Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Lipolysis"”.
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Characterization of coconut oil and CLA induced lipolysis
… objectives were to determine if the CLA-induced lipolysis in different oil source-fed mice was time-dependent and to determine the effect of cell signaling inhibitors on CO+CLA-induced lipolysis. Study 1: Male mice (ICR; n=80; 3wk) were fed 7% soybean oil (SO) or CO diets for 6wk and then …
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Interventions against obesity through increased lipolysis in adipose tissue
… against obesity in which adipose tissue lipolysis will be combined with increased energy expenditure: the approach is also designed to consider agents that will benefit glycaemic control in coexistent obesity and diabetes by improving insulin sensitivity. Rodent and human in vitro models …
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Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity
… Two major processes occurring in adipocytes are lipolysis (lipid mobilization) and lipogenesis (lipid formation), which are controlled by different metabolic hormones. Potential differences in these processes or hormone sensitivity may predispose OP rats to develop obesity or protect OR rats from …
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Molecular Dissection of Bsc2: A Novel Negative Regulator of Triglyceride Lipolysis for a Lipid Droplet Subpopulation
… LDs, and reveal it negatively regulates TG lipolysis. Mechanistically, Bsc2 LD targeting requires TG, and LD targeting is mediated by specific N-terminal hydrophobic regions (HRs) sufficient for Bsc2 function. Molecular dynamics simulations reveal these Bsc2 HRs interact extensively with TG …
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The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
… influence of local estradiol on adipose tissue lipolysis as well as estrogen receptor content and adipocyte size in abdominal and gluteal subcutaneous adipose tissue of overweight-to-moderately-obese premenopausal women. Eighteen overweight-to-moderately-obese Caucasian (CA, n=9) and African …
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Functional validation of human rare missense variants associated with body fat distribution and cardiometabolic risk
… implicated in the regulation of intracellular lipolysis. In this cell model, Plin1 depletion resulted in an increase in basal lipolysis while isoproterenol stimulated lipolysis was suppressed. Pnpla2 depletion, on the other hand, impaired lipolysis under both basal and stimulated conditions. …
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The role of skeletal muscle PLIN proteins at rest and following lipolytic stimulation
… effects of contraction and epinephrine-induced lipolysis. This method allowed for the examination of the effects of contraction and epinephrine alone and in combination. Further, the soleus was chosen for investigating the role of PLIN proteins in skeletal muscle lipolysis due to its suitability …
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Acipimox during Short-Term Exercise Exerts A Negative Feedback of Growth Hormone on Ghrelin Secretion in Patients with Bulimia Nervosa and in Healthy Women: The Role of Lipolysis
Název: Perorální podání acipimoxu během fyzické zátěže způsobuje negativní zpětnovazebný mechanismus růstového hormonu na sekreci ghrelinu u pacientek s mentální bulimií a zdravých žen: Úloha lipolýzy Úvod: Poruchy příjmu potravy, ke kterým patří mentální bulimie (MB) a mentální anorexie, jsou …
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Effects of Neuropeptide Y on Adipocyte Metabolism
… isoproterenol (P-adrenergic agonist) stimulated lipolysis. This potentiation occurred upstream of adenylyl cyclase, since NPY did not enhance forskolin (direct activator of adenylyl cyclase) stimulated lipolysis. The potentiation was mediated by increased phosphorylation of hormone sensitive …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… We also explored the relationship between lipolysis and oxidative gene expression in AT. β3-AR stimulation increased the expression of oxidative genes (PCG1á, UCP1 and NOR-1) in WAT of mice, which was greatly potentiated by inhibition of hormone sensitive lipase (HSL). In 3T3-L1 adipocytes, …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… glucose and NEFA with rate of lipogenesis and lipolysis in adipose tissues of dairy cows differ for genetic merit (high genetic merit, HGM; low genetic merit, LGM). Adipose tissue biopsies were taken at -21, 7, 28 and 56 d around parturition. The mRNA expression of lipogenic genes; enzymes …
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Mechanisms of growth hormone inhibition of adipose tissue growth
… if GH inhibits fat tissue growth by stimulating lipolysis. In this study, adipose tissue weight and adipocyte size were compared between GH-deficient growth hormone releasing hormone receptor (Ghrhr) homozygous mutant mice (i.e., lit/lit mice), lit/+ mice, and lit/lit mice injected with GH. …
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The role of eicoapentaenoic acid in cancer cahexia
… of anorexia. A 4DkDa factor capable of inducing lipolysis in vitro via an activation of adenylate cyclase (AC) has been isolated from the MAC16 tumour, and the urine of cachectic cancer patients, using a series of ion exchange and gel exclusion chromatography procedures. This lipid-mobilising …
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Minimization of extracellular enzyme production by Pseudomonas fluorescens in a model milk system by controlled oxygen atmospheres
… 02, P. fluorescens numbers, proteolysis, lipolysis, pH, proteinase and lipase activity. The dissolved 02 tension in milk decreased despite a constant supply of 02 during mid-exponential growth phase of P. fluorescens when populations reached 5.0 - 6.5Logi() CFU mL4 under all atmospheric 02 …
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Treating type 2 diabetes through insulin resistance
… of the satiety-inducing agent sibutramine on lipolysis in excised murine and human adipocytes was also investigated. M2 increased lipolysis from normal lean and obese ob/ob mouse adipocytes. Arguably the most important observation was that M2 also increased the lipolytic rate in adipocytes …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
… fractions. Concomitantly, relative abundance of lipolysis substrates triacyl-glyceride and diacyl-glyceride decreased significantly in Jurkat T cells treated with autogramin-2, accompanied by a trend towards decrease in monoacyl-glycerides (p=0.0711). Furthermore, relative abundance of …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… hormone (α-MSH), is anorexigenic and mediates lipolysis in adipose tissue, but effects on fat in avians are unreported. The second objective was thus to determine the effects of exogenous α-MSH on adipose tissue physiology in broiler chicks. Chicks were intraperitoneally injected with α-MSH and …
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INVESTIGATION OF THE CARDIOPROTECTIVE AND HYPOTRIGLYCERIDEMIC POTENTIAL OF ECHIUM OIL AS A BOTANICAL SOURCE OF LONG CHAIN N-3 FATTY ACIDS
… Intravenous injection of detergent to block lipolysis showed that FO-fed mice had decreased plasma TG accumulation compared to EO-fed mice. Surprisingly, hepatic TG content in both the PO- and EO-fed mice was significantly higher than that of FO-fed mice, indicating that EO does not protect …
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The hormonal control of lipid metabolism in sheep
… Since most of the fatty acid released by lipolysis appeared to be re-esterified, observation of glycerol data alone may give a false impression of the extent of fatty acid mobilization or the overall energy balance of the tissue. About 60 - 100% of fatty acid released by lipolysis could be …
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