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Showing 1 to 20 of 20 for “"Lipofuscin"”.
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A Study of Bovine Βeta Lactoglobulin: Its Catalytic Activity and Role in The Biosynthesis Of Cycloretinal, A Key Lipofuscin
The accumulation of lipofuscins such as all-trans retinal dimer/cycloretinal in the retina may contribute to the progression of age-related macular degeneration (AMD). While the biosynthesis of cycloretinal is not fully understood, it has been shown that the milk protein β-lactoglobulin (BLG) can …
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Concentrations and Interactions of Selected Elements in Tissues of Four Marine Mammal Species Harvested by Inuit Hunters in Arctic Alaska, With an Intensive Histologic Assessment, Emphasizing the Beluga Whale
… organic, and total Hg. Although hepatic lipofuscin and metal grains were sometimes co-localized, they more often were not. Because marked lipofuscin deposition occurs independent of Hg, causality between hepatic Hg concentration, lipofuscin deposition, and hepatic lesions cannot be …
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A Comparison of Several Parameters of Aging in Drosophila Melanogaster Under Normal and High Oxygen Tension
… exposed to normal room air. Similar rates of lipofuscin accumulation were noted in both groups of flies as a function of age. Lipofuscin accumulation is an indication of lipid peroxidation damage. If high oxygen tension were the cause of accelerated aging, then the group exposed to the high …
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Biochemical Investigations of Macular Degeneration: The Significance of Protein Oxidation including Novel Methods for Its Study
… autofluorescent lysosomal storage bodies (lipofuscin) during senescence. Lipofuscin is reported to begin accumulating in the human RPE around age 20 and continues to accumulate throughout an individual's life. This progressive accumulation of lipofuscin can eventually occupy a substantial …
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CARATTERIZZAZIONE DEI PIGMENTI DELL'INVECCHIAMENTO NEL CERVELLO UMANO:NEUROMELANINA E LIPOFUSCINE
Neuromelanin and lipofuscin are two pigment that both accumulate in central nervous system with aging. The presence and the morphology of these substances have been described more than one century ago but in the past the two pigments haven’t been unmistakably distinct. Today is important to …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… microscopy, and extensive deposition of lipofuscin was detectable by transmission electron microscopy (TEM). Lysosomal expansion was further evidenced by increased immunodetection of lysosomal associated membrane protein-1 (Lamp-1) and Lysotracker-based flow cytometric analysis. While …
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Identification of new genes and pathways that act to delay C. elegans aging
… accumulate the age-related fluorescent pigment lipofuscin. In this screen, we isolated loss-of-function mutations in the gene kat-1. These mutations confer increased lipofuscin accumulation, short lifespan, and other abnormalities characteristic of premature aging. kat-1 encodes a ketoacyl …
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Effect of Age on the Structure of Meissner Corpuscles in Forepad Digital Pads of Mice
… loss of caveoli, mitochondrial degeneration and lipofuscin accumulation.</p> <p>Intraepidermal terminals were thought to be present only during the period of corpuscle development which extends only to include age 1.5 months. Corpuscle growth and maturation until middle age possibly indicated …
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Senescent Changes in the Kidney of the Yellow Mud Turtle Kinosternon flavescens
… greater deposition of a pigment believed to be lipofuscin or ceroid than did young turtles. Glomeruli in the oldest turtles had significantly fewer glomerular arterioles, and a significant increase in connective tissue in the glomerular tuft. Electron microscope studies indicated that glomeruli …
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Unraveling the Effects of Nicotine-Derived Nitrosamine Ketone (NNK) on Healthy and Neurodegenerative Brain via Intravital Imaging and Multiscale Ex Vivo Imaging Approaches.
… events, similar to CX3CR-1 GFP were found. Lipofuscin autofluorescence was observed in intravital imaging for both PBS and NNK-treated groups and showed overall increase in lipofuscin deposition with NNK treatment over 4 days vs. PBS. Vessel leakage was also increased with NNK. Large-scale …
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Experimental and Computational Methods for Shortwave Infrared Imaging
… incorporation of NIR/SWIR autofluorescence as a lipofuscin specific channel to digitally re-move autofluorescence from multi-fluorophore immuno-stained mouse liver samples. We also explore color deconvolution in histopathology imaging, and develop algorithms to support automated thresholding and …
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Zellbiologische Untersuchung α-Mannosidase-defizienter und Enzym-behandelter Mäuse
… Lücken in der Purkinjezellschicht. Zudem konnte Lipofuscin in Mikroglia nachgewiesen werden. Die Ergebnisse dieser Arbeit zeigen neue sekundäre, durch die lysosomale Speicherung bedingte Veränderungen in der Leber auf, die durch die Enzym-Therapie teilweise therapierbar sind. Weitere …
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
… in the age-related increase in autofluorescent lipofuscin between the retina and the choroid. This prevents the proper deliverance of nutrients to the foundational layer of cells in the retina, leading to oxidative stress-related apoptosis of first the retinal pigmented epithelium (RPE) and then …
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
… were observed in the intracellular levels of lipofuscin (age pigment) with time, but no changes in the generation of free radicals were observed using electron spin resonance spectrometry, cytochrome <i>c</i> reduction or spectrofluorometric techniques (caution should be placed in statistical …
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Developing Tools to Physically Magnify Biological Substrates for Clinical Applications
… fluorescence signals even as it eliminates lipofuscin-associated autofluorescence. Thus, this form of expansionmediated protein decrowding may, through improved epitope access for antibodies, render immunohistochemistry more powerful in clinical science and, perhaps, diagnosis. In the second …
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Stargardt patient experiences in the first gene-based clinical trial for an inherited retinal condition in South Africa
… This vision loss is due to a build-up of lipofuscin in the macula, a part of the retina responsible for sharp central vision. Stargardt disease follows an autosomal recessive inheritance pattern and is currently incurable. This study aimed to explore the expectations and experiences of …
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AN ANATOMICAL AND IMMUNOCYTOCHEMICAL STUDY OF THE PRIMATE TEMPORAL AND FRONTAL CORTEX
… of free ribosomes, compared with the adult. 2) Lipofuscin was absent from the infant neurons. 3) There was a total absence of myelinated fibres from the infant cortex. 4) Axosomatic synapses were commoner in the infant, although as in the adult, neuronal profiles were rarely seen with more than …
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Assessment of Mussel Declines in the Clinch and North Fork Holston Rivers Using Histological Evaluations of Vital Organs
… in both studies had a higher abundance of lipofuscin in kidneys and degraded cytoplasm in the digestive gland diverticula compared to baseline mussels, indicating that captivity influenced mussel tissues. Future studies are needed to more thoroughly address these captivity effects. Both …
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Effects of a dietary antioxidant blend on growth performance, liver function, oxidative stress, and meat and fat quality in pigs and broiler chickens fed diets high in oxidants
… decreased dressing percentage and intensive lipofuscin deposition induced by the high oxidant diet. However, the traits of loin muscle redness and belly firmness were not fully corrected by AOX. The second study was to investigate the antioxidant blend and vitamin E on growth performance, …