Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Local ancestry"”.
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Investigating local ancestry inference models in mixed ancestry individual genomes
… Known admixed populations include the mixed ancestry of South Africa, Latin Americans and African Americans. Admixed individuals play important roles in understanding population history, disease aetiology, and personal genomics. Accordingly, efforts have been made to understand the genetic …
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Painting the Past: Uncovering Ancestral Contributions to Complex Human Phenotypes in Western Eurasia
… To achieve this, methods were developed to infer local ancestry in a large modern panel, the UK Biobank, using new ancient reference genomes. Modern samples were selected based on a ‘typical ancestral profile’ for each country represented in the UK Biobank. This dataset was then used to infer the …
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Applying ancestry tracts to human genetics: disentangling admixture history and characterizing gene conversion
Local ancestry is central to a variety of inference problems in population and medical genetics. Here I propose new methods for studying admixture demography and inferring non-crossover gene-conversion from admixture tracts. First, I present PAPI (Parental Admixture Proportion Inference), a …
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Ancestral Paths: Redefining local genetic ancestry and its inference with application to Europeans
… In this thesis I present a new method to infer local ancestry along sample chromosomes. The method applies machine learning to tree sequences built from ancient and present-day genomes and is based on a deterministic model of population structure, within which I introduce the concept of ‘path …
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Genetic inference of deep hominin evolutionary history using the sequentially Markovian coalescent
… The method also allows posterior estimates of local ancestry, in that we can infer which ancestral population a genomic region descends from. When applied to real data, cobraa suggests an extended period of structure in the history of all modern humans, in which two ancestral populations A and …
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Admixture Mapping of Subclinical and Clinical Cardiovascular Disease among African Americans
… dissertation is to evaluate the association of local European ancestry (LEA) with subclinical and clinical cardiovascular (CV) disease (CVD) among African Americans in three prospective cohorts from the United States. CVD burden is higher among African Americans compared to other racial/ethnic …