Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Lipid uptake"”.
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… role in cancer, we identified a deregulation of lipid-related enzymes. Given that metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS …
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Design and Evaluation of Nanoparticle Systems for Bacterial Targeting
… using super-resolution microscopy. cFLs, lipid-based NPs engineered to fuse with cellular membranes, have been previously studied for their ability to deliver antimicrobial agents across the permeability barrier of the bacterial outer membrane (OM). In contrast, MOFs are solid NPs …
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Using chemical biology as a tool to probe the mechanism of the HDL receptor
… and metabolism by mediating cellular selective uptake of lipids from HDL. The mechanism underlying SR-BI-mediated lipid transfer involves a two-step process (binding followed by lipid transport) that is poorly understood. Our previous structure/activity analysis of the small-molecule inhibitor, …
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The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue
… to greater extent by insulin and glucose uptake in brown adipose tissue (BAT) was increased. The improved anti-lipolytic action may be attributed to increased vascularization in the epididymal white adipose tissue (eWAT), while increased glucose uptake in BAT was associated with increased …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… phagocytic resident macrophages, and subsequent lipid uptake and accumulation causing plaque growth and atheroma formation. Hyperlipidemia and other risk factors for cardiovascular disease promote the conversion of LDL to ox-LDL, which causes insult to the vascular wall. One of the earliest …
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The role of lipid laden macrophages in airways disease
… associated with Gastro-Oesophageal Reflux (GOR). Lipid laden macrophages (LLM) in the airway have previously been reported indicative of aspiration secondary to GOR. We hypothesised that lipid droplets from undigested or partially digested food may be aspirated into the airway and accumulate in …
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Role of long non-coding RNA in atherosclerosis
… of PELATON significantly reduced phagocytosis, lipid uptake and reactive oxygen species production in high- content analysis, with a significant reduction in phagocytosis independently validated. Furthermore, CD36, a key mediator of phagocytic oxLDL (oxidized low-density lipoprotein) uptake was …
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Lipoprotein Lipase in the Arterial Wall: Regulation by Dietary Fatty Acids
… deposition, total and selective LDL-cholesterol uptakes, and arterial lipoprotein lipase (LpL). Because consumption of n-3 fatty acids (FA), such as EPA and DHA, potentially reduces the risk for cardiovascular disease (CVD), we investigated the mechanisms whereby dietary FA, metabolic syndrome …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… of genes involved in mitochondrial function, lipid uptake and lipid storage. The dynamic and modifiable regulation of transcriptional pathways that control mitochondrial function and adipogenesis, as well as additional aspects of mammalian metabolism, will provide new approaches for …
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Biological role of conceptus derived factors during early pregnancy in ruminants
… (4) PPARG regulated pathways are involved in lipid uptake and metabolism in the day 14 conceptus; (5) Regulation of intracellular cortisol levels by HSD11B1 is important for conceptus development; (6) inactivation of bioactive cortisol by the enzyme HSD11B2 is not essential for conceptus …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
… fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. Unlike the blood vasculature, the lymphatic system does not have a …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
<p>Lipids, along with nucleic acids, carbohydrates, and proteins, are essential biomolecules.These diverse hydrophobic metabolites are composed of fatty acids and include sterols, phospholipids, and glycerides. Lipids can be broken down to fuel energy demands, form the structural basis of all …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… pro-oxidant, pro-inflammatory mediators and lipids such as cholesterol and fatty acids, which sustain proliferation, survival, and angiogenesis. Cholesterol can also be converted into oxysterols, endogenous LXR ligands that generally exert antiproliferative effects. However, …
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A Multiplexed, Multi-scale Optical Imaging Platform to Quantify Tumor Metabolic Heterogeneity
… of Bodipy FL C16 and TMRE to report on lipid uptake and mitochondrial activity, two potentially interrelated axes of metabolism. To validate this method, three sets of experiments were performed to establish that the two probes do not exhibit chemical, optical, or biological crosstalk. …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… greater adhesion of circulating monocytes and lipids. Endothelial senescence often occurs coincident with an inflammatory response within the endothelium. Recapitulating this mechanism of inducing EC senescence in vitro will facilitate a more precise understanding of how aging contributes to …
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Muscle disorder or metabolic disorder: genomic, transcriptomic, and metabolomic insights into the pathogenesis of wooden breast and white striping in commercial broiler chickens
… purports that evident dysfunction of glucose and lipid metabolism in wooden breast closely aligns with similar changes associated with type 2 diabetes and metabolic syndrome in mammals, and that reliance on insulin-independent glucose transport in the skeletal muscle of chickens may produce the …