Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Liver signaling"”.
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… processes, TCA cycle intermediates may serve as signaling molecules. The TCA cycle intermediates succinate and α-ketoglutarate are specific natural ligands for previously orphan receptors GPR91 (Sucnr1) and GPR99 (Oxgr1), respectively. The function of Sucnr1 is more extensively studied and its …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… the terminal ileum and transported back to the liver via the portal circulation. Bile acids circulating in the enterohepatic circulation play important roles in maintaining bile acid, lipid and glucose homeostasis and inflammatory response. Disruption of bile acid homeostasis could contribute to …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… modulated in response to endotoxin and cytokine signaling. This work assesses the role of NF-κB and PXR in the transcriptional regulation of hepatic transporters and elucidate the signaling pathways behind changes in transporter expression. We hypothesized that the regulatory mechanism of hepatic …