Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Live microscopy"”.
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Biophysical properties of blood-stage Plasmodium falciparum malaria: from single-cell host-pathogen interactions to human protective polymorphisms
… firstly includes the optimisation of a real-time live microscopy platform for recording parasite egress-invasion sequences under controlled conditions, and to investigate their morphology and kinetics. This set-up was employed to address the role of calcium in mediating successful invasion by …
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Structural and Spatiotemporal Organisation of Bax and Apaf1 during Apoptosis
… using a combination of biochemical and microscopy approaches. I sought to better understand the contribution of spatial and structural protein organisation within cells towards the efficient promotion of apoptosis, an essential cellular pathway. During apoptosis, Bax oligomerises on the …
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The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… imaging device allows for higher throughput live-imaging of cell lines to aid in the understanding of the relationships between intratumoral heterogeneity, invasion dynamics, and interstitial flow.
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Determining Molecular Mechanisms of Cell Division in Fission Yeast by Testing Major Assumptions of the Search, Capture, Pull, and Release Model of Contractile-Ring Assembly
… are captured by myosin-II in neighboring nodes. Live microscopy shows that Cdc12 localizes to a broad band of 30 to 50 dynamic nodes, where actin filaments are nucleated in random directions. Consistent with the SCPR model, myosin motor activity is required to condense the nodes into a …
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
… in this thesis begins by using real-time live microscopy to characterise the morphology and RBC invasion kinetics of *P. knowlesi*, and compare it to the more widely studied *P. falciparum*. Wild-type *P. knowlesi* was shown to have similar pre-invasion timings to *P. falciparum* in human …
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Cytotoxic T lymphocyte biology under the microscope
… biology. Throughout these different projects, microscopy has played an important part. Seeing really is believing, and the versatility of microscopic approaches is hopefully on full display throughout this thesis. High resolution live microscopy of individual CTL:target conjugates is perhaps …