Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Liver X receptors"”.
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… regulatory element binding proteins (SREBPs) and liver X receptors (LXRs). This thesis describes the identification by microarray technology of novel genes in cholesterol metabolism and the characterization of two of these genes. Microarray analysis of the livers of mice fed a low versus high …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… targets: peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) which are key regulators of various processes leading to metabolic disorder and inflammation. As a part of inflammatory pathway, …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… upregulated metabolic dependence of cancer. The liver X receptors (LXR) are ligand-modulated nuclear receptors. LXR activation upregulates the expression of genes involved in altered metabolic pathways in cancer, including cholesterol transport, glucose, and lipid metabolism. Moreover, LXR …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… Regulatory Element Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein Response (UPR)/ER Stress Response. This thesis attempts to characterize the in vivo physiological role of novel downstream target genes of these transcription factors: StARD5 and ADAM11. This thesis …
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Germline Genetic Determination of Cancer Outcome
… robust benefit of pharmacologic activation of liver-X-receptors, a class of transcription factors inducing APOE expression. In contrast, APOE2 showed no treatment benefit, indicating that APOE genotype may serve as a biomarker for response to LXR-agonistic immunotherapy. Overall, our data …
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Characterization of the Functional Role of the Intracellular Cholesterol Transporter StARD4 in Knockout Mice, and Investigation of Epigenetic Modulation of ApoA-I Transcription
… by Sterol Regulatory Binding Proteins (SREBPs), Liver X Receptors (LXRs) and Unfolded Protein Response (UPR) or ER stress families of transcription factors. StARD4 is regulated by SREBPs and we have chosen to make a mouse knockout model to characterize its role in-vivo. StARD4, expressed …
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Oxysterol Signature as Putative Biomarker in Niemann-Pick Type C and Inflammatory Bowel Diseases
… pathway and the second is the activation of liver X receptors α and β (LXRα and LXRβ). The third action of oxysterols is the accelerated degradation of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), a key enzyme of cholesterol synthesis. The final pathway triggered by …