Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Lipopeptide"”.
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Chemical Synthesis of Novel Calcium-Dependent Lipopeptide Antibiotics
… An important class of AMPs are calcium-dependent lipopeptide antibiotics (CDLAs) of which daptomycin is the only novel antibiotic introduced for clinical use in the last 20 years. Recently, metagenomic mining emerged as a novel platform for discovery of clinically relevant natural products …
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Domain Redistribution in Lipid Bilayers in the Presence of the Antimicrobial Lipopeptide Fengycin
… mechanisms of action of the antimicrobial cyclic lipopeptide fengycin on model membranes. Total internal reflection fluorescence (TIRF) microscopy was used to visualize and analyse lipid phase separation within supported lipid bilayers (SLBs) of various compositions. The initial research …
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Biological activity and regulation of cyclic lipopeptide production in Pseudomonas corrugata and Pseudomonas mediterranea
… The interest of our work focused on cyclic lipopeptides (CLPs) that are surface active molecules with antibacterial, antifungal and cytotoxic properties. P. corrugata is known to produce two kinds of cyclic lipopeptides, corpeptins and cormycin A. Investigations on P. corrugata strain …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… of TLR1 and TLR2 and the synthetic triacylated lipopeptide agonist Pam3CSK4. Importantly, addition of sub-stoichiometric amounts of either LBP or sCD14 significantly enhances formation of a TLR1/TLR2/Pam3CSK4 ternary complex as measured by size exclusion chromatography. However, neither LBP nor …
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Biocontrol of Rhizoctonia Solani on Soybean With Bacillus Amyloliquefaciens Producing Iturin A
… that they belong to iturin A, a group of cyclic lipopeptide antibiotics normally produced by Bacillus subtilis. One compound, with a mass of 1042.5533, was identified as iturin A$\sb2.$ The remaining two compounds are closely related to iturin A$\sb2$, may be iturin A$\sb4$ and A$\sb7,$ …
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Molecular Basis of Cell Membrane Adaption Against Daptomycin in Enterococcus faecalis
<p>Daptomycin is a last-resort lipopeptide antibiotic that disrupts cell membrane (CM) and peptidoglycan homeostasis (Grein et al., 2020a; Müller et al., 2016a). Enterococcus faecalis has developed a sophisticated mechanism to avoid daptomycin killing by redistributing CM anionic phospholipids away …
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Identifizierung, Klonierung und Sequenzierung der 1,3-ß-D-Glucan-Synthetase bei der humanpathogenen Hefespezies Candida glabrata
… der Echinocandine, echinocandin ähnlicher Lipopeptide und Pneumocandine, wovon einige in klinische Versuche aufgenommen wurden. In dieser Arbeit wurde ein FKS homologes Gen von C. glabrata identifiziert, kloniert und sequenziert. Die erhaltene Gensequenz des gefundenen FKS-Homologs von …
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The effect of age on human monocyte epigenetics and function
… response to bacterial lipoprotein and lipopeptide. The study attempted to filter the large RRBS experimental dataset using CpGs identified by Horvath (2013), to reduce the dataset and enrich it for age-associated regions. This only revealed one region, possibly due to the differences in …
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Convergent Site-Selective Carbohydrate-Peptide Ligations With Dehydroalanine and Aziridine -2 -Carboxylic Acid-Containing Peptides
… construction of a variety of glycopeptide and lipopeptide conjugates for biological evaluations.
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Screening and evaluation of bacteria for the biological control of Botrytis cinerea on Vitis vinifera
… (PCR) was used to detect genes related to cyclic lipopeptide (CLP) synthesis, and liquid chromatography-mass spectrometry was used to determine if CLPs were expressed.
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Multiple gene contribution to the phenotypic and genotypic Daptomycin non-susceptible (DNS) variants of Methicillin-Resistant Staphylococcus aureus isogenic strains
Daptomicina (DAP), un lipopeptide ciclico, costituisce ad oggi una valida alternativa per il trattamento delle infezioni da Staphylococcus aureus multi-resistente (MDR) che non rispondono alla terapia con vancomicina. Case reports di fallimenti terapeutici associati a ridotta sensibilità a DAP …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… with 75 ligands before RVFV infection. The lipopeptide Pam3CSK4 decreased RVFV and LACV infection in neurons and the mouse brain by blocking viral fusion. Additionally, two beta glucans were antiviral specifically in neurons, and likely decreased viral entry. These data clarify the …
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Secondary Metabolite Production By An Endophytic Bacillus sp. from Platanus Occidentalis
… genus were identified using LC-MS including the lipopeptide fengycins, surfactins, and iturins. Iturin A3 was isolated and characterized from the endophyte, and found in the host P. occidentalis, as shown by LC-MS. The presence of a possible rapamycin analogue was discovered which would be …
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Synthetic Studies Towards the Total Synthesis of Apoptosis Inducing Natural Products, Jahanyne and Opaliferin
… N-methylated alkynyl fatty acid-containing lipopeptide, jahanyne (18), which was isolated from the methanol extract of the marine cyanobacterium Lyngbya sp., and exhibited inhibitory activity against the growth of HeLa cells (IC50 1.8 uM) and HL60 cells (IC50 0.63 uM), and was also shown to …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… explores the total chemical synthesis of the lipopeptide antibiotic daptomycin and analogues along with evaluation of their antibacterial activity. Tikitericin is a newly described lanthipeptide characterized by four intramolecular thioether linked (methyl)lanthionine bridges. It was isolated …
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Ecology and Synthetic Biology as Tools for Natural Products Discovery From Marine Proteobacteria
… production of a variant of the highly modified lipopeptide, alterochromide. This thesis represents the culmination of original research in uncovering a portion of the biosynthetic potential of marine bacteria and forming links to the genetic and enzymatic determinants of that biosynthetic …
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Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
… production. Finally, the ability of a bacterial lipopeptide to stimulate polyclonal antibody production only in AOAH -/- mice suggests that the enzyme may also regulate immune responses to non-LPS bacterial agonists.
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Structural and kinetic studies of surfactant and phospholipid monolayers at the air/liquid interface using sum-frequency generation spectroscopy
… The structure of surfactin, a surface-active lipopeptide, was investigated at the air/water interface. Deuterated analogues of the bio-surfactant were produced from \textit{Bacillus Subtilis} by feeding the bacteria with deuterated glucose and/or deuterated leucine. These analogues were used …
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… that our lab previously discovered cilagicin, a lipopeptide natural product that shows robust Gram-positive antibiotic activity and evades antibiotic resistance even after prolonged pathogen exposure. This resistance evasion is attributed to a dual polyprenyl phosphate binding mechanism. In this …
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