Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Local Delivery"”.
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Local delivery service opportunities in e-commerce
This is a study of the local package delivery industry. This thesis shall consider only businesses that are engaged in delivery of goods and services that have been purchased online. Such companies may or may not be engaged in other business activities aside from delivery. Local refers to …
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Controlled local delivery of RNA : regulating tissue morphogenesis
… the body, it is highly immunogenic, and systemic delivery is complicated by high clearance rates. As such, developing formulations for the effective delivery of short RNAs presents significant hurdles. Local delivery can limit numerous unwanted systemic side effects of therapies and it maintains …
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Liposome-anchored local delivery of immunomodulatory agents for tumor therapy
… retain the bio-activity of therapeutics in the local tumor tissue and tumordraining lymph node, but limit systemic exposure to these potent molecules. We first prepared liposomes bearing surface-conjugated anti-CD40 and CpG and assessed their therapeutic efficacy and systemic toxicity compared …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
… carriers or through fibrin surface-mediated delivery of siRNA targeting rhBMP-2 antagonists. For this reason, we developed an alternative natural polymer rhBMP-2 carrier from keratin. Keratin can be formed into a number of biomaterials which have advantages over collagen including controlled …
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Protein and peptide-based biomaterials for treatment of COVID-19, crossing the blood-brain barrier and local delivery of antibiotics
… the need to find ways to deliver antibiotics locally to prevent surgical site infections. The problem statement and objectives of the dissertation were also outlined in this chapter. In Chapter 2, we first reviewed the structure, mechanism of host infection, and various therapeutic strategies …
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From national development to local delivery: how neighbourhood policing policy and guidance has informed the understanding of communities and engagement practice at a local level
… practitioners, and the review of national and local policy documents. Such an approach informed understanding of the policy development and implementation journey. The theoretical background of this study is based in Kingdon’s (2011) concepts of policy streams and policy entrepreneurs as well …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… portal to external environment and suitable for local delivery. Additionally, oral inhalation (OI) has long been accepted as the preferred mode of administration of therapeutics to the lungs. To address these discussed challenges, we used a strategy — polymeric nanocarriers (PNCs) to achieve the …
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Local exposure and efficacy of a reservoir-based drug delivery device
… time by only a few months. Efforts to develop local treatment modules are motivated by the fact that patients experience systemic toxicities during conventional treatment. Implantable Gliadel® BCNU wafers were approved by the FDA, but patients still experienced side effects such as edema, and …
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Myd88 Mediated Anti-Fibrotic Effects of Folic Acid Treatments in Management of Drug-Induced Gingival Overgrowths
… Further, prior studies had noted efficacy of local delivery of folic acid (FA) in managing DIGO treatment. Based on these observations, this thesis examined the role of Myd88 in mediating folic acid treatments for DIGO in an animal model and human patient samples. This work developed a novel …
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Preclinical Evaluation of a Novel Polysaccharide Hydrogel for Local Chemotherapy Delivery to Solid Tumors
<p>Local delivery of chemotherapeutic agents directly to tumor sites has great advantages over traditional and emerging drug delivery technologies. Local delivery of compounds increases drug concentration at the target site, decreases drug effects on non-target tissues, and protects the drug from …
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Signalling to intracellular Ca2+ channels
… Ca$^{2+}$ release via a mechanism that required local delivery of cAMP to IP$_{3}$ receptors (IP$_{3}$R) within signalling junctions. My aim was to establish whether the interaction between adenylyl cyclase (AC) and IP$_{3}$R persists during sustained stimulation with PTH, which has been reported …
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Development of Implantable Optical Fibers for Immunotherapeutics Delivery and Tumor Impedance Measurement
… patient-response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not …
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Drug delivery device for bladder disorders
… discomfort. An alternative, site-specific local delivery approach was created using a reservoir-based drug delivery device. This novel passive device was designed to release drug in a predetermined manner once inside the bladder. The device also possesses a retention feature to prevent …
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Towards MRI-Guided and Actuated Tetherless Milli-Robots
… MR scanner to maneuver ferromagnetic agents for local delivery of therapeutics. With this approach, MRI is both a sensor and forms a closed-loop controlled entity that behaves as a robot (we refer to them as MRbots). The objective of this thesis is to introduce a computational framework for …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… drug uptake in the arterial wall. In this work local delivery of a hydrophobic drug from a drug-eluting stent implanted in a coronary artery is investigated using a mathematical model that couples drug diffusion and reversible binding in the arterial wall. The model is solved by the finite …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… critically whether the lack of late efficacy of local delivery of angiogenic factors could be explained by a comprehensive understanding of local pharmacokinetics (PK) and pharmacodynamics (PD) in the myocardial tissue. Our central hypothesis is that early success at inducing vessel growth …
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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Development Of Strontium-Alginate Scaffolds To Improve Gingival Fibroblast Function
… strontium alginate rings scaffolds serving as a local reservoir for local delivery of strontium to the affected dental implant and to test the cytotoxicity and the release of strontium material in cell culture model of human gingival fibroblast cells. Materials and Methods: Specially designed …
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Langzeituntersuchung zur In-Stent-Restenose eines neuen biodegradierbaren, wirkstoffbeladenen, intravaskulären Polylaktidstents nach Implantation in porcine Koronararterien
… proposed as surrogate materials for stents and local delivery systems for drugs. Paclitaxel was shown to inhibit vascular smooth muscle cell proliferation and migration. A novel biodegradable double-helical stent was manufac-tured using controlled expansion of saturated polymers (CESP) for the …
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