Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"LncRNA"”.
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Role of lncRNA in cancer development and progression
… and migration. Long non-coding RNAs (lncRNAs) function in the development and progression of cancer, but only a small portion of lncRNAs are characterized thus far. A novel lncRNA transcript with 2.53 kb in length was identified by a transcriptome sequencing analysis, named …
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LncRNA discovery in the Listeria monocytogenes infection model
… of evidence indicates that long noncoding RNAs (lncRNAs), the most abundant noncoding RNA (ncRNA) species of the pervasively transcribed mammalain genome, have functional roles in the gene regulation of an array of cellular processes. These observations have since discredited the long standing …
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… RNAs, particularly long non-coding RNAs (lncRNAs), are still being elucidated, with new functions continuously emerging as the filed advances. In recent years, several technologies have been developed to study RNA-chromatin interactions at a genome-wide scale, including RNA And DNA …
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LncRNA Nostrill Facilitates Neuronal Antiviral Responses by Promoting NFkB-Mediated Irf7 Transcription
… of neurodiseases. Long non-coding RNAs (LncRNAs) are key cell-specific regulators of gene transcription and are differentially expressed in antiviral responses and neurodegenerative diseases. The purpose of this study was to explore the role of the novel lncRNA Nostrill in neuronal …
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lncRNA RPPH1 in melanoma: novel functions as cargo of tumor-derived Extracellular Vesicles
The long non-coding RNA (lncRNA) RPPH1 is a ribozyme, an RNA molecule with enzymatic activity, and serves as the catalytic component of the RNase P ribonucleoprotein complex. This complex performs the endonucleolytic cleavage of precursor tRNAs at their 5′ leader sequences. Increasing evidence …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
Previous studies have demonstrated that the physical properties of biomaterials can be adjusted to program therapeutically relevant functions in encapsulated mesenchymal stromal cells (MSCs). However, the intracellular pathways affected by mechanical cues in this cell type have not been thoroughly …
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… little is known about long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which seem to act through a plethora of molecular mechanisms regulating essential biological processes, such as cell cycle, splicing, chromatin remodeling, apoptosis, adhesion and migration. LncRNAs are …
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Investigating the roles of lncRNA TERRA in telomerase-to-ALT transition using cancer cell lines and multicellular organisms
… is the presence of high levels of telomeric lncRNA TERRA, which is thought to play a role in HR during ALT. However, little is known about the involvement of TERRA in the onset of ALT. In this PhD project, we aim at investigating the roles of TERRA in ALT and during telomerase-to-ALT …
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… of studies in the field of long non-coding RNA (lncRNA) biology has increased dramatically. Transcriptomic analyses of the eukaryotic genome revealed that the genome is pervasively transcribed and contains a vast number of lncRNA transcripts, most with unknown functions. Although relatively …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… gained attention, with long non-coding RNAs (lncRNAs) as potential targets due to their emerging roles in pathogenic immune responses. We previously performed cap analysis gene expression (CAGE) transcriptomics on IFN-γ stimulated (classically activated) and IL-4/IL-13 stimulated …
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Exploring the Role of Long Non-Coding RNA in Neural Stem Cell Reactivation from Quiescence: A Functional Genomics Approach
Given the proposed role of long non-coding RNA (lncRNA) in fine-tuning large-scale genomic responses to stimuli and cell-fate transitions, previous members of the Brand lab compared genome-wide changes in DNA polymerase II occupancy at lncRNA loci during Drosophila melanogaster neural stem cell …
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The role of long non-coding RNA LINC00673 in lung tumorigenesis
… explores the roles of long non-coding RNA (lncRNA) in the progression of lung adenocarcinoma (LUAD) – the most common type of lung cancer – to improve current understanding of the disease. Using a combination of computational and wet-lab approaches, we identified LINC00673 as a potential …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA that is required for …
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New Microfluidic Technologies for Studying Histone Modifications and Long Non-Coding RNA Bindings
… ChIRP-seq assay to profile genome-wide lncRNA binding for numerous human diseases. We used 20,000 and 50,000 primary cells to study histone modifications in inflammation and breast cancer of BRCA1 mutation, respectively. In the project of whole-genome lncRNA bindings, our microfluidic …
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Non-Coding Rnas Identify The Intrinsic Molecular Subtypes of Muscle-Invasive Bladder Cancer
… RNAs (ncRNAs), both short (miRNA) and long (lncRNA), in the regulation of various biological processes involved in cancer development and progression. The molecular mechanisms of miRNAs are relatively straightforward by inhibiting their mRNA targets, but the molecular mechanisms of lncRNAs …
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Conservation and synteny of long non-coding RNAs invertebrate genomes and their identification in novel transcriptomes
… me to show, for the first time, the presence of lncRNA transcription in a diverse range of organisms. Further, I analysed sequence and positional conservation of lncRNAs, demonstrating the presence of short segments of conserved sequence in IncRNAs and the existence of several syntenically …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… are classified as long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides, but very few have been functionally characterized. Here, I detail a journey of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, beginning from the …
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Caracterització estructural i funcional de long non-coding RNAs (lncRNAs) en nematodes
Els lncRNA són gens que al no codificar per proteïnes i estar poc conservats a nivell de seqüència, necessiten tècniques d'anàlisis diferents de les utilitzades per estudiar gens que sí que codifiquen proteïnes. Aquest fet suposa un repte i una oportunitat per impulsar l'ús de noves tècniques …
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Exploring the camouflaged and non-coding genome: analysing difficult genomic regions in human disease genetics
… this thesis characterizes a long non-coding RNA (lncRNA) originating from the segmentally duplicated Pregnancy-Specific Glycoprotein locus. The lncRNA was expressed exclusively in oligodendrocytes, implicating it in the regulation of myelination processes in the brain. This lncRNA is …
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Enabling the in vitro study of long noncoding RNAs to understand their role in Plasmodium falciparum
Long noncoding RNAs (lncRNAs) have been identified in *Plasmodium falciparum*, the parasitic cause for life-threatening malaria, yet their role remains largely undiscovered. Through interactions with nucleic acids and proteins, lncRNAs can modulate gene expression at the transcriptional, …
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