Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Lipidomics"”.
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New Analytical Methodologies at the Frontier of Cellular Lipidomics
… interest worldwide, to the point that the term "lipidomics" was coined. This field is a subset of metabolomics, and the interesting point about these two sciences is that they are closest to the phenotype as compared to their "omics" counterparts (genomics, trascriptomics, ...), because …
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Lipoprotein lipidomics in obesity-associated metabolic and hepatic disorders
Over the last few decades, obesity has reached epidemic proportions. Obesity is strongly associated with insulin resistance (IR), hyperglycaemia, mixed dyslipidaemia, and hypertension. These metabolic risk factors, grouped under the definition of the Metabolic Syndrome (MetS), increase the risk of …
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Multiscale MALDI mass spectrometry for tissue, cellular, and subcellular lipidomics
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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DOES FAT MATTER? Lipidomics investigations during Blue mussel (Mytilus sp.) hatchery production
… liquid chromatography-mass spectrometry (LC-MS) lipidomics.<br/>Through these approaches, I described the gonad lipidome in the testis and ovary and the acclimation responses to different temperature programmes during BSC in broodstock gonad lipidome. Furthermore, the integration of gonad …
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Microbial responses to environmental forcing and implications for trophic transfer through the lens of lipidomics
… energy within the ecosystem. Through the lens of lipidomics, I explored phytoplankton responses to nutrients in the North Pacific Subtropical Gyre (NPSG), and to light in the western Antarctic Peninsula (WAP). In the NPSG, I utilized lipid biomarkers to differentiate between cyanobacterial and …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
Background: Gestational physical activity (PA) has been associated with a multitude of positive outcomes for both the gestational parent and the offspring. Given the placenta’s central role in supporting pregnancy, it is likely involved in mediating these benefits, though the mechanistic …
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Natural variation in the human plasma lipidome signature using mass spectrometry: relevance to healthy ageing
… brain health an important research priority. Lipidomics, a subfield of omics, involves characterisation and quantification of total lipids in biological systems. Since brain lipids influence protein function and synaptic throughput in neurons, lipidomics may help to uncover dysregulated …
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Third Trimester Plasma Metabolites Associated with Gestational Diabetes: An Ancillary Analysis of the Healthy Beginnings Trial
… assays for primary metabolomics, aminomics, and lipidomics. Plasma metabolite comparisons were made between participants who developed GDM (n=27) and individuals without GDM (n=23) through UPLC-MS analysis with metabolomic assays for primary metabolomics, aminomics, and lipidomics. Dietary intake …
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Protection from HCV infection – Identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users.
… resistance. I used urinary metabolomics, serum lipidomics and the study of adaptive and innate immune responses. Each of these methods has demonstrated clear differences between EU cases and healthy controls and/or spontaneous resolvers of HCV infection. Urinary metabolomics suggest a potential …
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Roles of Phospholipase A/Acyltransferase Enzymes in Membrane Remodelling and Organelle Degradation
… yeast genetics, mammalian cell models, and lipidomics. In wild-type (wt) yeast, human PLAAT4 activity increased the size of lipid droplets, suggestive of fatty acid accumulation. The activity of PLAAT4 also resulted in ER morphological defects and growth inhibition. In a yeast mutant unable …
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APPLICATION OF OMICS APPROACHES IN DRUG DISCOVERY AND BIOMARKER IDENTIFICATION
… many fields of biological research. Among these, lipidomics and metabolomics are gaining increasing interest due to their close connection with the organism’s phenotype. As the main analytical goal of omics approaches is to identify and quantify as many compounds as possible within a studied …
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The biogeochemistry of lipid derived infochemical signals in the ocean
… microcosm amendment experiments, environmental lipidomics, and culture based studies. Oxylipins are a bioactive class of secondary metabolites produced by diatoms and other eukaryotic phytoplankton. Previous research has focused mainly on one class of oxylipins, polyunsaturated aldehydes (PUAs), …
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The remineralization of marine organic matter by diverse biological and abiotic processes
… geochemical analyses, and a new, high-throughput lipidomics method for identification of lipid biomarkers. I first assess the relative importance of particleattached microbial respiration compared to other processes that can degrade sinking marine particles. A hybrid methodological approach — …
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The remineralization of marine organic matter by diverse biological and abiotic processes
… geochemical analyses, and a new, high-throughput lipidomics method for identification of lipid biomarkers. I first assess the relative importance of particle-attached microbial respiration compared to other processes that can degrade sinking marine particles. A hybrid methodological approach - …
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The biogeochemistry of lipid derived infochemical signals in the ocean
… microcosm amendment experiments, environmental lipidomics, and culture based studies. Oxylipins are a bioactive class of secondary metabolites produced by diatoms and other eukaryotic phytoplankton. Previous research has focused mainly on one class of oxylipins, polyunsaturated aldehydes (PUAs), …
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BIOCHEMICAL CHARACTERIZATION OF ETHANOL MODIFIED PHOSPHOLIPIDS IN SACCHAROMYCES CEREVISIAE
… ROLE IN MEMBRANE DYNAMICS DURING FERMENTATION. LIPIDOMICS STRATEGIES, DRIVEN BY MODERN MASS SPECTROMETRY TECHNIQUES, ARE ABLE TO PROVIDE POWERFUL SENSITIVITY AND SELECTIVITY TO CHARACTERIZE SUCH A PHYSIOLOGICALLY RARE PHOSPHOLIPID.
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
… tissue inflammation and higher lethality. Lipidomics profiling of the purified sNS1 from wild-type and TS-virus revealed that they carried different lipid classes. Interestingly, treatment of human PBMCs with purified sNS1 from TS-virus resulted in higher pro-inflammatory cytokines …
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