Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Live attenuated vaccine"”.
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Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
… that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations that either restore the wild-type phenotype via reversion or compensate for the attenuating mutations by increasing virulence (pseudoreversion). …
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Development and Evaluation of Selected Chemoprophylaxis Candidates and a Candidate Live-Attenuated Vaccine for Prevention of Histomoniasis in Turkeys
… candidates as well as an in vitro live-attenuated vaccine candidate Histomonas meleagridis for prevention of histomoniasis. Chapter one addresses deoxycholic acid and a biliogenic diet intended to endogenously increase production of this secondary bile acid. Deoxycholic acid was …
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Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease: Characterization of a potential live-attenuated vaccine candidate
There is no FDA-approved vaccine against Yersinia pestis, the causative agent of bubonic and pneumonic plague. Since both humoral- and cell- mediated immunity are essential in providing protection to the host against plague, we developed a live-attenuated vaccine strain by deleting Braun …
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Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
… the Yucatan Peninsula. Almost 300 years later, a live-attenuated vaccine against yellow fever virus, the causative agent of yellow fever, was successfully derived by serial passage of Asibi virus 176 times in chick and mouse embryo tissue. The resulting vaccine strain, 17D, gave rise to all …
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Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens
… in Nicotiana benthamiana plants as potential vaccines against IBV. Modifying the full-length IBV Spike (S) protein resulted in high levels of VLPs resembling native IBV particles visualised under transmission electron microscopy. The highest VLP expression levels were obtained when the native …
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Induction of Long-Term Immune Responses to Protect Mice against Pneumonic Plague: Development and Testing of Novel Live-Attenuated Mutants of Yersinia pestis CO92
Currently, there is no FDA-approved vaccine against the causative agent of the pneumonic plague, Yersinia pestis. Since both humoral and cell-mediated immunity are essential in providing protection against the plague, we developed three novel live-attenuated vaccine strains. These mutants were …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… during epidemics until the introduction of a vaccine that drastically reduced the incidence of the disease. This live-attenuated vaccine, Candid#1 (Can), contained many amino acid divergences from wild type JUNV that may contribute to the attenuation profile. Preliminary experiments identified …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
… causes brucellosis. B. abortus strain RB51 is a live, attenuated vaccine licensed for cattle. However, there is no available vaccine to prevent human brucellosis. Outer membrane vesicles have been tested as potential vaccines to prevent diseases caused by bacterial species. OMV are constantly …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… hosts. In mouse models, the mutants were attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; in contrast to the NS1 mutant, the knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust …
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Translating biomedical research data to knowledge through bioinformatics
… should accelerate the development of a new live attenuated vaccine for Venezuelan equine encephalitis virus. In addition to the NGS data mining and knowledge discovery, we developed a novel ensemble data analysis method to improve the predictive ability of classic bagging and AdaBoost …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… hosts. In mouse models, the mutants were attenuated, as evidenced by lower viremia, decreased weight loss, and no mortality; in contrast to the NS1 mutant, the knockout of E glycosylation did not significantly affect neurovirulence. Mice immunized with the E mutant virus developed a robust …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
… failure. The disease is prevented by a live attenuated vaccine (LAV), strain 17D, that was derived from serial passage of the wild type (WT) strain Asibi in chicken tissue. The mechanism of attenuation of 17D is incompletely understood. This dissertation investigates the contribution of …
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Immunological control of toxoplasma gondii infection
… and encephalitis. Currently there are no human vaccines available. The first major aim of this study was to test potential HLA restricted peptide vaccines, previously shown to be protective in HLA-transgenic mice, against oocyst infection. The ability of entrapment within non-ionic surfactant …
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The Impact of the Non-Structural Small Segment Gene on Host Immune Responses Against Rift Valley Fever Virus
… between, the mosquito vector species, livestock, and humans, infection spreads to humans causing a range of mild to severe clinical conditions. The severe health and economic impacts RVFV exerts on endemic regions demands the urgent development of effective preventive and therapeutic …
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Characterization of Candidate Mutations for Use in a Live Attenuated West Nile Virus Vaccine
… the United States and Europe, but no human WNV vaccines have been licensed. Studies of WNV vaccine candidates and of vaccines for related flaviviruses indicate that a live attenuated vaccine based on the full-length WNV genome will likely induce the most robust protective immune response …
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Dissociating Siv Env and Cd4: Consequenes for Virus and Host
… of cells infected. We tested iMac239-ΔD385 as a live attenuated vaccine against a pathogenic SIVsmE660, and while the number of animals in the study is too small to determine significance we observed a trend toward improved outcomes post challenge, potentially due to a synergistic interaction …
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Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
… infection. However, the currently available vaccines for PRRSV are generally considered as not very effective. One of the major obstacles for developing an effective modified live-attenuated vaccine (MLV) with broad protection is the delayed and insufficient immune responses mounted by PRRSV, …
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DENVax live attenuated chimeric dengue vaccine
… a headache and fever to even death. There is no vaccine to prevent infection by dengue viruses and the only current protection and prevention is mosquito control. The dengue viruses and the Aedes aegypti mosquito that carries them are spreading to more areas of the world and are therefore posing …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
… caused economically devastating outbreaks in livestock and severe disease in humans. In pregnant ewes, RVFV infection can cause abortions in up to 100% of animals and high mortality rates (up to 60%), and it can cause fetal abnormalities and a high rate of mortality in newborn lambs. …
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Investigating the production of a particulate plant-produced vaccine candidate against African horse sickness
… by Culicoides midges. Currently, a multivalent live attenuated vaccine is the only vaccine licensed for use in South Africa. However, it has the inherent risk of reverting to virulence as well as the possibility of genome segment reassortment between vaccine and outbreak strains. Additionally, …
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