Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Liver cancer"”.
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Biomimetic and vascularized 3-d liver cancer model
… in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell viability, contradicting clinical trials. In vitro models should mimic clinical trials in order to accurately predict drug outcomes. 2D in vitro models fail because they …
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Genomic Profiling of Alternative splicing in liver cancer
The development of liver cancers is a multistep process, which is known to progress through diverse molecular and biological mechanisms. Recently, the next generation sequencing has allowed many advances in the characterization and quantification of transcripts in genome-wide manner. In particular, …
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Structural evolution of lipid droplets in murine liver cancer
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Role of retinoblastoma protein in the development of liver cancer
Hepatocellular carcinoma is the sixth most common cancer worldwide with a diverse aetiology. Dysregulation of the Rb pathway can occur in as high as 92% of liver cancers implicating Rb as an important factor in the progression of the disease. The impact Rb loss has on the development of liver …
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Physical activity counseling and programming preferences of liver cancer survivors
Background: Liver cancer is the second leading cause of cancer deaths worldwide and is comorbid with diseases associated with physical activity (PA) such as obesity, cirrhosis and non-alcoholic fatty-liver disease. Although PA has shown to have a positive effect on physical, psychological, and …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… but absent in hepatocytes in the healthy liver. Remarkably, its expression is robustly switched on in transformed hepatocytes in two liver cancer models induced by DEN and overexpression of Neu respectively. Moreover, germline whole-body knockout of TSPAN8 significantly suppresses the …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
Liver cancer is one of the leading causes of deaths in many countries around the world therefore identifying new risk factors for liver cancer is a priority. The aim of this thesis was to investigate new risk factors for liver cancer and add new insights to previously identified liver cancer risk …
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Regulation of Senescence Phenotypes by TIS21 gene in Huh7 Human Liver Cancer Cells
… 암세포의 세포노화환경을 만들고자 사용한 Doxorubicin은 대표적인 anti-cancer drug로서 DNA 염기서열에 직접적으로 삽입되어 α-helix구조의 변형을 초래하여 DNA damage를 일으킨다고 알려져 있다. Doxorubicin은 농도에 따라 세포노화를 일으키거나 세포사멸을 일으킬 수 있다. 저농도의 Doxorubicin은 세포노화를 유도할 수 있지만 Doxorubicin에 의해 유도되는 노화기전은 아직 정확히 규명되지 않았다. 본 연구에서 간암세포주인 Huh7 에 저농도의 doxorubicin을 …
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A Study of The Snd1/Prmt5 Axis In Liver Cancer By Genetic Mouse Models
… PRMT5 has been reported as upregulated in many cancers and may predispose hepatocytes to develop HCC. However, it remains to be determined if <em>Prmt5 </em>overexpression (OE) alone is sufficient to drive HCC. This work utilizes three new GEMMs, namely a <em>Snd1 KO</em>, <em>Snd1 </em>Tudor …
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Substrate Identification of an Oncogenic Kinase: Elucidating the Pathogenesis of a Rare Liver Cancer
… Hepatocellular Carcinoma (FLC) is a rare liver cancer with limited treatment options. This cancer primarily affects adolescents and young adults. Our lab has identified a new fusion gene in this cancer called DNAJB1-PRKACA that results from a break and re-fusion in chromosome 19. This …
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Targeting iNAMPT to Break the Obesity-Associated Liver Cancer Link: An In Vitro and In Vivo Approach
… Studies have shown that obesity is linked to liver cancer through metabolic mechanisms. Obesity can promote tumor growth through metabolic impairment, decreased lipid metabolism, and the interference of energy balance in the liver. NAMPT is an enzyme expressed in the liver and is involved in …
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The Efficacy of Immunotherapy in Preventing Liver Cancer and the Role of Metabolic Zonation in Its Development
… to study the development and progression of liver cancer, as well as the efficacy of novel therapeutic strategies, accurate models of human disease are needed. In particular, in vivo mouse models capture critical characteristics that are relevant to human hepatocellular carcinoma (HCC). There …
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Poly(Arginine) Derived Cancer-Targeting Peptides for the Development of a Cancer-Targeted Gene Therapy Approach in HepG2 Liver Cancer Cells
<p>Cancer is a disease that has eluded medicinal approaches for many years and as a result new and improved therapeutic approaches are in constant demand. Although chemotherapy and radiation treatments have assisted in suppressing the growth of tumors, their poor selectivity and efficacy are major …
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High Frequency Irreversible Electroporation (H-FIRE) as a Therapeutic Modality for Liver Cancer Treatment and Its Effect on the systemic Extracellular Vesicle Population
… electrical pulses to induce cell death in cancerous tissues. It's being studied for treating hepatocellular carcinoma (HCC) in dogs. Previous in vitro research suggests H-FIRE may impact the release of extracellular vesicles (EVs). This study aims to explore how H-FIRE affects peripheral …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
Primary liver cancer (PLC) is the second most common cause of cancer death worldwide, preceded only by lung cancer. Current models for PLC either fail to fully recapitulate tumour histology and architecture or are expensive, time consuming and do not allow for personalised drug testing. During the …
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IDENTIFYING THE ROLE OF TIP60 IN HEPATOCELLULAR CARCINOMA
… which is the primary malignancy of the liver and accounts for high mortality rate. It was observed that TIP60, a tumor suppressor implicated in multiple cancers, is downregulated in cells expressing HBx, an oncogene of HBV. This was through a proteasomal mechanism such that HBx utilizes …
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Model-based cardiac CT segmentation and 3D heart reconstruction
Liver cancer is a serious disease in human beings. An effective way to cure liver cancer is the liver transplant operation. However, to make the surgical plan, the doctors need to know the structure, location and thickness of the hepatic vein. Therefore, hepatic vein segmentation is an initial and …
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