Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Liver progenitor"”.
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
… to examine different processes within the liver. One system was designed to examine liver progenitor development and integrate tunable factors that can be used to change the differentiation trajectory of these progenitors in a 3D aggregate. We found them to be very susceptible to the growth …
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Investigating the role of geometry, mechanics, and microenvironmental cues on liver progenitor cell differentiation
… how mechanical characteristics impact liver progenitor cell differentiation. In this dissertation, I will introduce and review relevant concepts of mechanobiology and the 2D and 3D in vitro systems used doe measurement and manipulation. I then describe my work combining microarrays with …
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Establishing a joint 2D/3D high throughput approach for evaluation of the effects of Wnt signaling and microenvironemtnal cues on liver progenitor cell differentiation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… microenvironmental regulation in the context of liver progenitor differentiation and lung tumor cell drug responses. Liver progenitor differentiation was found to be combinatorially regulated by Notch, TGFβ signaling as well as interactions with ECM proteins. The Notch ligands Jag1 and Dll1 were …
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A THREE DIMENSIONAL MODEL OF HUMAN HEPATO-BILIARY ORGANOGENESIS
… have emerged aimed at generating functional liver tissue by using decellularized liver scaffolds repopulated with liver cells. The quest continues for identifying the best cell source for liver tissue engineering, but one cell source in particular, human fetal liver progenitor cells (hFLPCs), …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
It has been proposed that liver regeneration in chronic liver disease, such as metabolic dysfunction-associated steatotic liver disease, previously known as non-alcoholic fatty liver disease, is driven by hepatocyte renewal in the early stages, but when hepatocyte proliferation is impaired due to …