Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"Liquid chromatography tandem mass spectrometry"”.
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Liquid Chromatography -- Tandem Mass Spectrometry Techniques for Drugs of Abuse as Applied to Bacterial and Forensic Toxicology
… To analyze and quantify these effects, a novel liquid chromatography triple quadrupole tandem mass spectrometry method was developed for diazepam, flunitrazepam, and metabolites in Reinforced Clostridial Medium. Reinforced Clostridial Medium is a complex matrix designed to provide the nutrients …
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Analysis of Illicit Drugs, Their Metabolites and Other Micropollutants in Water by Liquid Chromatography Tandem Mass Spectrometry
<p>The goal of this project is to develop liquid chromatography tandem mass spectrometry (LC/MS/MS) methods for the analysis of different, novel micropollutants in waste water and natural water. Micropollutants are compounds that can exert adverse environmental and human health effects at low …
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High performance liquid chromatography-tandem mass spectrometry of pharmaceuticals and personal care products in environmental and biological matrices
… of these compounds at very low concentrations, liquid chromatography-tandem mass spectrometry (LCMS/ MS) has emerged as the new technique of choice. This work describes methods for screening and quantification of various pharmaceutical and illicit drug residues in solid and liquid environmental …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… assay approaches are being explored in research. Liquid Chromatography Mass Spectrometry (LC-MS/MS) methods are becoming an alternative approach and analytical technique combines the physical separation abilities of liquid chromatography with specific mass analysis of mass spectrometry. The …
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The Use of Liquid Chromatography Tandem Mass Spectrometry to Improve Newborn Screening for Congenital Adrenal Hyperplasia in New Zealand
… a second-tier steroid profile test using liquid chromatography-tandem mass spectrometry (LCMSMS) and secondly, to identify novel bloodspot markers that may improve screening sensitivity for CAH. In a prospective study, the existing second-tier screening immunoassay was replaced with a …
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Comparing diene derivatisation methods of dry blood spot samples for vitamin D metabolites quantification by liquid chromatography-tandem mass spectrometry
… serum and dry blood spot samples (DBS) using the liquid chromatography tandem-mass spectrometry (LC-MS/MS) analytical technique. This manuscript describes in detail the development and validation of an analytical methodology, highlighting the role derivatisation and mass spectrometry plays in the …
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
The aim of this study was to investigate the potential use of ELISA and LC-MS-MS in combination and as individual techniques, for the detection of drugs of abuse in biological matrices. Overall the LC-MS-MS method showed good correlation results for opiates compared to the GC-MS method. 6-MAM was …
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Monoclonal Antibody Therapy: The Development of a Liquid Chromatography Tandem Mass Spectrometry Method to Measure Rituximab Concentrations in Human Plasma
… appropriate sample preparation techniques and liquid chromatography tandem mass spectrometry (LC-MS/MS) as the detection method. This was achieved by employing a bottom-up approach, culminating in the identification of a target peptide that serves as a representative of RTX. Sample preparation …
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Investigation of occurrence, elimination and degradation of pharmaceutical and personal care products in drinking water using liquid chromatography-tandem mass spectrometry
… In this research project, a comprehensive liquid chromatography tandem mass spectrometry method has been developed and validated for the analysis of sixteen pharmaceutical compounds using solid phase extraction. Treated and untreated water samples collected across Missouri from water …
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Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry And Elisa Determination Of Caffeine As A Marker For Sewage Contamination Of Wilgreen Lake
… and its tributaries, and analyzing them using liquid chromatography-tandem mass spectrometry coupled to an Electrospray Ionization (ESI) Interface. An isotope dilution method using 13C3-labeled caffeine as the internal standard was adapted from known methods and employed to determine and …
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Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
… three semiquantitative ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) methods for the screening of 15 SARM compounds (equine, bovine, canine, rodent and human) with and without enzymatic hydrolysis (β-glucuronidase/arylsulfatase) in urine and in blood …
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Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry
… and amphetamine, in hair using High Performance Liquid Chromatography coupled to Mass Spectrometry.
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F₂-isoprostanes study after exposure to selected nanoparticles by liquid chromatography/tandem mass spectrometry and investigation of nanoparticles on the cytotoxicity effect of arsenic in vitro
… were quantified by high performance liquid chromatography/mass spectrometry followed by the exposure of SiO₂ (15 nm), CeO₂ (20 nm), Fe₂O₃ (30 nm), and ZnO (70 nm) nanoparticles for 24 hours. For the first time, the results showed that F₂-isoprostanes levels increased significantly in …
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A prospective study to assess the value of liquid chromatography-tandem mass spectrometry in the management of paediatric poisoning at Red Cross War Memorial Children's Hospital, Cape Town, South Africa
… There is a paucity of data on the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS), in the management of paediatric poisoning in low-and middle-income countries (LMICs). In high-income countries, most studies are retrospective, and few include children. Objective: The study …
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Characterizing blood plasma proteins from organ tissue in rainbow trout (Oncorhynchus mykiss) using a non-targeted proteomics approach
… plasma and tissue proteins were analyzed using liquid chromatography tandem mass spectrometry. Over 10,000 proteins were identified across all groups. Majority of the plasma proteome is shared with multiple tissue types, though 4-7% of the plasma proteome is uniquely shared with each tissue …
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Stability of heroin metabolites and oxycodone in rat hair and liver during decomposition
… analysed in hair samples by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Oxycodone concentrations in both hair and liver decreased as the interment period and decomposition of the carcasses progressed. 6-Monoacetylmorphine was not detected in any hair samples …
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The association between circulating vitamin d levels and body composition in collegiate female athletes
… fingerstick and dried blood spots, followed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). In addition, sunlight badges worn during a 24-hour period assessed sunlight exposure in fall and spring seasons. Estimated dietary vitamin D intake assessed via Vitamin D Food Frequency …
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Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices
… When using reversed-phase high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), analyte retention and sensitivity are increased after derivatization, 6.7-fold for glufosinate and 6.3-fold for 3-MPPA. TrEnDi methodology was applied to canola samples from two separate …
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Towards Rapid Measurement of Non-Nucleoside Reverse Transcriptase Inhibitors in a Portable, Low-Cost Platform
… Most DLF approaches measure drug levels via liquid chromatography-tandem mass spectrometry (LC-MS/MS), which can incur high costs and lengthy delays that make it unsuitable for near point-of-care settings. In response, we developed a rapid enzymatic assay for the measurement of non-nucleoside …
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Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children
… in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior …
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