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Showing 1 to 16 of 16 for “"Liver fibrogenesis"”.
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… of the common bile duct was used to induce liver fibrosis in rats. Animals received injections of an adenovirus overexpressing Smad7. The effect of Smad7 on TGF-beta signaling and activation of HSC was further analyzed in primary cultured cells. AdSmad7 infected rats displayed reduced …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
Production of fibrous scar tissue in the liver is a normal response to injuries. In fibrosis this healing process is disturbed. Liver fibrosis is defined as the accumulation this fibrous scar tissue in the liver. After hepatocyte damage due to e.g. viral infection, heavy alcohol consumption, toxins …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… that cyclin E1-/- deletion results in normal liver regeneration with slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression of cyclin E1 and prolonged cdk2 kinase activity leading to earlier and sustained DNA …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… crucial role in the wound healing process of the liver and is, thus, linked to the development of fibrosis. Endoglin functions as a TGF-beta receptor and TGF-beta, on the other hand, is a key regulator that initiates and perpetuates the transdifferentiation process. This raises the questions …
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
The pathogenesis of inflammatory liver diseases and development of liver fibrosis involves hepatocytes as well as non-parenchymal liver cells like resident liver macrophages (Kupffer cells (KC)), Stellate cells and endothelial cells. Kupffer cells play a critical role in liver (patho)physiology and …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) leads to the reversal of the accumulated extracellular matrix. We therefore hypothesize that targeted …
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Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… ligands can be used for diagnosis and therapy of liver fibrosis. The mechanism of fibrogenesis and potential treatments of liver fibrosis are summarized in Chapters 1 and 2. In Chapter 3, we identified HSC-specific peptides using a peptide phage display for diagnosis and treatment of liver …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… dissertation is to develop peptide-based siRNA delivery systems for the treatment of liver fibrosis and pancreatic ductal adenocarcinoma (PDAC). We recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) gene in hepatic stellate cells (HSCs) and NIH 3T3 fibroblasts can reverse …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
Liver cirrhosis is characterized by hepatic dysfunction with extensive accumulation of fibrous tissue in the liver. Even though the number of hepatocytes seems to be enough to maintain liver function, hepatic failure is one of the main causes of death in the patients with liver cirrhosis. The role …
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Etablierung adenoviraler Genexpression zum antifibrotischen Einsatz bei der Leberfibrose
Liver fibrosis results from an imbalance between synthesis and degradation of extracellular matrix components due to a variety of deseases such as virus hepatitis, alcoholic abuse or metabolic dysfunction. The cytokine TGF-ß plays an important role in so far it interferes during hepatic injury with …
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Kryokonservierung von hepatischen Sternzellen der Ratte
… Isolated HSC of the rat are used as a model of liver fibrogenesis. Many proceedings are studied on this cells, for example the biotransformation, the gene expression, the effect of pharmaceuticals, different kinds of transcriptional factors and many more. Methods for the isolation of rat hepatic …
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Induzierter Zelltod von transdifferenzierten hepatischen Sternzellen (Myofibroblasten) auf der Basis des Thymidinkinase-Ganciclovir-Systems
… used to develop a prophylaxis in oder to prevent liver fibrogenesis. The intention was to eliminate activated hepatic stellate cells (HSC), those cells which became proliferative, fibrogenetic and contractile because of liver injury. Activated HSC are called myofibroblasts. They are mainly …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH is characterized by steatosis, inflammation, cell death, and liver fibrosis and significantly increases the risk of …
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Untersuchungen zur TGF-[beta]1-Expression und -Bioverfügbarkeit bei der Leberfibrogenese
… is one of the most important cytokines mediating fibrogenesis in the liver and in other organs. The major portion of it is secreted as latent molecule complexed either only with the “latency associated peptide” (LAP) or with LAP and the “latent TGF-Beta binding protein” (LTBP). Activated hepatic …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… the interaction between BMP-7 and TGF-b1 within liver fibrogenesis hepatic stellate cells, as one of the most important cellular modulators of fibrosis were analyzed. In hepatic stellate cells the TGF-b signal is translocated via ALK1 and ALK5 such as already mentioned for L6E9, resulting in …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
Hepatische Sternzellen (HSC) und Lebermyofibroblasten (LMF) sind maßgeblich an der Leberfibrogenese beteiligt. Untersuchungen der letzten Jahre weisen darauf hin, dass HSC - im Gegensatz zu LMF - parallel mit ihrer Aktivierung der spontanen Apoptose unterliegen. LMF sind daher von zentraler …