Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Lipoprotein Particles"”.
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The regulation of blood coagulation by high-density lipoprotein particles
High-density lipoprotein (HDL) has anti-atherogenic properties and the plasma level of HDL cholesterol correlates inversely with the risk of coronary artery disease. The atheroprotective functions of HDL can be explained by its function in the reverse cholesterol transport. Blood coagulation is …
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
The Drosophila Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show …
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Studies of G-Protein Coupled Receptors Incorporated Into a Novel, Nanoscale, Membrane-Mimetic System
<p>From first principles of phospholipid — apolipoprotein A-I (apo A-I) interactions, we hypothesized that the amino acid sequence of apo A-I derived from a different species may exhibit improved properties compared to human apo A-I for the purpose of incorporation of G protein-coupled receptors …
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The Golgi Complex of the Hepatocyte: Isolation and Partial Enzomological Characterization
… by their content of 30-80m osmiophilic particles, which have been identified by others as very low density lipoprotein. The vast majority of such particles in the cell are in the elements of the Golgi complex. Moreover, the number in the complex can be increased still further by acute …
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Application of All-Atom and Coarse-Grained Molecular Dynamics Simulations to Long Timescale Structural Transitions of Proteins
… the assembly and disassembly of high density lipoprotein particles, and the rotation of the bacterial flagellum. In each case, molecular dynamics simulations provided qualitatively new insights that are in line with previous, contemporary or subsequent experiments. In addition to exploring how …
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Dietary amino acids and their contribution to de novo lipogenesis
… in plasma and liver-derived very low-density lipoprotein particles in samples from human subjects. The underlying mechanism behind this increase in lipogenesis by dietary amino acids was investigated in vitro. In hepatocytes, glutamate derived carbon was incorporated into palmitate and …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… that high plasma levels of high-density lipoprotein (HDL) protect against cardiovascular disease and accumulating evidence indicates that the beneficial role of HDL extends to the central nervous system. There are several important biological mechanisms that regulate HDL generation and …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
Several apolipoproteins (apo) can impact triglyceride (TG) transport by modulating VLDL assembly and secretion. Here we explore the impact of apoA-IV on VLDL particle expansion. Previous studies demonstrated that apoA-IV expression promotes apoB lipoprotein-mediated TG secretion in transfected …
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Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… involves the retention and modification of lipoprotein particles. Macrophages and vascular smooth muscle cells (VSMCs) in the arterial wall respond by ingesting large quantities of the modified lipoproteins, such as oxidised low-density lipoproteins (oxLDLs), which are then metabolised to …
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Analysis of membrane systems using lipoprotein nanodiscs
… their analysis challenging. Engineered nanoscale lipoprotein Nanodiscs provide a well-defined and native-like lipid bilayer to solubilize membrane proteins and lipids. This dissertation details the analysis of Nanodiscs containing various membrane proteins and lipids with bioanalytical methods, …
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Metabolite Profiling: Correlates and Associations with Incident Cardiovascular Outcomes
… analyses aiming to improve understanding of lipoprotein characteristics and CVD, I assessed detailed associations of particle concentrations and sizes of lipoproteins with incident cardiovascular events among 135,035 participants (~ 3,800 cases) from UKB and INTERVAL studies, as well as …