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Showing 1 to 15 of 15 for “"Lipoproteins, HDL"”.
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, characterized by extremely low plasma HDL cholesterol (HDL-C) levels and widespread storage of cholesterol …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
The esterification of cholesterol on high density lipoproteins (HDL) catalyzed by lecithin:cholesterol acyltransferase (LCAT) maintains a gradient for cholesterol diffusion from cell membranes and atherosclerotic plaques and plays a critical part in the maintenance of cholesterol homeostasis. The …
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Anti-diabetic properties of GUH
… cholesterol, tri-acylglycerol (TAG), low density lipoproteins LDL, and high density lipoproteins (HDL) were measured. Results: The effect of GUH in MD fed rats was not marked. However, food intake and weight gain and total cholesterol were lower than in control animals. In HFD fed animals GUH, …
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Structure, Assembly, and Maturation of High -Density Lipoproteins
High-density lipoproteins (HDL) are protein-lipid particles that are involved in the transport of cholesterol in the blood. They are of great importance in the treatment of coronary heart disease as low levels of HDLs are a known risk factor for the development of arteriosclerosis. Little is known …
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Structure, Assembly, and Maturation of High-Density Lipoproteins
High-density lipoproteins (HDL) are protein-lipid particles that are involved in the transport of cholesterol in the blood. They are of great importance in the treatment of coronary heart disease as low levels of HDLs are a known risk factor for the development of arteriosclerosis. Little is known …
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A Characterization of the Effect of Apolipoprotein AII on the Structure and Function of Apolipoprotein AI in Reconstituted High Density Lipoproteins
High density lipoproteins (HDL) can be fractionated by immunoaffinity chromatography into two main subclasses: a fraction which contains apolipoprotein (apo) AI and apoAII, and a fraction which contains apoAI but not apoAII. The effect of apoAII on the structure and function of apoAI in …
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The study of spherical high-density lipoproteins and the intermediates involved in their formation
High density lipoproteins (HDL), which are found as spherical particles in the circulation, contain a core of neutral lipids, mainly cholesterol esters and an outer shell of apolipoproteins, phospholipids, and cholesterol. Discoidal HDL, discovered in the plasma of patients deficient in lecithin …
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Apolipoprotein M – Studies of Structure and Function
… although the majority is found in high density lipoproteins (HDL). ApoM has been suggested to be involved in the formation of and adding to the antiatherogenic functions of HDL, but its function is still not completely known. ApoM has been suggested to be a lipokalin. By studies in vitro using …
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The role of high density lipoprotein compositional and functional heterogeneity in metabolic disease
High density lipoproteins (HDL) are complexes of phospholipid, cholesterol and protein that circulate in the blood. Epidemiological studies have demonstrated a strong inverse correlation between plasma levels of HDL associated cholesterol (HDL-C) and the incidence of cardiovascular disease (CVD). …
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Estrogen replacement in ovariectomized rats fed safflower oil, coconut oil or cocoa butter: the effects on blood lipids and lipoproteins
… oil. Chemical composition of very low density lipoproteins (VLDL) isolated by gel filtration chromatography revealed high levels of cholesterol and protein when rats were fed cocoa butter, and the elevation of cholesterol and protein was especially prominent in VLDL of intact rats. A …
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Analysis of the function and subcellular localization of FAT/CD36 in hepatocytes and transfected cell lines of hepatic and non-hepatic origin.
… and uptake of oxidatively damaged low-density lipoproteins (oxLDL). In adipose and muscle tissues, FAT/CD36 mediates high-affinity binding and uptake of long-chain fatty acids (LCFAs) and is therefore a key regulator of lipid storage (particularly in adipocytes) and mitochondrial beta oxidation …
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… circulating levels of high density lipoprotein (HDL) cholesterol. The atheroprotective nature of HDL is attributed mainly to its role in reverse cholesterol transport (RCT). However, recent reports of human and animal studies have suggested that the atheroprotective nature of HDL is not …
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HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease
… levels of high-density lipoprotein cholesterol (HDL-C) are strongly inversely associated with coronary artery disease (CAD), and high HDL-C is generally associated with apparent ‘protection’ from CAD. OBJECTIVE: We identified a number of individuals with high HDL-C levels who develop CAD, a …
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… efflux capacity of cholesterol to high-density lipoproteins (HDL), accompanied by a selective increase in the surface expression of the cholesterol transporter, ATP Binding Cassette Subfamily G Member 1 (ABCG1), whose mechanistic basis requires deeper evaluation. Moreover, it mitigates …