Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Lipoproteins, LDL"”.
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Anti-diabetic properties of GUH
… cholesterol, tri-acylglycerol (TAG), low density lipoproteins LDL, and high density lipoproteins (HDL) were measured. Results: The effect of GUH in MD fed rats was not marked. However, food intake and weight gain and total cholesterol were lower than in control animals. In HFD fed animals GUH, …
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The influence of oxidised low density lipoproteins on platelet activation
The oxidation of low density lipoproteins (LDL) may contribute to platelet hyperactivity and thrombotic events in cardiovascular diseases. Although these pathological particles are known to stimulate platelet activation, the exact signalling mechanisms involved are poorly defined. The aim of this …
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The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
… appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels …
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The effect of isoflavone supplementation on cardiovascular disease parameters in men undergoing 80% VO₂pk exercise
… effects of oxidative damage on low density lipoproteins (LDL). Current research shows that dietary antioxidant supplementation protects against oxidative stress, and therefore may present preventative measures and treatments for patients with diseases influenced by oxidative stress. …
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Antioxidant Nanoparticles as Delivery Systems
… molecule looks for protection of low density lipoproteins (LDL) from oxidation by placing at the LDL interface two potent natural antioxidants. The LDL protection can impact the development and outcome of atherosclerosis. The approach followed was to use the phytyl chain as active site for …
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Evaluation of the Effect of the Clinical-Decision-Support Systems on Diabetes Management: A Multivariate Meta-Analysis Comparison with Univariate Meta-Analysis
… based on three indicators. Low-density lipoproteins (LDL), glycated hemoglobin (HbA1c), and blood pressure (PB) have been used as indicators of diabetes care management according to the National Institute for Health and Care Excellence (NICE) guidelines. To combine the results from …
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Estrogen replacement in ovariectomized rats fed safflower oil, coconut oil or cocoa butter: the effects on blood lipids and lipoproteins
… oil. Chemical composition of very low density lipoproteins (VLDL) isolated by gel filtration chromatography revealed high levels of cholesterol and protein when rats were fed cocoa butter, and the elevation of cholesterol and protein was especially prominent in VLDL of intact rats. A …
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Metabolomics in endotoxemia and oral infections
… including increased very- low-density (VLDL) and low-density lipoproteins (LDL), and small triglyceride-rich high-density lipoprotein (HDL) particles. We also observed associations with decreased degree of fatty acid unsaturation and reduced proportions of polyunsaturated omega-3 and …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
The Low-Density Lipoprotein Receptor gene family is a group of ancient membrane receptors. Originally implied in cargo transport and development of atherosclerosis, the number of members and the diversity of functions have been greatly expanded. LRP1, LRP1b and LRP4 are gene family members that are …
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The Hydrophobic Handoff Between NPC2 and the N-Terminal Domain of NPC1 in the Export of Cholesterol from Lysosomes
Low density lipoproteins (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes where its cholesterol is released. Egress of cholesterol from late endosomes and lysosomes (hereafter referred to …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
Low density lipoproteins (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes, allowing cholesterol to be released. Export of cholesterol from late endosomes and lysosomes (hereafter referred …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… fatty acid docosahexaenoic acid (DHA). The LDL-DHA nanoparticle has demonstrated cancer selective cytotoxicity with little ill effects on healthy cells. Our research began by selecting a panel of breast cancer cell lines representative of the various subtypes of clinical breast cancer. This …
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Type 2 diabetes mellitus and dyslipidaemia: effects of genetic variation in African populations
Background: Low-density lipoproteins (LDL) have been associated with damage to the cardiovascular system in patients with type 2 diabetes mellitus (T2DM). These patients are two (2X) to four (4X) times more likely to develop cardiovascular diseases (CVD) compared to non-diabetic patients due to …
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The Effects of Lowering Cholesterol on Vasodilation
… drop in both the total cholesterol and LDL-cholesterol in the lifestyle and medication groups, but no change in the HDL-cholesterol in all three groups. This contradicts previous research showing that HDL-cholesterol levels decrease with low fat diet.</p>
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Molecular Probes for Biologically Important Molecules: A Study of Thiourea, Hydroxyl radical, Peroxynitrite and Hypochlorous acid
… aromatic side chains. Low density lipoprotein (LDL) carries cholesterol in the human body. Elevated concentration of LDL is a potential risk factor for atherosclerosis. Previous research drew a strong correlation between oxidized low density lipoprotein (ox-LDL) and plaque formation in the …
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The role of lipoproteins in vascular calcification and plaque stabilisation
… and larger sheets decrease likelihood. Although lipoproteins, namely high (HDL), low (LDL), very low (VLDL) density lipoproteins and lipoprotein (a) (Lp(a)), have been previously studied in their relationship to general plaque growth and progression, their roles in influencing plaque …