Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Liquid chromatography with tandem mass spectrometry"”.
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Development of liquid chromatography with tandem mass spectrometry method for measurement of sepsis biomarkers
… faster results and detection of biomarker using mass spectrometry (MS) technique emerges as an appealing sepsis diagnostic tool. MS-based assay enables accurate measurement of biomarkers in serum and offers multiplexing capability. Measurements of biomarkers aid clinicians in their decision …
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The Role of Mitochondria in Oxygen Sensing of the Ductus Arteriosus and Fetal Pulmonary Arteries
… and PA (vasodilation) are unknown. With the transition from fetal (hypoxic) to neonatal (normoxic) life, a failure of the DA to constrict or the PA to dilate in response to oxygen can precipitate patent ductus arteriosus and persistent pulmonary hypertension of the newborn, …
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Advancing Ovarian Cancer Diagnostics: Discovering Potential Protein Biomarkers in Extracellular Vesicles
… are crucial to reducing the mortality associated with this disease. The goal of these studies was to uncover novel biomarkers associated with tumor-derived extracellular vesicles (EVs) to advance ovarian cancer diagnostics.In the work presented in this dissertation, I show that EVs from plasma and …
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The determination of β-endosulfan and endosulfan sulfate in human serum with dialkylphosphate metabolites as urinary markers using LC-MS/MS electrospray ionization
… phosphate. For both the bioanalytical methods, liquid-liquid extraction was used for sample preparation and high performance liquid chromatography with tandem mass spectrometry as detection method due to its high sensitivity and selectivity. Chromatographic separation for both bioanalytical …
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The Development and Validation of a Direct LC-MS/MS Assay for the Determination of Tenofovir-diphosphate in Dried Blood Spots for the Analysis of Clinical Samples
… polar compound and traditional reverse-phase chromatography has poor retention and separation capabilities when used to retain polar compounds, therefore alternative strategies were implemented. In this developed direct method, an anion exchange column was used along with a pH gradient, with …
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Characterization of human foreskin Langerhans cells
… LCs was also examined by single-cell sequencing with seq-well. Lastly, the differences in the proteome of the inner FS and the outer FS migrated epidermal cells were assessed using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Results: Langerhans cells were an average of 85% …
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Development and validation of selective and sensitive LC-MS/MS Methods for determination of para-aminosalicyclic acid and cycloserine/terizidone applicable to clinical studies for the treatment of tuberculosis
… extraction, followed by high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) detection. Rilmenidine was used as the internal standard (ISTD). Analyte mean extraction yields determined were ~100.3% (CV % = 3.3). The extraction procedure was followed by liquid …
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Removal of Perfluorooctane Sulfonate (PFOS) and Related Compounds From Industrial Effluents
… (¹⁹F NMR) spectroscopy and high performance liquid chromatography (HPLC) with suppressed conductivity detection were successfully developed to monitor the presence of PFAS in water samples. Chromatographic separation of C₄ to C₈ PFAS surfactants was achieved using a C₁₈ reversed-phase column …