Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Live vaccine strain"”.
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Identification and characterization of a novel capsule-like complex surface antigen of Francisella tularensis
… less than 10 organisms via aerosol of a type A strain having the ability to cause fatal infection. Over the last decade much research has been done on the pathogenesis of this unique intracellular bacterium and many different virulence factors have been identified. The goal of this dissertation …
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Unraveling the host innate immune response to a respiratory model of Brucella abortus
… bacteria that cause abortion and infertility in livestock and chronic disease in humans. The Centers for Disease Control and Prevention (CDC) categorizes them as class B pathogens due to their zoonotic potential. Currently, there are no efficacious Brucella vaccines for humans available. Very few …
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Site-Directed Mutagenesis in Francisella Tularensis by Allelic
… severity of illness, and lack of licensed vaccines, F. tularensis has long been considered a potential biological weapon and is now classified as a category A select agent by the National Institutes of Health and the Centers for Disease Control and Prevention. The investigation of the …
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The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5A: role in serum resistance and characterization of the genetic basis for expression
… mutant will be evaluated as a potential live vaccine strain for the control of swine pleuropneumonia.
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Investigations Into a Rationally Designed Modified Live Vaccine for Equine Strangles
… disease is the lack of a safe and efficacious vaccine. The production of a safe and efficacious vaccine has been difficult. Currently available modified live vaccines lack safety and, to date, subunit vaccines have been ineffective in preventing experimental challenge. The goal of this work is …
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Surface Polysaccharides of Francisella tularensis: Further Characterization, Role in Virulence, and Application to Novel Vaccine Strategies
… bioweapon potential of these subspecies. Type A strains, considered the more virulent of the subspecies, are highly infective producing respiratory tularemia with inhalation of as few as 10 cells. Due to classification as a Select Agent, a vast amount of F. tularensis research has occurred in the …
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Mechanisms Involved in Enhanced Protection Against Gram Negative Bacterium Francisella tularensis Utilizing an FcR Targeted Vaccine Platform
… and research has failed to develop an effective vaccine. Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including F. tularensis, utilize the …