Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Liver macrophages"”.
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
The pathogenesis of inflammatory liver diseases and development of liver fibrosis involves hepatocytes as well as non-parenchymal liver cells like resident liver macrophages (Kupffer cells (KC)), Stellate cells and endothelial cells. Kupffer cells play a critical role in liver (patho)physiology and …
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Defining Delivery Pathways of Nanoparticles
… reach the tumour. To address this delivery inefficiency, it is important to examine each biological barrier to determine its impact on delivery. In this thesis, first the body was modelled as a series of barriers that nanoparticles need to overcome successively in order to access the …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a liver cancer and is one of the leading causes of cancer death worldwide. Despite significant efforts in treating HCC, such as with the use of novel immune checkpoint inhibitors, the overall response rate remains low. This may be partly attributed to the lack of a …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
… which is characterized by iron deposition in liver macrophages and anemia. Aside from loss-of-function genetic mutations, FPN1 deficiency can be induced by inflammation. Therefore, iron misdistribution also underlies various diseases associated with chronic inflammation, such as rheumatoid …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether macrophage subset …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… leading to acute thrombocytopenia in liver xenotransplantation. Mechanisms for xenogeneic thrombocytopenia were evaluated using liver macrophages, Kupffer cells, leading to identification of CD18, beta-2 integrin, as a potential target for modification. When disruption of CD18 was …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… of an immune response. </p> <p>To induce acute liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When these animals were pretreated with MSO, 80% of the animals were completely rescued from liver …
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Insulin resistance in cancer cachexia and metabolic syndrome
… inflammation. In these scenarios, tissue macrophages act as key players, due to their capacity to produce and release inflammatory mediators. One of the main features of MetS is hyperinsulinemia, which is generally associated with an attempt of the β-cell to compensate for diminished …