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Showing 1 to 20 of 61 for “"Liver--Diseases"”.
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Salivary proteome investigation for Autoimmune Liver Diseases classification and biomarker discovery
Autoimmune Liver Diseases (AILDs) are pathologies afflicting the liver caused by an inappropriate immune response against self-antigens and bringing, if not properly managed, to hepatic damage, chronic inflammation, and systemic repercussions. Despite progress in understanding the etiopathogenesis, …
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Low-dose imaging of liver diseases through neutron stimulated emission computed tomography: Simulations in GEANT4
… between benign and malignant tissue and diagnose liver iron overload while using a neutron beam tomographic acquisition protocol followed by iterative image reconstruction. These studies have shown that moderate concentrations of iron can be detected in the liver with moderate dose levels and long …
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Molecular and systems-level analyses reveal the emerging role of non-coding RNAs in liver diseases
The liver is the largest solid organ in the human body, and functions to detoxify various chemicals, metabolize nutrients, and support almost every organ in the body. Thus, the liver is prone to many diseases. Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, is an umbrella …
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Clinical, Diagnostic, Therapeutic and Prognostic Aspects of Autoimmune Liver Diseases /// Клинико-диагностични, терапевтични и прогностични аспекти на автоимунните чернодробни болести
Темата на дисертацията е свързана със сравнително редките автоимунни болести на черния дроб – автоимунен хепатит (АИХ), първичен билиарен холангит (ПБХ), първичен склерозиращ холангит и наслагващи се синдроми. За първи път у нас е извършена цялостна характеристика на автоимунните чернодробни …
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Meta-analysis of liver transcriptomic data identifies accurate disease classifiers and disease perturbed networks
Chronic liver diseases are a major health problem. Previous DNA microarray studies of different liver diseases have improved our knowledge of the molecular pathogenesis of liver diseases and produced potential biomarkers. However, these studies typically rely on binary phenotype comparisons (e.g. …
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Outcome and Resource Use of Patients with Liver Disease: Analysis of Chinese Electronic Medical Records
… care quality, such as the outcome studies of liver diseases, require large databases and rich case mix information to incorporate severity assessment and risk adjustment in order to generate robust results. Researchers worldwide have recognized the potential value of electronic medical record …
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Machine learning and data analytics for liver disease modeling
… (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain …
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Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, …
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Advancement of 31P Magnetic Resonance Spectroscopy Using GRAPPA Reconstruction on a 3D Volume
… treatment response to radiation therapy in liver cancer. Liver metabolism correlates with inflammatory and neoplastic liver diseases, which alter the intracellular concentration of phosphorus- 31 (31P) metabolites [1]. It is assumed that such metabolic changes occur prior to physical changes …
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The liver in disease: with special reference to aspiration liver biopsy
… biochemical methods used in the study of liver diseases with the histological appearance of the liver. The liver in acute hepatitis and obstructive jaundice is described in some detail, and next come reports of various cases in which the method has been applied either diagnostically or for …
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
Liver fibrosis is the result of different types of chronic liver diseases, such as cholestatic liver disease and nonalcoholic steatohepatitis, among others. Fibrosis, if left unchecked, may progress to the point of cirrhosis – permanently affecting liver function detrimentally and potentially …
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Διασπορά της ηπατίτιδας Β (ΗΒ) κατά την οδοντιατρική πράξη
… at the Athens Hospital for Infectious Diseases. From September 1982 to September 1984 three hundred and thirty one {22%) of the 1,504 patients had a history of dental treatment during the six months prior to the acute illness. Of the 331 patients, 207 were treated by 200 dentists in the …
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
… significant advances in our knowledge about liver pathology and regeneration, non-palliative regimens for most end-stage liver disorders are limited. The only definitive treatment for end-stage liver failure is an orthotopic liver transplant. Unlike other major causes of mortality, death …
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Using Telemedicine To Optimize The Delivery Of Care In Patients With Liver Disease
<p>Chronic Liver Disease (CLD) is one of the top causes of morbidity and mortality globally. Among the spectrum of liver diseases, non-alcoholic steatohepatitis (NASH) is the most common cause of cirrhosis and one of the top reasons for a liver transplant. Patients with NASH end up with hepatic …
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AAV9-mediated (Pro)renin Receptor Antagonism Reduces High Fat Diet Induced Hyperglycemia and Hepatic Steatosis in Mouse Model of Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of liver diseases worldwide. It has been associated with impaired metabolism and increased accumulation of triglyceride (TG) in the liver, most of which is derived from exogenous sources including diet. Recent studies showed …
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Biological and Biomechanical Effects of Direct Perturbation of Tissue Structure in the Cirrhotic Liver
… that occurs as the common final stage of chronic liver diseases. Although our understanding of the disease has improved substantially over the past several decades, there has been little progress in the treatment of cirrhosis. Drug development has been unsuccessful largely because it is difficult …
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MAdCAM-1 expression and function in human liver
… Recent studies have reported its expression in liver diseases such as primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) that complicate IBD, therefore understanding the factors that drive hepatic expression of MAdCAM-1 might elucidate the pathogenesis of these diseases. In …
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Mass spectrometry-based protein profiling strategies for biomarker discovery in liver and inflammatory bowel diseases
… strategies have been developed and applied to liver and inflammatory bowel diseases (IBDs) for the discovery of new biomarkers. The first of them, based on bulk solid-phase extraction combined with matrix-assisted laser desorption/ionization - Time of Flight mass spectrometry (MALDI-TOF MS) and …
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