Global ETD Search
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Showing 1 to 12 of 12 for “"Lipooligosaccharide"”.
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Antigenic Characterization of <I>Haemophilus somnus</I> Lipooligosaccharide
Lipooligosaccharide (LOS) is the major outer membrane component of many Gram-negative bacteria inhabiting the mucosal membranes, including pathogenic species of <I>Haemophilus</I> and <I>Neisseria</I>. LOS phase variation is one mechanism by which some of these bacteria avoid the host immune …
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Characterisation of the lipooligosaccharide biosynthesis gene cluster in campylobacter species
The extensive genetic variation in the lipooligosaccharide (LOS) core biosynthesis gene cluster, a majority of which occurs in the LOS outer core biosynthesis gene content present between lgtF and waaV, have led to the development of a classification system; with 8 classes (I-VIII) for …
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Cloning and Characterization of a Gene Involved in Lipooligosaccharide Biosynthesis in Haemophilus somnus
… are present in several loci associated with lipooligosaccharide (LOS) phase variation in Haemophilus influenzae type b (Hib). In an attempt to identify H. somnus phase-variable LOS genes, the presence of CAAT repeats within the H. somnus 738 genome was confirmed using a (CAAT)7 probe. A 3.9 …
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Investigation of Haemophilus somnus Virulence Factors: Lipooligosaccharide Sialylation and Inhibition of Superoxide Anion Production
… Brucella abortus. Non-viable H. somnus, purified lipooligosaccharide (LOS), or cell-free supernatant from mid-log phase cultures did not inhibit O2- production, indicating that O2- inhibition required contact with live H. somnus. Commensal isolates of H. somnus were less capable or incapable of …
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Effect of Sialylation of Histophilus somni Lipooligosaccharide on Virulence and Resistance to Host Defenses
… neuraminic acid (NANA), or sialic acid, onto lipooligosaccharide (LOS) enhances the virulence of several bacterial species. In the present study, we assessed the effect of sialylation of Histophilus somni LOS on complement-mediated killing, binding of complement factor H (which converts C3b to …
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The Molecular Characterization of Phosphorylcholine (ChoP) on Histophilus somni Lipooligosaccharide: Contribution of ChoP to Bacterial Virulence and Pathogenesis
… include expression and antigenic variation of lipooligosaccharide (LOS). Phosphorylcholine (ChoP) is often expressed on H. somni LOS and also undergoes antigenic variation. In this study, five genes that play a role in expression and antigenic variation of ChoP, lic1ABCD and glpQ, were …
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<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
… These results suggest that factors other than lipooligosaccharide (LOS) contribute to IL-8 secretion.</p>
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Genome sequence of the hyperinvasive Campylobacter jejuni strains
… an overall genetic variability and the capsule, lipooligosaccharide, flagellar biosynthesis and restriction modification regions were the most diverse. The hierarchical clustering based on comparative genomic hybridization (CGH) did not group together the hyperinvasive C. jejuni as a single group …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… in H. somni of which the phase-variable lipooligosaccharide, induction of host cell apoptosis, intraphagocytic survival, and immunoglobulin Fc binding proteins were well characterized. To further understand the biological properties of H. somni, the genomes of pneumonia strain 2336 and …
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Towards Novel Methods of Mutagenesis for Histophilus somni
… in H. somni include biofilm formation, lipooligosaccharide phase variation, immunoglobulin binding proteins, survival in phagocytic cells, and many others. To identify genes responsible for virulence, an efficient mutagenesis system is needed. Mutagenesis of H. somni using allelic …
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The role of lipid A in the virulence of ESKAPE pathogens
… all<br/>hospitalised cases. Lipopolysaccharide/lipooligosaccharide (LPS/LOS) present on the outer membrane of Gram-negative pathogens is the main sepsis-inducing agent known for its significant inflammatory capabilities during septic shock.<br/><br/>Here we investigated the lipid A anchoring …
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IN VITRO SUSCEPTIBILITY OF CHLAMYDIA TRACHOMATIS TO LPS-BINDING POLYAMINES AND CELLULOSE ETHER POLYMERS: TOWARDS THE DEVELOPMENT OF A MICROBICIDE AGAINST CHLAMYDIA INFECTION
… in studying the biological role of chlamydial lipooligosaccharide (LOS), using small molecule DS-96 targeting lipid A as a chemical probe. DS-96 effectively blocked chlamydial attachment and entry steps, suggesting that chlamydial LOS plays a role in these steps. These data were supported by …