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Showing 1 to 20 of 23 for “"Lipid transfer"”.

  1. Structural determinants of stability to proteolysis, processing and impact on allergenic potential of non-specific lipid transfer proteins

    Abdullah, Syed UmerUniversity of East Anglia2012

    Lipid transfer proteins (LTPs) are a class of low molecular weight hydrophobic conserved proteins comprising four intramolecular disulphide bonds making the structure very resistant to proteolysis and harsh food processing conditions. These proteins are identified as strong allergens sensitizing …

    east-anglia Repository record

  2. The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds

    Aldakhil, Taibah2024

    … properties, including nonspecific lipid transfer protein (nsLTP), necessitating further research. The current study aimed to characterize nonspecific lipid transfer protein 1 (nsLTP1) from caraway seed, determine its three-dimensional structure, and analyze protein-ligand complex …

    chapman Repository record

  3. A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism

    Soccio, Raymond E

    … sterol-regulated gene encoding a StAR-related lipid transfer (START) protein, and its close homologues, StarD5 and StarD6. StarD4 was identified using cDNA microarrays, as liver StarD4 expression decreased three-fold in mice fed a high cholesterol diet. StarD4 also sterol-regulated in cultured …

    rockefeller Repository record

  4. Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds

    Alshammari, Saud2023

    <p>Trachyspermum ammi, commonly known as ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the …

    chapman Repository record

  5. Structural Characterization and <em>in vitro</em> Antiproliferative Activity of Non-Specific Lipid Transfer Protein 1 (nsLTP1) from Fennel (<em>Foeniculum vulgare</em>) Seeds

    Megeressa, Mekdes2023

    <p>Non-specific lipid transfer proteins (nsLTPs) are cationic proteins involved in intracellular lipid shuttling, in growth and reproduction, as well as in defense against pathogenic microbes. Even though the primary and spatial structures of some nsLTPs from different plants indicate their similar …

    chapman Repository record

  6. THE OPTIMIZATION OF A TIME-RESOLVED, VESICLE-BASED FLUORESCENCE ASSAY FOR THE ACTIVITY OF THE LIPID KINASE PI4K-IIIBETA AND THE EFFECT OF LIPID TRANSFER PROTEINS ON ENZYME ACTIVITY

    Muniz Correa, Marcelo VictorBrock University2023

    … eukaryotic membranes rely on PI kinases and PI transfer proteins (PITPs). In yeast, the PITP Sec14p is known to exchange PI and phosphatidylcholine between lipid bilayers in vitro and proposed to present PI to be phosphorylated by the PI4-kinase Pik1 in a heterotypic ligand exchange fashion. …

    brock Repository record

  7. Factors Influencing the Formation and Distribution of Cholesterol Esters in Human Plasma

    Yen, Frances TheresaUniversity of Illinois at Urbana-Champaign2015

    … factors influencing the lecithin-cholesterol acyltransferase (LCAT) and lipid transfer protein (LTP) reactions in plasma. These two plasma proteins play important roles in determining the formation and distribution of cholesterol esters in plasma.

    uiuc Repository record

  8. The role of CASM in the endolysosomal damage response

    Cross, JakeUniversity of Cambridge2025

    … activated, and subsequently mediated the lipidation of ATG8 (e.g. LC3A) family proteins directly onto damaged lysosome membranes. Specifically, this damage-induced lipidation occurs via the central V-ATPase – ATG16L1 axis, and onto phosphatidylserine (PS), a highly specific hallmark of …

    cambridge Repository record

  9. Linking Architecture and Function of Endoplasmic Reticulum - Plasma Membrane Contact Sites

    Hoffmann, Patrick ChristopherUniversity of Cambridge2020

    … and thereby promote cellular functions such as lipid metabolism, signalling and organelle biogenesis. The formation of cortical endoplasmic reticulum (cER) - plasma membrane (PM) contacts in budding yeast cells is mediated by a set of six conserved proteins. By combining correlative light and …

    cambridge Repository record

  10. Protein-sphingolipid interactions and their role in immunity and disease

    Shamin, MariaUniversity of Cambridge2021

    Sphingolipids are a diverse class of lipids involved in fundamental cellular processes. In addition to their role in membrane architecture, sphingolipids can act as bioactive molecules, regulate membrane protein function and be presented to the immune system as lipid antigens by CD1 family …

    cambridge Repository record

  11. PROTEINi screens identify ORP9 as a novel regulator of KRAS-driven signalling

    Weatherdon, Laura JaneUniversity of Cambridge2023

    … potential interactors of HPX-119370. ORP9 is a lipid transfer protein, and interacts with VAPs in the ER to transfer newly synthesised lipids out of the ER and into target organelles, such as the Golgi and late endosomes. ORP9 lipid cargoes include phosphatidylserine and cholesterol, which can …

    cambridge Repository record

  12. THE IMPACT OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN ON INTRACELLULAR HEPATIC NEUTRAL LIPID DISTRIBUTION AND TRAFFICKING

    MacArthur, Philip ScottWake Forest University2013

    Microsomal triglyceride transfer protein (MTP) is a multifunctional protein necessary for conversion of apolipoprotein B into precursor lipoproteins and bulk triglyceride (TG) movement into the endoplasmic reticulum (ER) for precursor lipoprotein expansion. Invertebrate forms of MTP (e.g. …

    wfu Repository record

  13. Brain Lipid Homeostasis as a Primary Function of Sleep: Insights from Drosophila melanogaster

    Pyfrom, Elana, Simone2026

    … for glial support of neuronal health through lipid homeostasis as a primary function of sleep using adult Drosophila melanogaster as a model. In Chapter 1, I highlight the links between lipid metabolism and sleep by presenting previous studies in glia and in invertebrate model systems. I …

    penn Repository record

  14. Identification and characterization of host genes involved in regulating replication of brome mosaic virus

    Suseendran, ParkeswaranVirginia Tech2025

    … membranes for their replication and lipid composition of these membranes is crucial for viral replication. I show here that BMV replication protein 1a causes redistribution of host Lam5 (Lipid transfer protein Anchored at a Membrane contact site 5) and that Lam5 is necessary for BMV …

    vt Repository record

  15. The Ligand and Membrane-binding Behaviour of the Phosphatidylinositol Transfer Proteins (PITPa & PITPb)

    Baptist, MatildaBrock University2016

    Human Class I phosphatidylinositol transfer proteins (PITPs) exists in two forms: PITPα and PITPβ. PITPs are believed to be lipid transfer proteins based on their capacity to transfer either phosphatidylinositol (PI) or phosphatidylcholine (PC) between membrane compartments in vitro. In Drosophila, …

    brock Repository record

  16. Structural Basis for the Regulation of the Ceramide Transfer Protein

    Prashek, Jennifer M.University of Missouri -- Kansas City2017

    Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT) protein for conversion to sphingomyelin (SM). CERT is a multi-domain protein that contains an amino terminal pleckstrin homology …

    umkc Repository record

  17. Use of Bioinformatics to Investigate Abiotic Stress in Arabidopsis and to Design Primers for Pathogen Detection

    Mane, ShrinivasraoVirginia Tech2007

    … patterns in Col-0 and Anti-PLDα. ROP8, PLDδ and lipid transfer proteins were among the differentially expressed genes between the two genotypes. Different microarray analyses methods (TM4 and Expresso) were also compared on two different data sets. The results obtained from Expresso analysis were …

    vt Repository record

  18. Genotype by feeding regimen interactions in growth selected chickens

    O'Sullivan, Neil P.Virginia Tech1991

    … embryo:egg and yolk:albumen, and proficiency of lipid transfer also increased but the latter was not associated with higher hatchability. Selection for 56-day body weight resulted in a divergence between lines at 21 days of age of 404% for body weight, 279% for feed intake and 138% for feed …

    vt Repository record

  19. Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons

    Schröder, Leonie FranziskaUniversität Bielefeld

    … integrity (Lesage et al., 2016) and at lipid transfer at ER-lysosome contact sites (Kumar et al., 2018). However, the function of VPS13C in Parkinson’s disease-relevant human dopaminergic neurons has not yet been investigated. This thesis established a PD-relevant model using human …

    bielefeld Repository record

  20. The Middle Region is Required for Phosphorylation Regulation of Ceramide Transfer Protein

    Bye, Nicole ElizabethUniversity of Missouri--Kansas City (UMKC)2013

    … synthesis is mediated by the ceramide transfer protein (CERT) in a nonvesicular fashion. CERT is a cytosolic protein containing multiple domains and motifs. The START (steroidogenic acute regulatory protein-related lipid transfer) domain at the C-terminus has the ability to transfer …

    umkc Repository record

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