Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Lipid synthesis"”.
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Redox-regulation of starch and lipid synthesis in leaves
… pentose phosphate cycle, NADPH export and ATP synthesis in response to light. The aim of the present thesis was to investigate whether a similar mechanism is also regulating carbon storage in leaves. Previous studies have shown that the key-regulatory enzyme of starch synthesis, ADPglucose …
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Effects of individual fatty acids on cellular lipid synthesis, lipoprotein secretion, and receptor-mediated lipoprotein uptake in Hep-G2 cells
Restriction data tranferred 2014-07-01T11:14:52-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Bioaccumulation of Triclocarban, Triclosan, and Methyl-triclosan in a North Texas Wastewater Treatment Plant Receiving Stream and Effects of Triclosan on Algal Lipid Synthesis.
… have been shown to reduce fatty acid biosynthesis and total lipid content by inhibiting the trans-2 enoyl- ACP reductase. The lipid synthesis pathway effects of TCS on field samples of Cladophora spp. were also investigated in this study by using [2-14C]acetate radiolabeling procedures. …
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Toxicity, selectivity, uptake, distribution and site of action of EPTC in corn (Zea mays L.) as affected by a herbicide antidote
… correlated with their injury responses to EPTC. Lipid synthesis was inhibited by more than 50% in Chlorella cells when EPTC was used at 2 x 10⁻⁴ M concentration after 1 hr of incubation. Similar result was found in corn protoplasts which was inhibited by 23% after 2 hr of incubation with EPTC at …
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Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models
… hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we …
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Acetate Increases Brain Purine Metabolism And Glial Cell Culture Fatty Acid Content: Studies Investigating Glyceryl Triacetate's Therapeutic Mechanism Of Action
… pathways including carbohydrate, protein, and lipid metabolism. Acetate increases the in vivo and in vitro acetylation-state of histones and is associated with altered cytokine balance. However, the effect that acetate supplementation has on brain purine and lipid content remains unknown. Since …
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The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
… improving IS, and decreasing activation of the lipid synthesis pathway. Contrary to our original hypothesis, a diet moderately high in n3PUFAs failed to lower hepatic fat content and partially blunted the beneficial effects of exercise as a treatment strategy for NAFLD and systemic insulin …
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Characterization of Drosophila Scap: Analysis of Mutants and Evidence for a Retention Factor
… SREBP pathway is one of the major regulators of lipid homeostasis and it is highly conserved among metazoans. SREBP is a transcription factor whose precursor is an endoplasmic reticulum (ER) transmembrane protein. In order to be activated it must travel to the Golgi apparatus via interaction with …
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The Role of Angiotensin II in Skeletal Muscle Metabolism
… were investigated. Fatty acid oxidation and lipid synthesis was measured using [1-14C]-palmitate, glucose oxidation and glycogen synthesis were measured using 14C-glucose. In addition,mitochondrial oxidative capacity was measured using an XF 24 Flux Analyzer (Seahorse Bioscience) and reactive …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
<p>The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The …
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AKR1B8 IS A NOVEL MODULATOR OF CRYPTIC SELF-RENEWAL AND SUSCEPTIBILITY TO COLITIS AND ASSOCIATED CANCER
… cytotoxic carbonyls and mediating fatty acid/lipid synthesis, and induces drug resistance to cytostatic antitumor agents containing carbonyl groups such as daunorubicin, resulting in failure of treatment. AKR1B10 may also participate in cell differentiation and carcinogenesis by depleting the …
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Bioenergetics and metabolism of eukaryotic cell proliferation
… in the context of biomass accumulation is the synthesis of lipids. Insights from this work has led to the realization that net-reductive pathways such as lipid synthesis may be rate-limited by oxidative reactions. Lastly, we established the green algae Chlorella vulgaris as a model system to …
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… Various changes were also observed concerning lipid synthesis and glutamine oxidation in the EMT models. Attempts to reverse the EMT-associated metabolic reprogramming in Panc-1 cells via pharmacological means had minimal impact on the overall EMT status. Collectively, these findings suggest …
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Epigenetic toxicity of PFOA in HepG2 cells and its role in lipid metabolism
… animals observed in prior studies, essential lipid metabolism gene were also studied and of which the mRNA expression levels are also changed, especially those regarding beta-oxidation pathway and lipid synthesis. Global methylation level of HepG2 cells was found to be in overall inverse …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… exhibited changes in anaerobic metabolism and lipid synthesis, respectively, whereas autophagy resulted in up-regulation of cellular component disassembly. The result indicated multiple drivers of MT1-MMP expression in MCF-7 cells.
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… Since adiponectin has a role in hepatic lipid metabolism, we hypothesize that adiponectin deficiency leads to fatty liver during pregnancy, worsening insulin resistance and contributing to GDM development. We compared adiponectin KO (strain B6;129-Adipoqtm1Chan/J) mice to WT (C57/B6) …
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Screening the effects of indoles on the proliferation of yeast via changes in lipid carbon flux
… and Schizosaccharomyces pombe yeast models. Lipids are essential to provide key elements to sustain cell growth and proliferation. In this study, indole, 2-PI and compound 209 were screened in an oleaginous yeast model, Lipomyces starkeyi (L. starkeyi), to ascertain their effect on culture …
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Mechanism of action of a tumour derived lipid mobilising factor
… Fat loss in cachexia is mediated by a 43kDa Lipid Mobilising Factor (LMF) sharing homology with endogenous Zinc-α2-Glycoprotein (ZAG). LMF and ZAG induced significant lipolysis in isolated epidydimal adipose tissue. This is attenuated by co-incubation with 10μM of antagonist SR59230A and …
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Physiological studies with the experimental herbicide isouron
… L.) leaf cells. The processes examined were photosynthesis, protein, ribonucleic acid (RNA) and lipid synthesis. Relative incorporation of radiolabeled precursors was the parameter measured to assess herbicidal effects. Results indicate that isouron and its monomethylurea derivative possess …
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The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
… factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty acid (UFA) regulate SREBP1 expression and subsequent …
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