Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Lipid transport"”.
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The Role of Mammalian Lipid Transport Protein ORP1 During Coxiella Burnetii Infection
… suggesting that C. burnetii regulation of lipid transport is critical for infection. The mammalian lipid transport protein ORP1L localizes to the CCV membrane and mediates CCV-ER membrane contact sites. ORP1L functions in lipid transport, including cholesterol efflux from late …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
… fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. Unlike the blood vasculature, the lymphatic system does not have a …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
… research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) characterised to have multidrug …
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Effects of Omega-3s and Vitamin E Prophylactic Diets and the Implications of Lipid Transport in Spinal Cord Injury
… hydrophobic molecules and how they are being transported after CNS trauma. The present study investigates the impact pre-treatment with ω3PUFAs and Vitamin E (alpha-tocopherol) in key functional outcomes observed during the acute phase of SCI. Additionally, we explored potential mechanisms …
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On the mechanisms of substrate translocation by the ABC transporter MsbA
… but also mediates the flopping of phospholipids and Lipid-A core across the plasma membrane. The MsbA protein has a similar fold as the mammalian multidrug resistance P-glycoproteins (P-gp, ABCB1) and might share functional features and substrate transport mechanisms with ABCB1. …
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Lipoproteins and heat shock proteins as measures of reproductive physiology in the soft shell clam, Mya arenaria
… The distribution of 14c triolein, an injected lipid tracer, occurred rapidly and was unaffected by the early stages of the disease hematopoietic neoplasia. These results, in combination with other evidence, provide support for the hypothesis that plasma is the primary conduit for lipid …
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Using chemical biology as a tool to probe the mechanism of the HDL receptor
… by mediating cellular selective uptake of lipids from HDL. The mechanism underlying SR-BI-mediated lipid transfer involves a two-step process (binding followed by lipid transport) that is poorly understood. Our previous structure/activity analysis of the small-molecule inhibitor, BLT-1, …
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A kinetic investigation of boronic acid/diol interactions and pattern-based recognition of [alpha]-chiral carboxylates
… acids have found applications spanning from lipid transport to Hydrogen fuel cells. The majority of the work presented in this dissertation will be aimed at gaining a better understanding of the Boron-Nitrogen interactions in ortho-aminomethyl functionalized boronic acids. Chapter 2 will …
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Energetics and mechanisms of substrate transport by the MATE transporter PfMATE
… stays, and increased mortality. Multidrug transporters play a critical role in the multidrug resistance. These efflux pumps can use the energy derived from ATP hydrolysis and/or electrochemical ion gradients to actively remove structurally unrelated drugs, such as antimicrobials and …
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A synthetic lipid scramblase built from DNA
… DNA-built enzyme that facilitates rapid lipid mixing between the two leaflets of a lipid bilayer. It thereby mimics the function of yet another class of membrane proteins $--$ lipid scramblases. Characterising this DNA nanostructure with gel electrophoresis, dynamic light scattering, …
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Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging
… and inflammation in adipose tissue and promoted lipid transport and oxidation in white adipose tissue of old female mice. In summary, my doctoral research reveals that adipose-derived PTX3 plays an essential role in regulating LPS-stimulated inflammation and cellular senescence during aging, and …
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Identification and Characterization of APOBEC1 mRNA Editing Targets: A Transcriptomics Approach
… apoB isoform with distinct functions in lipid transport. Other physiological mRNA targets of APOBEC1 editing have remained largely unknown. This thesis presents the development of an RNA-Seq method for the identification of mRNA editing events on a transcriptome-wide scale and its …
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Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models
… hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we …
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Finite Element Analysis to Investigate Lipid Absorption in UHMWPE Under Mechanical Loading
… pathways. One involves the diffusion of lipid species from synovial fluid into the UHMWPE matrix. Lipids diffuse particularly into amorphous regions and, by inter- acting with them, alter the chemical and mechanical structure over time. The combination of cyclic mechanical stress and …
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ApoE Receptors in Alzheimer's and CNS Function
… apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have also been identified as risk modifiers for AD. Despite nearly two decades of research, the mechanisms by which lipid transport proteins cause central nervous system (CNS) disease are not …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting the importance of lipid homeostasis in AD. MicroRNA-33 regulates the expression of ABCA1 and apoE lipidation, although its …
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Mutants of Drosophila Melanogaster's ABC Transporter, White, Have Altered Cholesterol-Mediated Acquisition of Memory that is Moderated with 5-HT
… an ATP binding cassette G-subfamily (ABCG) half transporter for the precursors of eye pigments and possibly biogenic amines, 5-hydroxytryptamine (5-HT) and dopamine that are critical for olfactory learning and memory in Drosophila. ABCG transporters are also known for their roles in lipid …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… (apo) can impact triglyceride (TG) transport by modulating VLDL assembly and secretion. Here we explore the impact of apoA-IV on VLDL particle expansion. Previous studies demonstrated that apoA-IV expression promotes apoB lipoprotein-mediated TG secretion in transfected enterocytes …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… of its target substrate GM1. GM1, a glycosphingolipid found primarily in the PM of neurons, is known to modulate Ca2+ flux through its interactions with Ca2+ channels and Ca2+ binding proteins. GM1 is also known to promote neuritogenesis through the activation of phosphorylated TRKs, receptors …
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Biomolecular transport at and through two-dimensional materials
… of nanopores for sequencing is the stochastic transport of DNA through the nanopore contributing to noise in the readout. Experiments have tested DNA transport though graphene nanopores however the strong hydrophobic interactions between DNA and graphene limit DNA capture and transport. To …
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