved the therapeutic efficacy of the drug and minimized risks of side effects associated with toxicity of the drug. Implantable polymeric delivery system has gained increasing attentions for controlled drug release and localized treatments. In …