Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Lipophilic drugs"”.
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… technique for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. Propofol, a sedative and anesthetic drug was chosen as a one of the model lipophilic drug in …
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Cardioprotective Effect of Lipid Emulsion on Acute Exogenous Drug Intoxications // Кардиопротективен ефект на липидна емулсия при остри екзогенни интоксикации с медикаменти
… neuroleptics, and cardiovascular drugs being the most commonly overdosed drugs. Most of these do not have a specific antidote and cause serious and sometimes fatal cardiovascular and neurological complications, necessitating the introduction into the routine practice of more …
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Use of nanoemulsion liquid chromatography (NELC) for the analysis of inhaled drugs. Investigation into the application of oil-in-water nanoemulsion as mobile phase for determination of inhaled drugs in dosage forms and in clinical samples.
… technique is not good at separating hydrophilic drugs of very similar chemical structures. Different phase diagrams of oil (octane or ethyl acetate), co-surfactant (butanol), surfactant (sodium dodecyl sulphate (SDS) or Brij-35) and buffer (Phosphate pH 3) were developed and several nanoemulsion …
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Nanostructured materials for hydrophobic drug delivery
… do not pose heavy issues to the release of lipophilic drugs, provided that a suitable surfactant (either Tween-20 or Tween-80) mediates the molecule solvation and its subsequent release into aqueous media. Moreover, NC gels protect BC from degradation much better than its storage in freezer …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
… as a viable modality to deliver therapeutic drugs for the treatment of eye diseases. Although several studies have been conducted to examine the utility of iontophoresis for both charged and neutral molecules, the understanding of the mechanisms controlling the iontophoretic delivery of …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… TPGS as potential delivery cargos to treat AMD. Lipophilic drugs such as etodolac (ETD), oxaprozin (OXP) and indomethacin (IN) were successfully encapsulated in the hydrophobic core of the nanomicelles with enhanced solubility. Nanomicellar formulations decorated with hyaluronic acid (HA) were …
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Solubility enhancement of poorly water soluble drugs using liposome technology
… that could control the encapsulation of lipophilic drugs and investigate the influence of the physical properties of poorly water-soluble drugs on bilayer loading. Initial work investigated on the solubilisation of ibuprofen, a model insoluble drug. Drug loading was assessed using HPLC …
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Studio di formulazione e caratterizzazione di nanoparticelle a base di trimetil chitosano e sodio alginato per il rilascio mirato di farmaci
… been used for the encapsulation of two model drugs for nose to brain drug delivery, progesterone (PG-NPs) and levodopa (LD-NPs), at different concentrations. Indeed, recent developments have proved the possibility of using the nasal pathway for direct transport of drugs from nose to brain. …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… behaviour and uptake of orally administered drugs. Bile salts have long been appreciated within the pharmaceutical field to be efficient solubilizers of lipophilic drugs. It is also now known that bile salts are important signalling molecules, with the potential to regulate …
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Caratterizzazione dimensionale e morfologica di nanoparticelle lipidiche contenenti molecole farmacologicamente attive
… they could be good candidates for potent but lipophilic drugs that cannot be systemically administered with conventional formulations (e.g., solutions, dispersions). In addition, we focused on their preparation and characterization to evaluate potential therapeutic applications based on shape …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… based on natural compounds, as old synthetic drugs cause numerous side effects. Curcumin (CUR) and astaxanthin (AST) are two natural antioxidants that possess therapeutic properties for the treatment of AD, although they show poor biovailability due to their high lipophilicity. In order to …