Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Liver inflammation"”.
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
Liver fibrosis is the result of different types of chronic liver diseases, such as cholestatic liver disease and nonalcoholic steatohepatitis, among others. Fibrosis, if left unchecked, may progress to the point of cirrhosis – permanently affecting liver function detrimentally and potentially …
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Utilization of TMV-TEMPO as an in Vivo MRI Sensor of ROS Production in Liver Inflammation and as a DNP Agent
… reactive oxygen species (ROS) in murine model of liver inflammation and ii) its feasibility as an agent in MRI signal-enhancing dynamic nuclear polarization (DNP) technology. Chapter 1 entails discussion of the basics of magnetic resonance and hyperpolarization. Chapter 2 involves discussion of …
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Β-carotene promotes atherosclerosis resolution and alleviates liver inflammation in a reversible murine model of atherosclerosis: A potential role of regulatory T cells
… on atherosclerosis regression and hepatic inflammation. Methods: We utilized various animal models to study atherosclerosis regression: In our first model, we used weekly injections of an antisense oligonucleotide targeting the expression of the low-density lipoprotein receptor (LDLR ASO). …
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Role of monocyte subsets in chronic liver injury and liver fibrosis
… immune system and crucially modulate tissue inflammation after injury. Mammalian monocytes consist of two principle subsets that display different chemokine receptor expression levels. In humans, the classical monocyte CD14++CD16- subset expresses CCR2, CD64, CD62L and low levels of the …
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Deciphering the relationship among nutrition, host and microbe
… linked diseases including non-alcoholic fatty liver disease (NAFLD), inflammatory bowel disease (IBD) and colorectal cancer (CRC). The consequences of the changing microbiota in these disease states and how the microbiota can be used therapeutically has yet to be fully explored. In this body of …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
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Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection
… of CHB and predict the state of significant inflammation in patients with CHB. METHODS: A total of 339 CHB patients who underwent liver biopsy, were included. Serum M30 antigen levels were compared with inactive carriers (n=36), patients with HBeAg- negative hepatitis (n=80), HBeAg-positive …
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Epigenetic toxicity of PFOA in HepG2 cells and its role in lipid metabolism
… damage over time with unusual fat deposit and liver enlargement. To closely study the underlying mechanisms of PFOA induced hepatocellular damage. Liver hepatocellular carcinoma cell line HepG2 was used as a model to study the PFOA induced inflammation in vitro on the cellular, epigenetic and …
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Constraints on the CD8 T cell response in chronic HBV infection
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… and alkaline phosphatase activities, reduced liver inflammation and fibrosis, and normalized copper levels in brain and urine. TFEB and TRPML1 overexpression also increased biliary copper excretion, suggesting enhanced lysosomal exocytosis at the canalicular domain of hepatocyte plasma …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
… source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- and IL-22-producing cells in mouse liver during viral infection. We found that a subset of IL-17+ and IL-22+ cells expressed no …
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THE ROLE OF CGI-58/ABHD5 IN LIPID METABOLISM, INFLAMMATION, AND INSULIN ACTION
… can accumulate to harmful levels and lead to inflammation and metabolic diseases like fatty liver and diabetes. In 2001, a novel protein known as Comparative Gene Identification 58 (CGI-58) was discovered to regulate cellular levels of triglyceride, a major lipid storage molecule. Humans with …
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All- trans-retinol modulation of chemically-induced pulmonary and hepatic toxicity
… injury of compounds that cause both liver and lung toxicity is unknown. Therefore, the studies presented here were designed to test the hypothesis that: all-trans-retinol increases hepatic injury through a pro-inflammatory mechanism, whereas in the lung injury is attenuated through an …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
… is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous research has largely focused on the contribution of virus-specific T cells to this …
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Nutritional and environmental stressors and their effects on performance, metabolism, and the immune system of dairy cattle
… in POS had greater MUN and BUN than cows in MM. Liver concentrations of Se and Fe were greater for cows in MM compared to cows in POS. An upregulation of liver GPX1 was observed for cows in POS compared to cows in MM. In the second experiment, 16 multiparous, lactating, Holstein cows were …
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On Leukocyte Recruitment in Cholestatic Liver Injury
… of the biliary tract. This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment has emerged as a key feature. Therefore, the aim of this thesis was to analyze the detailed mechanisms behind intrahepatic …