Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 234 for “"Lipophilic"”.
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. Propofol, a sedative and anesthetic drug was chosen as a one of the model lipophilic drug in this study. Initially, feasibility of delivery of propofol …
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Synthetic Ion Channels From Lipophilic Guanosine Derivatives
… and other molecular devices. In this thesis, lipophilic guanosine derivatives that combine both "molecular recognition" and "membrane soluble" features are utilized for the development of the self-assembled synthetic ion channels. The potential of lipophilic G-quadruplexes to function as …
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Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers
… a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide).
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Measuring and Comparing the Diffusion Rate of Fluorescent-Lipophilic-Neurotracing Probes in Murine-Peripheral-Nerve Preparations
Lipophilic-fluorescent dyes are used as probes to study the neural pathways that wire the brain. Since these dyes are able to define neuroanatomic connections through all stages of normal and mutant development, they are currently the most comprehensive method for neurotracing. In order to …
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Design of Viscoelastic Surfactant-oil-water Structures with the Hydrophilic-lipophilic Difference (HLD) and Net-average Curvature (NAC) Frameworks
… in turn, can be predicted with the hydrophilic-lipophilic difference (HLD) framework. This approach was successful at predicting the formation of viscoelastic fluids for extended anionic surfactants, and a model anionic surfactant, sodium dihexyl sulfosuccinate for a variety of salinities and …
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Separation of alkali metal cations and alkaline earth cations using ionizable crown ethers
… and crown ether phosphonic acids which possess lipophilic pendant groups were employed for the study of extraction and membrane transport. In addition to mono- and di-ionizable macrocyclic complexing agents, monoand di-ionizable acyclic complexing agents were utilized to probe the effects of …
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Cuticular transport of hydrophilic molecules with special focus on primary metabolites and active ingredients
… of the work done was focused on transport of lipophilic molecules. It is highly plausible to examine the penetration of lipophilic compounds, since the cuticle is dominated by lipophilic compartments itself, and the most crop protection agents have lipophilic character. As a result of this …
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FLUORESCENT PROBE INVESTIGATIONS OF MICROENVIRONMENTS OF ANALYTICAL INTEREST (REVERSED-PHASE, POLYETHYLENIMINE, POLARIZATION)
… reflect the nature and extent of lipophilic interactions. Tetramethylammonium promoted ANS penetration into surface structure. Tetrabutylammonium overcame aqueous surface alkyl aggregation, which greatly enhanced ANS-surface interaction of C18. For the other phases at high cation …
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ΣΥΝΘΕΣΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ- ΟΚΤΑΝΙΟΥ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99Μ
… (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH …
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Cardioprotective Effect of Lipid Emulsion on Acute Exogenous Drug Intoxications // Кардиопротективен ефект на липидна емулсия при остри екзогенни интоксикации с медикаменти
… and subsequently, their ability to capture lipophilic drugs and to retrieve them from target organs such as heart and brain and thus reduce their toxicity, has been demonstrated. (Weinberg, 1998). The questions that remain unresolved are whether LEs have cardioprotective effect when …
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Broccoli Components as Antioxidants: The Role of Isothiocyanates as Redox Modifiers via Glutathiolation
… DCFH, in HepG2 cells) using hydrophilic and lipophilic extracts of broccoli. For lipophilic extracts, ORAC correlated with inhibition of cellular oxidation of DCFH (r = 0.596, p = 0.006). Also, DNA damage inhibition by lipophilic extract was negatively correlated with both chemical and …
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Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
… and, therefore, populations. Persistent lipophilic toxicants acquired with the energy can bioaccumulate and harm individuals. Marine mammals are particularly vulnerable because of their large energy requirements, and transfer of energy and toxicants from mothers to their young during …
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Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
… and, therefore, populations. Persistent lipophilic toxicants acquired with the energy can bioaccumulate and harm individuals. Marine mammals are particularly vulnerable because of their large energy requirements, and transfer of energy and toxicants from mothers to their young during …
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Destruction of biological tetrapyrrole macrocycles by hypochlorous acid and its scavenging by lycopene
… But the reactivity of HOCl extends to the lipophilic compartments as well. Lycopene and its oxidation products are lipophilic in nature. Therefore lycopene oxidative fragments have the potential to be used as a biomarker for HOCl mediated damage to the lipophilic compartments in the …
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Development and Characterization of Fatty Acid-Coated Microgels Within Microfluidic Systems
… pH-sensitive mugels within microchannels, and lipophilic acid chlorides were covalently grafted to these objects with an in situ process. The resulting hydrophobic coatings served as selectively permeable barriers that enabled pH-sensitive mugels to remain contracted while bathed by buffered …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… drug carriers, i.e. efficient encapsulation of lipophilic compounds, to a PLGA system without taking away its various useful qualities. The PONC were formulated by emulsification solvent evaporation technique, which were then characterized for particle size, encapsulation efficiency, drug …
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The multifarious self-assembly of triblock copolymers : from multi-responsive polymers and multi-compartment micelles
… – namely polymers bearing a hydrophilic, a lipophilic and a fluorophilic block – as the driving force for self-assembly in water. The self-assembly of these polymers in water produced polymeric micelles comprising a hydrophilic corona and a microphase-separated micellar core with lipophilic …
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