Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Liver steatosis"”.
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Development of Knowledge Within a Chemical-Toxicological Database to Formulate Novel Computational Approaches for Predicting Repeated Dose Toxicity of Cosmetics-Related Compounds
… of this database enabled the development of liver toxicity ontology, followed by mechanistic mining of in vivo data (chapter 7). As a result, compounds associated with liver steatosis, steatohepatitis and fibrosis phenotypic effects were identified and further analysed. The probable …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
The term non-alcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. End-stage NAFLD cirrhosis carries a substantial risk for early hepatocellular carcinoma development. Therefore, there …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… linked to disease including non-alcoholic fatty liver disease (NAFLD). Trimethylamine N-oxide (TMAO) and phenylacetic acid (PAA) are microbiome-derived metabolites that have been associated with early onset of NAFLD. Hypothesising that these metabolites contribute to lipid deposition in the liver …
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Dipeptidyl Peptidase-4 in Cariometabolic Disease
… of metabolic dysfunction-associated steatotic liver disease (MASLD), cardiometabolic disease and myocardial infarction. In vivo experiments were conducted using several genetic models, including systemic Dpp4 knockout mice (Dpp4-/-), hepatocyte-specific knockout mice (Dpp4hep-/-) and …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
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Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… resistance, hypertension, dyslipidemia, and liver steatosis. The incidence of metabolic syndrome and the accompanying risk of developing cardiovascular disease and type II diabetes is dramatically increasing. Disrupted homeostasis of metabolites contributes to metabolic disease. Farnesoid X …
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SARCOPENIA, LIVER AND CARDIOVASCULAR ALTERATIONS IN A MULTICENTRIC COHORT OF PATIENTS WITH MASLD: EVALUATION OF CLINICAL PRESENTATION AND GENETIC PREDISPOSITION
… with several diseases, including chronic liver disease (CLD) and cardiovascular (CV) disease. Metabolic-dysfunction associated steatotic liver disease (MASLD) is defined by the presence of liver steatosis combined with, at least, one cardiometabolic risk factor, with liver fibrosis serving …
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NON-INVASIVE METHODS TO PREDICT AND MONITORING METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE BY USING ULTRASOUND IMAGING
Metabolic-Associated Steatotic Liver Disease (MASLD) is becoming increasingly critical due to its rising global prevalence and its potential to progress to more severe liver diseases, such as Metabolic-Associated Steatohepatitis (MASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The …
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Cooperation between peroxisome proliferator activated receptor alpha and delta in regulation of body weight and hepatic steatosis in mice
… PPARd-agonism can stimulate fat accumulation in liver, which may aggravate the toxic situation in diabetics. <br/>The aim of the study was to characterise the hepatic transcriptional and lipid response of humanized mouse models to PPARd-agonists. <br/>In our studies of mice …