Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Liver Neoplasms"”.
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
Rates of primary liver cancer are increasing in the Western world, a fact yet to be reflected in research with most currently undertaken in Asia. Whilst here in the UK, during a diagnostic and therapeutic workup within the NHS, surgically resected tumours are routinely kept in storage for up to …
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The Functional Roles of the Lin28/let-7 Axis in Tissue Regeneration and Cancer
… let-7 in the context of tissue regeneration and liver cancer. Our first study led us to discover that Lin28 overexpression is both sufficient to initiate liver cancer and necessary for its maintenance and that its oncogenic effects are mediated in part through downregulating let-7 and …
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The Efficacy of Immunotherapy in Preventing Liver Cancer and the Role of Metabolic Zonation in Its Development
… to study the development and progression of liver cancer, as well as the efficacy of novel therapeutic strategies, accurate models of human disease are needed. In particular, in vivo mouse models capture critical characteristics that are relevant to human hepatocellular carcinoma (HCC). There …
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Quality of Life Is Associated with Survival in Patients with Cirrhosis and Hepatocellular Carcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… the most common intraocular tumor in adults and liver metastasis is the leading cause of death in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay …
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The Role of Polyploidy in the Liver and Its Implications for Cancer Therapy
The description of liver polyploidy dates back to the 1940s, but its functional roles are still largely unknown. Numerous observations and studies have suggested that liver polyploidy may participate in multiple biological processes, including regeneration, stress response, and cancer. However, …
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Effect of Fragmentation of Cancer Care on Treatment Use and Survival in Hepatocellular Carcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… Late sequela of GSD1a includes the formation of liver adenomas and carcinomas without obvious signs of liver injury or cirrhosis. Here we show that the oncogenic transcription factor c-Myc potentiates metabolic rewiring and drives lactic acidosis and hyperuricemia in a mouse model of GSD1a. Using …