Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Liquid chromatography coupled to mass spectrometry"”.
-
From Small Molecules to Neurotoxins: Characterizing Neuromodulatory Compounds Using Liquid Chromatography Coupled to Mass Spectrometry
Thus, this work demonstrates mass spectrometric approaches for analyzing biological samples from a variety of animal models resulting in detailed chemical and structural characterization of highly modified toxins, neuropeptides, and small molecules, which can ultimately contribute to our …
-
Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry
… as an alternate or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide a long-term history of an individual’s drug use. There are several practical applications of hair …
-
The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells
… carnosine for the treatment of glioblastoma, we investigated which proton-coupled oligopeptide transporters (POTs) are present in glioblastoma cells and how they contribute to the uptake of carnosine. Therefore, mRNA expression of the four known POTs (PEPT1, PEPT2, PHT1, and PHT2) was …
-
Neuropeptidomics: MS-base peptide identification and quantitation study
Neuropeptidomics refers to a global characterization approach for the investigation of neuropeptides, often under specific physiological conditions. Neuropeptides comprise a complex set of cell-to-cell signaling molecules that are important in regulatory functions and behavior in the nervous …
-
Chemical and spectroscopic studies of the capsular polysaccharides of some Klebsiella serotypes
… resulting from conversion of uronic acid to the 4,5-unsaturated analogue where, as found for serotype K64, the mode of cleavage is β-elimination not hydrolysis. The oligosaccharides thus generated have proved to be far more amenable to chemical and spectroscopic studies than their parent …
-
Metabolomic profiles of Oryza sativa and influence of genetic diversity
… Rice (Oryza sativa L.) is an ideal candidate to study traits related to health due to its importance as both a global staple food and a model system for cereal crops. Evaluating metabolite profiles can be a high-throughput method to identify variation in health properties of dietary …
-
Identification of Quorum Sensing Genes in Halococcus Hamelinensis SP. Nov. 100Na1
… releasing chemical and protein signals called autoinducers in order to control and regulate specific gene expression. The process of cell-to-cell communication is termed quorum sensing (QS). According to cell density, if a specific threshold concentration of autoinducers is reached, the …
-
A peptidomic investigation into enteroendocrine cells and islets of humans and mice
… and responding by secreting peptide hormones to control various physiological functions. This thesis focuses on characterising the peptidome of EECs and islets by utilising liquid-chromatography coupled to mass spectrometry (LC-MS). Due to their ability to control food intake and glucose …
-
Applications of metabolomics to study the pathophysiology of adverse pregnancy outcomes
… is a growing field of research aiming to use metabolomic techniques to gain further knowledge into diseases, the use of biomarkers to predict their onset, or the effect of a potential therapeutic agent on the metabolome. Adverse pregnancy outcomes, such as small for gestation age (or …