Global ETD Search
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Showing 1 to 12 of 12 for “"Liver resection"”.
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Analysis of factors influencing early outcome following liver resection
… post-operative morbidity and mortality following liver resection. A secondary aim was to analyse the outcome of liver resection for colorectal liver metastases (CRLM) to identify factors associated with tumour recurrence and survival. Methods A retrospective review of a prospectively maintained …
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Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre
… carcinoma (HCC) is the most common primary liver malignancy in adults and is the fifth most common solid tumour worldwide with a variable prevalence based on underlying risk factors and geography. The incidence has risen over the past several decades and HCC is now the third leading cause of …
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Perioperative Allogenic Red Blood Cell Transfusion: Available Guidance and Audit of Appropriateness in Liver Resection
… single centre revealed 19% of patients underging liver resection were transfused a mean of 2.6 units during the perioperative period. A total of 22% to 63% of transfusions administered during the intraoperative period were considered inappropriate based on the application of three different …
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The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure
Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have …
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Trends and Comparative Effectiveness in Treatment of Stage IV Colorectal Adenocarcinoma
… modalities include systemic chemotherapy, resection of the primary tumor, and, in select cases, resection of metastatic disease. Historically, stage IV disease was first managed with surgical resection to prevent complications such as obstruction, bleeding, and perforation prior to starting …
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Improving Treatment of Local Liver Ablation Therapy With Deep Learning and Biomechanical Modeling
… cancer, and 60-70% of patients will develop liver metastasis. While surgical liver resection of metastasis is the standard of care for treatment with curative intent, it is only avai lable to about 20% of patients. For patients who are not surgical candidates, local percutaneous ablation …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… in hepatocytes was investigated in terms of liver regeneration, liver dependent iron homeostasis and gram positive sepsis. Therefore, mice either defective in hepatocyte-specific gp130-dependent Ras/Erk or STAT activation were generated to define the role of these signalling pathways. These …
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The Use of Synthetic Platelets to Augment Hemostasis
… Determine their efficacy in a lethal hemorrhagic liver injury model, 2) determine the impact of targeting ligand concentration on hemostasis, and 3) test them in a clinically relevant porcine model of hemorrhage.Nanoparticle administration (GRGDS-NP1, 40 mg/kg) after lethal liver resection in the …
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Engineering Materials for Non-Compressible Torso Hemorrhage and Internal Bleeding
… interact with wound-specific components when delivered intravenously to enhance preexisting hemostatic processes. The first part of this thesis investigates the effect of hemostatic nanoparticle size on their interactions with platelets. Small nanoparticles were observed to result in an …
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
Rates of primary liver cancer are increasing in the Western world, a fact yet to be reflected in research with most currently undertaken in Asia. Whilst here in the UK, during a diagnostic and therapeutic workup within the NHS, surgically resected tumours are routinely kept in storage for up to …
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The Characteristics of Right Hepatic Vein in Middle Hepatic Vein Dominant Type, and the Variation of Glissonian Pedicle at Left Lobe of the Liver, Using Cadaver Liver Dissection
Introduction: Many liver resection and liver transplantation surgeries are performed worldwide, and clinical outcomes have recently improved. Studies of liver anatomy have developed alongside clinical and technical achievements as these types of research complement each other. I intended to …
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Fatores prognósticos na ressecção de metástases hepáticas de câncer colorretal
OBJETIVO: Determinar o impacto de fatores prognósticos na sobrevida de pacientes com metástases hepáticas ressecadas e originadas de câncer colorretal. CASUISTICA E MÉTODOS: Foram analisados os prontuários de 28 pacientes submetidos a ressecção hepática de metástases de câncer colorretal de Abril …