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Showing 1 to 4 of 4 for “"Lmx1b"”.
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Mechanism of Lmx1b-regulated Limb Dorsalization
Lmx1b, a LIM homeodomain transcription factor is necessary for limb, kidney, eye, and central nervous system development. Lmx1b knockout (KO) mice display; abnormal limb dorsalization with distal ventral-ventral limbs, nephropathy, ocular malformations, loss of dopaminergic/serotonergic neurons, …
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Detailed analysis of Lmx1b expression in multiple organs and its role in dorso-ventral patterning with emphasis on myogenic precursor cells
Lmx1b belongs to a family of LIM homeodomain transcription factors expressed in multiple organs. Targeted disruption of Lmx1b results in ventralization of the limbs, skeletal, brain, kidney and ocular defects which resembles the corresponding human Nail-Patella Syndrome (NPS) (Chen et al. 1998a). …
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The Role of PTF1A in Spinal Cord Development
… the dI4 dorsal interneurons trans-fate to dI5 (Lmx1b+), and the dILA to dILB (Lmx1b+;Tlx3+). This mis-specification of neurons results in a complete loss of inhibitory GABAergic neurons and an increase in the excitatory glutamatergic neurons in the dorsal horn of the spinal cord by E16.5. Thus, …
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Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
… used comparative genomics to predict potential Lmx1b core binding sites in the Emx2 gene. Both Lmxlb and <em>Emx2</em> are factors involved in forelimb and shoulder girdle dorsalization.</p>