Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Liver toxicity"”.
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
… however, has been hampered by dose-limiting liver toxicity. Lack of knowledge of the mechanisms underlying this toxicity has limited the potential to separate 4-1BB agonist driven tumor immunity from hepatotoxicity. The capacity of 4-1BB agonist antibodies to induce liver toxicity was …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
… dysfunction, particularly its role in liver toxicity. Complex I inhibition causes an energy deficit and can lead to adverse changes in the status of the mitochondrial [NADH]/[NAD+] pool and increased reactive oxygen species production, causing widespread damage. A library of molecules …
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Developing in vitro models to elucidate the mechanisms of toxicity of locked nucleic acid gapmer antisense oligonucleotides.
… also shown various toxicities, including hepatotoxicity. Mechanisms of ASO-induced toxicity are still not fully understood, but ASO-protein interactions have been shown to play a vital role in the tolerability of ASOs. This study investigated the safety of antisense oligonucleotides by …
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An ethical assessment of the adoption of pre-exposure prophylaxis as a potential HIV prevention method in Zambia
… percent mentioned kidney failure and 31 percent liver toxicity as side effects. The study has shown that 50 percent cited high cost of implementation as a concern. The study also shows that 60 percent preferred early adoption of Pre-exposure Prophylaxis. On the other hand 31 percent cited …
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An ethical assessment of the adoption of pre-exposure prophylaxis as a potential HIV prevention method in Zambia
… percent mentioned kidney failure and 31 percent liver toxicity as side effects. The study has shown that 50 percent cited high cost of implementation as a concern. The study also shows that 60 percent preferred early adoption of Pre-exposure Prophylaxis. On the other hand 31 percent cited …
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Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis
The liver is responsible for lipid and glucose metabolism, protein and bile synthesis and the biotransformation of xenobiotics. These functions, performed by hepatocytes, are dependent on heterotypic interactions with other liver cell types and the stratified microarchitecture of the organ. In …
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Modulating macrophage phenotype for obesity therapy
… effects, like gastrointestinal distress and liver toxicity, which limit their potential for long-term use. Off-target effects occur because the targets of these drugs exist in diverse cell types throughout the body. For this reason, there is a need to deliver these drugs solely to macrophages …
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Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
… (ELEM), porcine pulmonary edema (PPE), liver toxicity in several animals and esophageal and liver cancer in humans. In one of our studies we hypothesize that aqueous extracts of indigenous South African wild garlic species (Tulbaghia violacea, T. alliacea and T. simmleri) may enhance the …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also investigated. First, the miRNA signature of DILI induced by paracetamol was …
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Development of Knowledge Within a Chemical-Toxicological Database to Formulate Novel Computational Approaches for Predicting Repeated Dose Toxicity of Cosmetics-Related Compounds
… Models for the Prediction of Human Repeated Dose Toxicity of COSMetics to Optimise Safety) project was initiated as one of the seven consortia of the cluster, with the purpose of facilitating the prediction of human repeated dose toxicity associated with exposure to cosmetics-related compounds …
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Establishing species-specific 3D liver microtissues for repeat dose toxicology and advancing in vitro to in vivo translation through computational modelling
… 21% of drug attrition attributed to toxicity during the development process [3]. The in vivo/ex vivo use of animals in science, and in particular drug development, is a global practice and the main purposes of animal experiments are; (i) to gain basic biological knowledge, (ii) for …
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Analysis of DNA damage and repair responses in cerium exposed cells and hepatocyte spheroids
… predictive 3D models would be beneficial is liver toxicity studies, since hepatocytes have been shown to have improved levels of liver specific metabolic activity in 3D culture. While many complex platforms have been developed for this purpose, a very simple and effective approach is to …
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Engineering kinetics of immunotherapies and vaccines
… with respect to improved efficacy and decreased toxicity; all without necessitating the approval of new agents. In this thesis, we explored two distinct strategies to engineer immunotherapy and vaccine kinetics. We show how these kinetics can significantly impact cellular and humoral immune …
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In vivo Examination of Peripheral Drivers of Alzheimer’s Disease
… pathology in mice with history of either liver injury or sepsis. In the former subjects, we found that even in the absence of genetic risk factors for AD, elderly mice submitted to recurrent hepatotoxicity since an adult age display memory impairment congruent with persistent, but not …
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Analysis of Virtual Control Groups and Inter-species Concordance using Preclinical Toxicity Data
… 1 (Introduction). In line with the US EPA’s “Toxicity Testing in the 21st Century: A Vision and Strategy” and the Replacement, Refinement, and Reduction (3Rs) goals for animals in toxicity testing, the current two species preclinical testing paradigm for small molecules outlined in ICH M3 (R2) …